Chinese Journal of Dermatology ›› 2024, Vol. 57 ›› Issue (6): 575-578.doi: 10.35541/cjd.20210457

• Reviews • Previous Articles    

Regulatory roles of transcription factors and receptors in the pathogenesis of acne

Feng Mengdi, Wang Wenqing   

  1. Department of Dermatology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2021-06-21 Revised:2021-11-02 Online:2024-06-15 Published:2024-06-03
  • Contact: Wang Wenqing

Abstract: 【Abstract】 The pathogenesis of acne is still unclear. At present, studies have confirmed roles of transcription factors and receptors in the occurrence and development of acne. Toll-like receptors, insulin-like growth factors, androgen receptors are risk factors for acne, while vitamin D receptors, retinoic acid receptors, epidermal growth factors, peroxisome proliferator-activator receptors are protective factors for acne, all of which are expected to be targets for prevention and treatment of acne. This review focuses on recent research progress in acne-related transcription factors and their receptors, in order to provide new directions for targeted therapy of acne.

Key words: Acne vulgaris, Transcription factors, Receptor of transcription factors, Pathogenesis, Signaling transduction pathway