Chinese Journal of Dermatology ›› 2024, e20220578.doi: 10.35541/cjd.20220578

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Eczematization following the treatment of psoriasis with biological agents: pathogenesis and management

Zong Yangyongyi, Ma Chujun, Su Zhonglan   

  1. Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2022-08-18 Revised:2023-08-30 Online:2024-01-29 Published:2024-03-01
  • Contact: Su Zhonglan E-mail:suzhonglan@jsph.org.cn
  • Supported by:
    National Natural Science Foundation of China(81773326)

Abstract: 【Abstract】 Eczematous dermatitis may occur in some patients with psoriasis following biological therapy. This review elucidates potential pathological mechanisms underlying this phenomenon and summarizes strategies for managing eczematization. Topical or systemic glucocorticoid treatment can effectively control some eczematous conditions; in some cases, discontinuation or switching to another types of biologic agents may be considered, especially the combination of immunosuppressants, dupilumab, or phosphodiesterase-4 inhibitors.

Key words: Psoriasis, Biological agents, Eczema, Dermatitis, atopic, Therapy, Pathogenesis