Chinese Journal of Dermatology ›› 2025, Vol. 58 ›› Issue (4): 369-373.doi: 10.35541/cjd.20240424
• Reviews • Previous Articles Next Articles
Xu Qiuyun, Ji Chao
Received:2024-08-09
Revised:2025-02-18
Online:2025-04-15
Published:2025-04-03
Contact:
Ji Chao
E-mail:jichaofy@fjmu.edu.cn
Supported by:Xu Qiuyun, Ji Chao. Pyoderma gangrenosum-related systemic complications[J]. Chinese Journal of Dermatology, 2025, 58(4): 369-373.doi:10.35541/cjd.20240424
| [1] | May MR, Rübben A, Lennertz A, et al. Dealing with corticosteroid and high⁃dose cyclosporine therapy in a pyoderma gangrenosum patient contracting a COVID⁃19 infection[J]. J Pers Med, 2022,12(2):173. doi: 10.3390/jpm12020173. |
| [2] | Maverakis E, Marzano AV, Le ST, et al. Pyoderma gangrenosum[J]. Nat Rev Dis Primers, 2020,6(1):81. doi: 10.1038/s41572⁃020⁃0213⁃x. |
| [3] | 胡清洁, 周敏, 姚煦. 坏疽性脓皮病36例临床特点分析及PARACELSUS评分与Delphi标准的比较[J]. 中华皮肤科杂志, 2023,56(5):410⁃414. doi: 10.35541/cjd.20220825. |
| [4] | Zhao H, Sengupta SK, Haddadin O, et al. Effects of comorbidities on delayed wound healing in patients with pyoderma gangrenosum[J]. J Eur Acad Dermatol Venereol, 2024. doi: 10.1111/jdv.20457. |
| [5] | Kridin K, Damiani G, Ludwig RJ, et al. Estimating the odds of ulcerative colitis⁃associated pyoderma gangrenosum: a population⁃based case⁃control study[J]. Dermatology, 2021,237(3):323⁃329. doi: 10.1159/000512931. |
| [6] | Kridin K, Damiani G, Ludwig RJ, et al. Quantification of the relationship between pyoderma gangrenosum and Crohn's disease: a population⁃based case⁃control study[J]. Scand J Gastroenterol, 2020,55(7):814⁃818. doi: 10.1080/00365521. 2020.1786849. |
| [7] | Ben Abdallah H, Fogh K, Vestergaard C, et al. Pyoderma gangrenosum and interleukin inhibitors: a semi⁃systematic review[J]. Dermatology, 2022,238(4):785⁃792. doi: 10.1159/00051 9320. |
| [8] | Antonelli E, Bassotti G, Tramontana M, et al. Dermatological manifestations in inflammatory bowel diseases[J]. J Clin Med, 2021,10(2):364. doi: 10.3390/jcm10020364. |
| [9] | Argüelles⁃Arias F, Castro⁃Laria L, Lobatón T, et al. Characteristics and treatment of pyoderma gangrenosum in inflammatory bowel disease[J]. Dig Dis Sci, 2013,58(10):2949⁃2954. doi: 10.1007/s10620⁃013⁃2762⁃2. |
| [10] | van Loo G, Bertrand M. Death by TNF: a road to inflammation[J]. Nat Rev Immunol, 2023,23(5):289⁃303. doi: 10.1038/s41577⁃022⁃00792⁃3. |
| [11] | Holmes Z, Nguyen J, Courtney A, et al. Treatment of severe, refractory pyoderma gangrenosum with infliximab, adalimumab and intravenous immunoglobulin[J]. Australas J Dermatol, 2023,64(3):433⁃435. doi: 10.1111/ajd.14067. |
| [12] | Verstockt B, Salas A, Sands BE, et al. IL⁃12 and IL⁃23 pathway inhibition in inflammatory bowel disease[J]. Nat Rev Gastroenterol Hepatol, 2023,20(7):433⁃446. doi: 10.1038/s41575⁃023⁃00768⁃1. |
| [13] | Fanizza J, D'Amico F, Lusetti F, et al. The role of IL⁃23 inhibitors in Crohn's disease[J]. J Clin Med, 2023,13(1):224. doi: 10.3390/jcm13010224. |
| [14] | Westerdahl JS, Nusbaum KB, Chung CG, et al. Ustekinumab as adjuvant treatment for all pyoderma gangrenosum subtypes[J]. J Dermatolog Treat, 2022,33(4):2386⁃2390. doi: 10.1080/0954 6634.2021.1937475. |
| [15] | Burgdorf B, Schlott S, Ivanov IH, et al. Successful treatment of a refractory pyoderma gangrenosum with risankizumab[J]. Int Wound J, 2020,17(4):1086⁃1088. doi: 10.1111/iwj.13359. |
