鲜红斑痣的治疗现状及展望

doi:10.35541/cjd.20240047

Abstract

Abstract: 【Abstract】 Port-wine stains （PWS） are congenital vascular malformations mainly occurring on the face and neck. Currently, pulsed dye laser （PDL） is the gold standard for the treatment of PWS, but its complete clearance rate is less than 20%. In recent years, 755 nm alexandrite laser, Nd:YAG laser, intense pulsed light and photodynamic therapy have been applied to the treatment of PWS, and there has been new insights into the histopathological characteristics and pathogenesis of PWS. This article analyzes the current treatment status and disease features of PWS, with a view to providing a theoretical basis and new ideas for the treatment of PWS.

Key words: Vascular malformations, Port-wine stain, Laser therapy, Photochemotherapy, Surgical procedures, operative, Pathogenesis

Jiang Xian, Liu Lian, Zhang Ting. Treatment of port-wine stains: current status and prospects[J]. Chinese Journal of Dermatology, 2024, 57(7): 590-594.doi:10.35541/cjd.20240047

References ［32］

［1］	Yu L, Qin K, Deng X, et al. Epidemiological study of capillary malformation among 7299 infants under 1 year of age in China［J］. J Eur Acad Dermatol Venereol, 2023,37（3）:627⁃632. doi: 10.1111/jdv.18767.
［2］	Geronemus RG, Ashinoff R. The medical necessity of evaluation and treatment of port⁃wine stains［J］. J Dermatol Surg Oncol, 1991,17（1）:76⁃79. doi: 10.1111/j.1524⁃4725.1991.tb01597.x.
［3］	Zhao Q, Liu L, Li X, et al. An unexpected finding: treatment history associated with the quality of life in chinese patients with port⁃wine stains［J］. Clin Cosmet Investig Dermatol, 2023,16:1969⁃1975. doi: 10.2147/CCID.S421296.
［4］	Liu L, Zhou L, Zhao Q, et al. Histological analysis of different types of port⁃wine stains to guide clinical decision making: a retrospective study［J］. Indian J Dermatol Venereol Leprol, 2023,89（2）:204⁃212. doi: 10.25259/IJDVL_730_2021.
［5］	Shi W, Wang J, Lin Y, et al. Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People's Republic of China［J］. Drug Des Devel Ther, 2014,8:2531⁃2538. doi: 10.2147/DDDT.S71710.
［6］	Snast I, Lapidoth M, Kaftory R, et al. Does interval time between pulsed dye laser treatments for port⁃wine stains influence outcome? A systematic review and meta⁃analysis［J］. Lasers Med Sci, 2021,36（9）:1909⁃1916. doi: 10.1007/s10103⁃021⁃03264⁃7.
［7］	Sodha P, Wang JV, Aboul⁃Fettouh N, et al. Largest comparative analysis: novel large spot size 595 nm, high⁃energy, pulsed dye laser reduces number of treatments for improvement of adult and pediatric port wine birthmarks［J］. Lasers Surg Med, 2023,55（8）:741⁃747. doi: 10.1002/lsm.23693.
［8］	Passeron T, Maza A, Fontas E, et al. Treatment of port wine stains with pulsed dye laser and topical timolol: a multicenter randomized controlled trial［J］. Br J Dermatol, 2014,170（6）:1350⁃1353. doi: 10.1111/bjd.12772.
［9］	Tremaine AM, Armstrong J, Huang YC, et al. Enhanced port⁃wine stain lightening achieved with combined treatment of selective photothermolysis and imiquimod［J］. J Am Acad Dermatol, 2012,66（4）:634⁃641. doi: 10.1016/j.jaad.2011.11.958.
［10］	Fallahi M, Hallaji Z, Tavakolpour S, et al. Evaluating the efficacy and safety of topical sirolimus 0.2% cream as adjuvant therapy with pulsed dye laser for the treatment of port wine stain: a randomized, double⁃blind, placebo⁃controlled trial［J］. J Cosmet Dermatol, 2021,20（8）:2498⁃2506. doi: 10.1111/jocd. 13867.
［11］	Griffin TD Jr, Foshee JP, Finney R, et al. Port wine stain treated with a combination of pulsed dye laser and topical rapamycin ointment［J］. Lasers Surg Med, 2016,48（2）:193⁃196. doi: 10. 1002/lsm.22436.
［12］	Artzi O, Mehrabi JN, Heyman L, et al. Treatment of port wine stain with Tixel⁃induced rapamycin delivery following pulsed dye laser application［J］. Dermatol Ther, 2020,33（1）:e13172. doi: 10.1111/dth.13172.
［13］	Grillo E, González⁃Muñoz P, Boixeda P, et al. Alexandrite laser for the treatment of resistant and hypertrophic port wine stains: a clinical, histological and histochemical study［J］. Actas Dermosifiliogr, 2016,107（7）:591⁃596. doi: 10.1016/j.ad.2016. 04.016.
