Chinese Journal of Dermatology ›› 2025, e20220881.doi: 10.35541/cjd.20220881
• Reviews • Previous Articles Next Articles
Xu Zhuohong1, Hu Yu2, Gu Heng2
Received:
2022-12-08
Revised:
2024-07-01
Online:
2025-01-24
Published:
2025-01-23
Contact:
Gu Heng
E-mail:guheng@aliyun.com
Supported by:
Xu Zhuohong, Hu Yu, Gu Heng. Role of mesenchymal stem cell-derived exosomes in skin diseases[J]. Chinese Journal of Dermatology,2025,e20220881. doi:10.35541/cjd.20220881
[1] | Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells[J]. Science, 1999,284(5411):143⁃147. doi: 10.1126/science.284.5411.143. |
[2] | Xunian Z, Kalluri R. Biology and therapeutic potential of mesenchymal stem cell⁃derived exosomes[J]. Cancer Sci, 2020,111(9):3100⁃3110. doi: 10.1111/cas.14563. |
[3] | Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes[J]. Science, 2020,367(6478):eaau6977. doi: 10.1126/science.aau6977. |
[4] | Kusuma GD, Barabadi M, Tan JL, et al. To Protect and to preserve: novel preservation strategies for extracellular vesicles[J]. Front Pharmacol, 2018,9:1199. doi: 10.3389/fphar.2018. 01199. |
[5] | Chen J, Chen J, Cheng Y, et al. Mesenchymal stem cell⁃derived exosomes protect beta cells against hypoxia⁃induced apoptosis via miR⁃21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation[J]. Stem Cell Res Ther, 2020,11(1):97. doi: 10.1186/s13287⁃020⁃01610⁃0. |
[6] | Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: a novel stem cell⁃based therapy for cardiovascular disease[J]. Regen Med, 2011,6(4):481⁃492. doi: 10.2217/rme.11.35. |
[7] | Sipos F, Mzes G. Controversies in therapeutic application of mesenchymal stem cell⁃derived secretome[J]. BIOCELL, 2022, 46(4): 4.doi: 10.32604/biocell.2022.018200. |
[8] | Toh WS, Lai RC, Zhang B, et al. MSC exosome works through a protein⁃based mechanism of action[J]. Biochem Soc Trans, 2018,46(4):843⁃853. doi: 10.1042/BST20180079. |
[9] | Tang XD, Shi L, Monsel A, et al. Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang⁃1 mRNA[J]. Stem Cells, 2017,35(7):1849⁃1859. doi: 10.1002/stem.2619. |
[10] | Katsuda T, Ochiya T. Molecular signatures of mesenchymal stem cell⁃derived extracellular vesicle⁃mediated tissue repair[J]. Stem Cell Res Ther, 2015,6:212. doi: 10.1186/s13287⁃015⁃0214⁃y. |
[11] | Ge L, Xun C, Li W, et al. Extracellular vesicles derived from hypoxia⁃preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR⁃612[J]. J Nanobiotechnology, 2021,19(1):380. doi: 10.1186/s12951⁃021⁃01126⁃6. |
[12] | Tavasolian F, Hosseini AZ, Soudi S, et al. miRNA⁃146a improves immunomodulatory effects of MSC⁃derived exosomes in rheumatoid arthritis[J]. Curr Gene Ther, 2020,20(4):297⁃312. doi: 10.2174/1566523220666200916120708. |
[13] | Zhang Y, Pan Y, Liu Y, et al. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor⁃β receptor inhibition[J]. Stem Cell Res Ther, 2021,12(1):434. doi: 10.1186/s13287⁃021⁃02517⁃0. |
[14] | Gezer U, Özgür E, Cetinkaya M, et al. Long non⁃coding RNAs with low expression levels in cells are enriched in secreted exosomes[J]. Cell Biol Int, 2014,38(9):1076⁃1079. doi: 10. 1002/cbin.10301. |
[15] | Li B, Luan S, Chen J, et al. The MSC⁃derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via microRNA⁃152⁃3p[J]. Mol Ther Nucleic Acids, 2020,19:814⁃826. doi: 10.1016/j.omtn.2019.11.034. |
[16] | Dou R, Zhang X, Xu X, et al. Mesenchymal stem cell exosomal tsRNA⁃21109 alleviate systemic lupus erythematosus by inhibiting macrophage M1 polarization[J]. Mol Immunol, 2021,139:106⁃114. doi: 10.1016/j.molimm.2021.08.015. |
[17] | Lai RC, Tan SS, Teh BJ, et al. Proteolytic potential of the MSC exosome proteome: implications for an exosome⁃mediated delivery of therapeutic proteasome[J]. Int J Proteomics, 2012,2012:971907. doi: 10.1155/2012/971907. |
[18] | Zhang B, Wang M, Gong A, et al. HucMSC⁃exosome mediated⁃Wnt4 signaling is required for cutaneous wound healing[J]. Stem Cells, 2015,33(7):2158⁃2168. doi: 10.1002/stem.1771. |
[19] | Zhang B, Shi Y, Gong A, et al. HucMSC exosome⁃delivered 14⁃3⁃3ζ orchestrates self⁃control of the Wnt response via modulation of YAP during cutaneous regeneration[J]. Stem Cells, 2016,34(10):2485⁃2500. doi: 10.1002/stem.2432. |
[20] | Shabbir A, Cox A, Rodriguez⁃Menocal L, et al. Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro[J]. Stem Cells Dev, 2015,24(14):1635⁃1647. doi: 10.1089/scd. 2014.0316. |