| [16] | Reese AM, Erickson K, Reed KB, et al. Modified dose of guselkumab for treatment of pyoderma gangrenosum[J]. JAAD Case Rep, 2022,21:38⁃42. doi: 10.1016/j.jdcr.2021.11.030. |
| [17] | Chen Y, Ye X, Escames G, et al. The NLRP3 inflammasome: contributions to inflammation⁃related diseases[J]. Cell Mol Biol Lett, 2023,28(1):51. doi: 10.1186/s11658⁃023⁃00462⁃9. |
| [18] | Jatana S, Ponti AK, Johnson EE, et al. A novel murine model of pyoderma gangrenosum reveals that inflammatory skin⁃gut crosstalk is mediated by IL⁃1β⁃primed neutrophils[J]. Front Immunol, 2023,14:1148893. doi: 10.3389/fimmu.2023.1148893. |
| [19] | O'Connor C, Gallagher C, Hollywood A, et al. Anakinra for recalcitrant pyoderma gangrenosum[J]. Clin Exp Dermatol, 2021,46(8):1558⁃1560. doi: 10.1111/ced.14809. |
| [20] | Ben Abdallah H, Fogh K, Vestergaard C, et al. Pyoderma gangrenosum and interleukin inhibitors: a semi⁃systematic review[J]. Dermatology, 2022,238(4):785⁃792. doi: 10.1159/00051 9320. |
| [21] | McPhie ML, Kirchhof MG. Pyoderma gangrenosum treated with secukinumab: a case report[J]. SAGE Open Med Case Rep, 2020,8:2050313X20940430. doi: 10.1177/2050313X20940430. |
| [22] | Tee MW, Avarbock AB, Ungar J, et al. Rapid resolution of pyoderma gangrenosum with brodalumab therapy[J]. JAAD Case Rep, 2020,6(11):1167⁃1169. doi: 10.1016/j.jdcr.2020.08.033. |
| [23] | Kao AS, King AD, Daveluy S. Successful treatment of cabozantinib⁃induced pyoderma gangrenosum with ixekizumab therapy: a case report[J]. Dermatol Ther, 2022,35(9):e15716. doi: 10.1111/dth.15716. |
| [24] | Dissemond J, Marzano AV, Hampton PJ, et al. Pyoderma gangrenosum: treatment options[J]. Drugs, 2023,83(14):1255⁃1267. doi: 10.1007/s40265⁃023⁃01931⁃3. |
| [25] | Deng Z, Wang S, Wu C, et al. IL⁃17 inhibitor⁃associated inflammatory bowel disease: a study based on literature and database analysis[J]. Front Pharmacol, 2023,14:1124628. doi: 10.3389/fphar.2023.1124628. |
| [26] | Salas A, Hernandez⁃Rocha C, Duijvestein M, et al. JAK⁃STAT pathway targeting for the treatment of inflammatory bowel disease[J]. Nat Rev Gastroenterol Hepatol, 2020,17(6):323⁃337. doi: 10.1038/s41575⁃020⁃0273⁃0. |
| [27] | Herrera⁃deGuise C, Serra⁃Ruiz X, Lastiri E, et al. JAK inhibitors: a new dawn for oral therapies in inflammatory bowel diseases[J]. Front Med (Lausanne), 2023,10:1089099. doi: 10. 3389/fmed.2023.1089099. |
| [28] | Castro L. JAK inhibitors: a novel, safe, and efficacious therapy for pyoderma gangrenosum[J]. Int J Dermatol, 2023,62(8):1088⁃1093. doi: 10.1111/ijd.16676. |
| [29] | Kridin K, Ankary⁃Khaner M, Kridin M, et al. Hematological malignancy⁃associated pyoderma gangrenosum: evaluating the magnitude of the association[J]. Front Med (Lausanne), 2024,11:1425454. doi: 10.3389/fmed.2024.1425454. |
| [30] | Ruocco E, Sangiuliano S, Gravina AG, et al. Pyoderma gangrenosum: an updated review[J]. J Eur Acad Dermatol Venereol, 2009,23(9):1008⁃1017. doi: 10.1111/j.1468⁃3083. 2009.03199.x. |
| [31] | Montagnon CM, Fracica EA, Patel AA, et al. Pyoderma gangrenosum in hematologic malignancies: a systematic review[J]. J Am Acad Dermatol, 2020,82(6):1346⁃1359. doi: 10.1016/j.jaad.2019.09.032. |