［14］	van Drooge AM, Bosveld B, van der Veen JP, et al. Long⁃pulsed 1064 nm Nd:YAG laser improves hypertrophic port⁃wine stains［J］. J Eur Acad Dermatol Venereol, 2013,27（11）:1381⁃1386. doi: 10.1111/jdv.12021.
［15］	Perruchoud DL, Cazzaniga S, Heidemeyer K, et al. Treatment of sporadic port⁃wine stains: a retrospective review of 17 cases consecutively treated by pulsed sequential dual wavelength 595 and 1064 nm laser［J］. J Eur Acad Dermatol Venereol, 2017,31（3）:557⁃563. doi: 10.1111/jdv.13975.
［16］	Wang T, Chen D, Yang J, et al. Safety and efficacy of dual⁃wavelength laser （1064 + 595 nm） for treatment of non⁃treated port⁃wine stains［J］. J Eur Acad Dermatol Venereol, 2018,32（2）:260⁃264. doi: 10.1111/jdv.14490.
［17］	Bjerring P, Christiansen K, Troilius A. Intense pulsed light source for the treatment of dye laser resistant port⁃wine stains［J］. J Cosmet Laser Ther, 2003,5（1）:7⁃13.
［18］	Wang B, Wu Y, Zhu X, et al. Treatment of neck port⁃wine stain with intense pulsed light in Chinese population［J］. J Cosmet Laser Ther, 2013,15（2）:85⁃90. doi: 10.3109/14764172.2012. 748204.
［19］	Yu W, Cen Q, Chen Y, et al. Combination therapy of pulsed dye laser with intense pulsed light in port⁃wine stain treatment: a prospective side⁃by⁃side comparison［J］. Dermatol Surg, 2021,47（9）:1229⁃1232. doi: 10.1097/DSS.0000000000003114.
［20］	Jiang L, Gu Y, Li X, et al. Changes of skin perfusion after photodynamic therapy for port wine stain［J］. Chin Med J （Engl）, 1998,111（2）:136⁃138.
［21］	Zhao Y, Tu P, Zhou G, et al. Hemoporfin photodynamic therapy for port⁃wine stain: a randomized controlled trial［J］. PLoS One, 2016,11（5）:e0156219. doi: 10.1371/journal.pone.0156219.
［22］	Gao K, Huang Z, Yuan KH, et al. Side⁃by⁃side comparison of photodynamic therapy and pulsed⁃dye laser treatment of port⁃wine stain birthmarks［J］. Br J Dermatol, 2013,168（5）:1040⁃1046. doi: 10.1111/bjd.12130.
［23］	Han Y, Ying H, Zhang X, et al. Retrospective study of photodynamic therapy for pulsed dye laser⁃resistant port⁃wine stains［J］. J Dermatol, 2020,47（4）:348⁃355. doi: 10.1111/1346⁃8138.15238.
［24］	Evans AV, Robson A, Barlow RJ, et al. Treatment of port wine stains with photodynamic therapy, using pulsed dye laser as a light source, compared with pulsed dye laser alone: a pilot study［J］. Lasers Surg Med, 2005,36（4）:266⁃269. doi: 10.1002/lsm. 20151.
［25］	Klein A, Szeimies RM, Bäumler W, et al. Indocyanine green⁃augmented diode laser treatment of port⁃wine stains: clinical and histological evidence for a new treatment option from a randomized controlled trial［J］. Br J Dermatol, 2012,167（2）:333⁃342. doi: 10.1111/j.1365⁃2133.2012.10950.x.
［26］	Zhou J, Qi Z, Jin X. Surgical correction for patients with port⁃wine stains and facial asymmetry［J］. J Cosmet Dermatol, 2020,19（12）:3307⁃3314. doi: 10.1111/jocd.13415.
［27］	Colletti G, Negrello S, Rozell⁃Shannon L, et al. Surgery for port⁃wine stains: a systematic review［J］. J Pers Med, 2023,13（7）:1058. doi: 10.3390/jpm13071058.
［28］	Wang Q, Yong C, Wang M, et al. Individualized surgical management of refractory port⁃wine stains in the scalp and face: a single⁃center retrospective study and a discussion of surgical strategies［J］. Clin Cosmet Investig Dermatol, 2022,15:1527⁃1535. doi: 10.2147/CCID.S370491.
［29］	Liu L, Li X, Zhao Q, et al. Pathogenesis of port⁃wine stains: directions for future therapies［J］. Int J Mol Sci, 2022,23（20）:12139. doi: 10.3390/ijms232012139.
［30］	Guo X, Zhu X, Gao J, et al. PLGA nanoparticles with CD133 aptamers for targeted delivery and sustained release of propranolol to hemangioma［J］. Nanomedicine （Lond）, 2017,12（21）:2611⁃2624. doi: 10.2217/nnm⁃2017⁃0130.
［31］	Xing L, Chen B, Li D, et al. Nd:YAG laser⁃induced morphology change and photothermal conversion of gold nanorods with potential application in the treatment of port⁃wine stain［J］. Lasers Med Sci, 2017,32（3）:629⁃640. doi: 10.1007/s10103⁃017⁃2158⁃1.
［32］	Burns JM, Jia W, Nelson JS, et al. Photothermal treatment of port⁃wine stains using erythrocyte⁃derived particles doped with indocyanine green: a theoretical study［J］. J Biomed Opt, 2018,23（12）:1⁃10. doi: 10.1117/1.JBO.23.12.121616.

