乳房外Paget病发病机制研究进展

doi:10.35541/cjd.20220588

Abstract

Abstract: 【Abstract】 Extramammary Paget′s disease （EMPD） usually occurs in the apocrine gland-bearing areas, in which Paget cells are scattered in the middle and lower epidermis, arranged singly or in clusters, and spread to all skin layers. The pathogenesis of EMPD is still unclear, and the origin of Paget cells remains controversial. This review discusses the pathogenesis of EMPD from 4 aspects, i.e., histogenesis, driver genes, signal transduction pathways and immune environment, and focuses on relevant research progress.

Key words: Paget disease, extramammary, Pathogenesis, Histogenesis, Driver genes, Signal transduction pathways, Immune environment

Ding Meilin, Li Hongyang, Zhang Wei, Zeng Xuesi. Pathogenesis of extramammary Paget′s disease[J]. Chinese Journal of Dermatology,2023,e20220588. doi:10.35541/cjd.20220588

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Pathogenesis of extramammary Paget′s disease

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