| [32] | Martins M, Barbosa J, Eusébio SP, et al. From the deep: overlap of neutrophilic dermatoses disorders associated with acute myeloid leukemia[J]. Cureus, 2023,15(1):e33456. doi: 10.7759/cureus.33456. |
| [33] | Szalat R, Monsel G, Le Goff W, et al. The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: association with IgA isotype and inflammatory profile[J]. J Am Acad Dermatol, 2015,73(5):809⁃820. doi: 10.1016/j.jaad.2015. 07.031. |
| [34] | Maglie R, Genovese G, Solimani F, et al. Immune⁃mediated dermatoses in patients with haematological malignancies: a comprehensive review[J]. Am J Clin Dermatol, 2020,21(6):833⁃854. doi: 10.1007/s40257⁃020⁃00553⁃9. |
| [35] | Parrondo RD, Iqbal M, Von Roemeling R, et al. IRAK⁃4 inhibition: emavusertib for the treatment of lymphoid and myeloid malignancies[J]. Front Immunol, 2023,14:1239082. doi: 10.3389/fimmu.2023.1239082. |
| [36] | Ferrarini I, Rigo A, Zamò A, et al. Classical Hodgkin lymphoma cells may promote an IL⁃17⁃enriched microenvironment[J]. Leuk Lymphoma, 2019,60(14):3395⁃3405. doi: 10.1080/1042 8194.2019.1636983. |
| [37] | Wang F, Li Y, Yang Z, et al. Targeting IL⁃17A enhances imatinib efficacy in Philadelphia chromosome⁃positive B⁃cell acute lymphoblastic leukemia[J]. Nat Commun, 2024,15(1):203. doi: 10.1038/s41467⁃023⁃44270⁃3. |
| [38] | Yu S, Jiang J. Immune infiltration⁃related genes regulate the progression of AML by invading the bone marrow microenvironment[J]. Front Immunol, 2024,15:1409945. doi: 10.3389/fimmu.2024.1409945. |
| [39] | Blicharz L, Czuwara J, Rudnicka L, et al. Autoinflammatory keratinization diseases⁃the concept, pathophysiology, and clinical implications[J]. Clin Rev Allergy Immunol, 2023,65(3):377⁃402. doi: 10.1007/s12016⁃023⁃08971⁃3. |
| [40] | Wouters F, Bogie J, Wullaert A, et al. Recent insights in pyrin inflammasome activation: identifying potential novel therapeutic approaches in pyrin⁃associated autoinflammatory syndromes[J]. J Clin Immunol, 2023,44(1):8. doi: 10.1007/s10875⁃023⁃01621⁃5. |
| [41] | D'Onghia M, Malvaso D, Galluccio G, et al. Evidence on hidradenitis suppurativa as an autoinflammatory skin disease[J]. J Clin Med, 2024,13(17):5211. doi: 10.3390/jcm13175211. |
| [42] | Yamanaka K. New treatment of pyoderma gangrenosum and hidradenitis suppurativa: a review[J]. J Dermatol, 2024,51(2):172⁃179. doi: 10.1111/1346⁃8138.17031. |
| [43] | Brandão L, Moura RR, Marzano AV, et al. Variant enrichment analysis to explore pathways functionality in complex autoinflammatory skin disorders through whole exome sequencing analysis[J]. Int J Mol Sci, 2022,23(4):2278. doi: 10.3390/ijms23042278. |
| [44] | Cugno M, Borghi A, Marzano AV. PAPA, PASH and PAPASH syndromes: pathophysiology, presentation and treatment[J]. Am J Clin Dermatol, 2017,18(4):555⁃562. doi: 10.1007/s40257⁃017⁃0265⁃1. |
| [45] | Chokoeva AA, Cardoso JC, Wollina U, et al. Pyoderma gangrenosum⁃a novel approach?[J]. Wien Med Wochenschr, 2017,167(3⁃4):58⁃65. doi: 10.1007/s10354⁃016⁃0472⁃z. |
| [46] | Xu A, Strunk A, Garg A, et al. Prevalence of inflammatory bowel disease in patients with pyoderma gangrenosum: a population⁃based analysis[J]. J Am Acad Dermatol, 2022,86(6):1351⁃1352. doi: 10.1016/j.jaad.2021.05.006. |
| [47] | Binus AM, Qureshi AA, Li VW, et al. Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients[J]. Br J Dermatol, 2011,165(6):1244⁃1250. doi: 10.1111/j.1365⁃2133.2011.10565.x. |