[1]	Liu Qingfeng, Liu Lian, Diao Ping, Li Xiaoxue, Zhang Ting, Chen Haotian, Liu Xu, Jiang Xian. Diagnosis and treatment of port-wine stains-associated syndromes [J]. Chinese Journal of Dermatology, 2024, 57(7): 656-660.
[2]	Chen Haotian, Liu Lian, Zhang Ting, Liu Qingfeng, Li Xiaoxue, Diao Ping, Jiang Xian. Port-wine stains: mechanisms underlying the development and progression [J]. Chinese Journal of Dermatology, 2024, 57(7): 661-664.
[3]	Diao Ping, Han Chenglong, Liu Lian, Zhou Hui, Li Erlong, Jiang Xian. Efficacy and influencing factors of hematoporphyrin monomethyl ether-mediated photodynamic therapy in the treatment of adult patients with port-wine stains: a retrospective study [J]. Chinese Journal of Dermatology, 2024, 57(7): 595-600.
[4]	Zhang Ting, Liu Lian, Chen Haotian, Wei Danfeng, Liu Xu, Diao Ping, Liu Qingfeng, Jiang Xian. Efficacy of 595-nm pulsed dye laser in the treatment of port‐wine stains in 155 infants and toddlers: a retrospective analysis [J]. Chinese Journal of Dermatology, 2024, 57(7): 610-615.
[5]	Zhang Sheng, Wang Xiuwei, Chen Jianyou, Deng Wei, Zhang Haihua, Zhang Gaolei, Liu Xiaoyan, Su Wei. Efficacy of hematoporphyrin monomethyl ether-mediated photodynamic therapy in the treatment of facial port-wine stains in 15 children with Sturge-Weber syndrome [J]. Chinese Journal of Dermatology, 2024, 57(7): 616-622.
[6]	The Consensus Development Expert Group of Hematoporphyrin Monomethyl Ether-mediated Photodynamic Therapy for Treating Port-wine Stains. Expert consensus on hematoporphyrin monomethyl ether-mediated photodynamic therapy for treating port-wine stains （2024） [J]. Chinese Journal of Dermatology, 2024, 57(7): 581-589.
[7]	Feng Mengdi, Wang Wenqing. Regulatory roles of transcription factors and receptors in the pathogenesis of acne [J]. Chinese Journal of Dermatology, 2024, 57(6): 575-578.
[8]	Ge Xinhong, Ma Yingdong, Jiao Yaning, Liu Lingling, Zhou Mei, Zi Wei, Li Bowen. Analysis of efficacy and safety of 532-nm picosecond laser in the treatment of early-stage facial seborrheic keratosis [J]. Chinese Journal of Dermatology, 2024, 57(4): 359-362.
[9]	Ju Qiang, Li Jiaqi. Acne vulgaris revisited: from pathogenesis to treatment strategies [J]. Chinese Journal of Dermatology, 2024, 57(4): 289-294.
[10]	Yan Rufan, Liao Jieyue, Guo Ziyu, Yao Nan, Zhou Wenyu, Luo Shuaihantian, Zhang Guiying, Zhao Ming. Pathogenesis and targeted therapy of pemphigus [J]. Chinese Journal of Dermatology, 2024, 57(4): 374-378.
[11]	Zong Yangyongyi, Ma Chujun, Su Zhonglan. Eczematization following the treatment of psoriasis with biological agents: pathogenesis and management [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220578-e20220578.
[12]	Liu Tingwei, Meng Xiaoqi, Gu Duoduo, Pan Ruoxin, Zhang Yue, Xu Yang. Advances in the pathogenesis of rosacea [J]. Chinese Journal of Dermatology, 2024, 57(2): 186-190.
[13]	Zhang Qian, Zhang Jin′e, Guo Sen, Song Pu, Gao Lin, Li Chunying. Comparison of the efficacy of fractional CO2 laser combined with topical delivery of fluorouracil versus compound betamethasone injections in the treatment of vitiligo: a clinical observation [J]. Chinese Journal of Dermatology, 2024, 57(1): 34-38.
[14]	Zhong Jiemin, Shao Lei, Liang Yimin, Huang Qiongxiao, Xia Manqi, Liu Yumei. Comparative study on efficacy and safety of single microneedle radiofrequency versus photodynamic therapy in the treatment of inflammatory lesions of moderate to severe facial acne vulgaris [J]. Chinese Journal of Dermatology, 2023, 56(8): 751-755.
[15]	Song Zhiqiang, Chen Qiquan, Ge Lan. Insights into the progress in targeted therapy of atopic dermatitis from the perspective of its pathogenesis [J]. Chinese Journal of Dermatology, 2023, 56(8): 718-723.

Treatment of port-wine stains: current status and prospects

PDF

Knowledge

Abstract

Cite this article

share this article

References ［32］

Related Articles 15

Metrics

Comments

Recommended 10