| [48] | Kridin K, Cohen AD, Amber KT. Underlying systemic diseases in pyoderma gangrenosum: a systematic review and meta⁃analysis[J]. Am J Clin Dermatol, 2018,19(4):479⁃487. doi: 10.1007/s40257⁃018⁃0356⁃7. |
| [49] | Kridin K, Damiani G, Cohen AD. Rheumatoid arthritis and pyoderma gangrenosum: a population⁃based case⁃control study[J]. Clin Rheumatol, 2021,40(2):521⁃528. doi: 10.1007/s10067⁃020⁃05253⁃7. |
| [50] | Cugno M, Gualtierotti R, Meroni PL, et al. Inflammatory joint disorders and neutrophilic dermatoses: a comprehensive review[J]. Clin Rev Allergy Immunol, 2018,54(2):269⁃281. doi: 10. 1007/s12016⁃017⁃8629⁃0. |
| [51] | Weber B, Liao KP. Evidence for biologic drug modifying anti⁃rheumatoid drugs and association with cardiovascular disease risk mitigation in inflammatory arthritis[J]. Rheum Dis Clin North Am, 2023,49(1):165⁃178. doi: 10.1016/j.rdc.2022.08.005. |
| [52] | Maalouf D, Battistella M, Bouaziz JD. Neutrophilic dermatosis: disease mechanism and treatment[J]. Curr Opin Hematol, 2015,22(1):23⁃29. doi: 10.1097/MOH.0000000000000100. |
| [53] | Sawka E, Zhou A, Latour E, et al. Inflammatory arthritis⁃associated pyoderma gangrenosum: a systematic review[J]. Clin Rheumatol, 2021,40(10):3963⁃3969. doi: 10.1007/s10067⁃021⁃05768⁃7. |
| [54] | Xing F, Chiu KH, Yang J, et al. Pyoderma gangrenosum with pulmonary involvement: a pulmonary special report and literature review[J]. Expert Rev Respir Med, 2022,16(2):149⁃159. doi: 10.1080/17476348.2022.2027756. |
| [55] | Shavit E, Dagan O, Cohen AD, et al. Risk of cardiovascular diseases in pyoderma gangrenosum: a population⁃based study[J]. J Eur Acad Dermatol Venereol, 2023,37(2):e197⁃e199. doi: 10.1111/jdv.18527. |
| [56] | Gillard M, Anuset D, Maillard H, et al. Comorbidities of pyoderma gangrenosum: a retrospective multicentric analysis of 126 patients[J]. Br J Dermatol, 2018,179(1):218⁃219. doi: 10. 1111/bjd.16463. |
| [57] | Zaino ML, Schadt CR, Callen JP, et al. Pyoderma gangrenosum: diagnostic criteria, subtypes, systemic associations, and workup[J]. Dermatol Clin, 2024,42(2):157⁃170. doi: 10.1016/j.det. 2023.08.003. |
| [58] | Kridin K, Solomon A, Britva RL, et al. Chronic renal comorbidities in pyoderma gangrenosum: a retrospective cohort study[J]. Immunol Res, 2021,69(3):249⁃254. doi: 10.1007/s12026⁃021⁃09187⁃3. |
| [59] | Al Ghazal P, Herberger K, Schaller J, et al. Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients[J]. Orphanet J Rare Dis, 2013,8:136. doi: 10.1186/1750⁃1172⁃8⁃136. |
| [60] | Shah M, Sachdeva M, Gefri A, et al. Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review[J]. Int J Dermatol, 2020,59(2):154⁃158. doi: 10.1111/ijd.14637. |
| [61] | Kridin K, Laufer Britva R, Tzur Bitan D, et al. Is pyoderma gangrenosum associated with solid malignancies? Insights from a population⁃based cohort study[J]. Australas J Dermatol, 2021,62(3):336⁃341. doi: 10.1111/ajd.13631. |
| [62] | Ravi M, Trinidad J, Spaccarelli N, et al. The impact of comorbidity identification on outcomes in patients with pyoderma gangrenosum: a retrospective cohort study of previously hospitalized patients[J]. J Am Acad Dermatol, 2022,87(1):194⁃197. doi: 10.1016/j.jaad.2021.07.032. |
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