[21] | Liu H, Liang Z, Wang F, et al. Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage⁃ dependent mechanism[J]. JCI Insight, 2019,4(24):e131273. doi: 10.1172/jci.insight.131273. |
[22] | Yang S, Liang X, Song J, et al. A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG⁃6[J]. Stem Cell Res Ther, 2021,12(1):315. doi: 10.1186/s13287⁃021⁃02404⁃8. |
[23] | Ha DH, Kim HK, Lee J, et al. Mesenchymal stem/stromal cell⁃derived exosomes for immunomodulatory therapeutics and skin regeneration[J]. Cells, 2020,9(5):1157. doi: 10.3390/cells9051157. |
[24] | Silachev DN, Goryunov KV, Shpilyuk MA, et al. Effect of MSCs and MSC⁃derived extracellular vesicles on human blood coagulation[J]. Cells, 2019,8(3):258. doi: 10.3390/cells803 0258. |
[25] | 夏娜, 高超, 刘璇, 等. 脐带间充质干细胞外泌体对急性皮肤创面愈合的初步研究[J].中华皮肤科杂志, 2022,55(5):382⁃388. doi: 10.35541/cjd.20210831. |
[26] | Zhao W, Zhang R, Zang C, et al. Exosome derived from mesenchymal stem cells alleviates pathological scars by inhibiting the proliferation, migration and protein expression of fibroblasts via delivering miR⁃138⁃5p to target SIRT1[J]. Int J Nanomedicine, 2022,17:4023⁃4038. doi: 10.2147/IJN.S377317. |
[27] | Yang C, Sun J, Tian Y, et al. Immunomodulatory effect of MSCs and MSCs⁃derived extracellular vesicles in systemic lupus erythematosus[J]. Front Immunol, 2021,12:714832. doi: 10. 3389/fimmu.2021.714832. |
[28] | Bolandi Z, Mokhberian N, Eftekhary M, et al. Adipose derived mesenchymal stem cell exosomes loaded with miR⁃10a promote the differentiation of Th17 and Treg from naive CD4(+) T cell[J]. Life Sci, 2020,259:118218. doi: 10.1016/j.lfs.2020.118218. |
[29] | Adamo A, Brandi J, Caligola S, et al. Extracellular vesicles mediate mesenchymal stromal cell⁃dependent regulation of B cell PI3K⁃AKT signaling pathway and actin cytoskeleton[J]. Front Immunol, 2019,10:446. doi: 10.3389/fimmu.2019.00446. |
[30] | Shahir M, Mahmoud Hashemi S, Asadirad A, et al. Effect of mesenchymal stem cell⁃derived exosomes on the induction of mouse tolerogenic dendritic cells[J]. J Cell Physiol, 2020,235(10):7043⁃7055. doi: 10.1002/jcp.29601. |
[31] | Dong B, Wang C, Zhang J, et al. Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid⁃resistant asthma by reshaping macrophage polarization[J]. Stem Cell Res Ther, 2021,12(1):204. doi: 10. 1186/s13287⁃021⁃02244⁃6. |
[32] | Ye Z, Liang Y, Lin B, et al. Gingiva⁃derived mesenchymal stem cells attenuate imiquimod⁃ (IMQ⁃) induced murine psoriasis⁃like skin inflammation[J]. Stem Cells Int, 2022,2022:6544514. doi: 10.1155/2022/6544514. |
[33] | 韩齐心, 牛旭平, 刘佳, 等. 间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展[J].中华皮肤科杂志, 2020,53(2):151⁃154. doi: 10.35541/cjd.20190012. |
[34] | Ghoreschi K, Balato A, Enerbäck C, et al. Therapeutics targeting the IL⁃23 and IL⁃17 pathway in psoriasis[J]. Lancet, 2021,397(10275):754⁃766. doi: 10.1016/S0140⁃6736(21)00184⁃7. |
[35] | Xu F, Fei Z, Dai H, et al. Mesenchymal stem cell⁃derived extracellular vesicles with high PD⁃L1 Expression for Autoimmune Diseases Treatment[J]. Adv Mater, 2022,34(1):e2106265. doi: 10.1002/adma.202106265. |
[36] | Shin KO, Ha DH, Kim JO, et al. Exosomes from human adipose tissue⁃derived mesenchymal stem cells promote epidermal barrier repair by inducing de novo synthesis of ceramides in atopic dermatitis[J]. Cells, 2020,9(3):680. doi: 10.3390/cells 9030680. |
[37] | Deng M, Yu TZ, Li D, et al. Human umbilical cord mesenchymal stem cell⁃derived and dermal fibroblast⁃derived extracellular vesicles protect dermal fibroblasts from ultraviolet radiation⁃induced photoaging in vitro[J]. Photochem Photobiol Sci, 2020,19(3):406⁃414. doi: 10.1039/c9pp00421a. |
[38] | Zhang K, Yu L, Li FR, et al. Topical application of exosomes derived from human umbilical cord mesenchymal stem cells in combination with sponge spicules for treatment of photoaging[J]. Int J Nanomedicine, 2020,15:2859⁃2872. doi: 10.2147/IJN.S249751. |
[39] | Ding Q, Sun R, Wang P, et al. Protective effects of human induced pluripotent stem cell⁃derived exosomes on high glucose⁃induced injury in human endothelial cells[J]. Exp Ther Med, 2018,15(6):4791⁃4797. doi: 10.3892/etm.2018.6059. |
[1] | Xu Zhongyi, Xing Xiaoxue, Dong Yaqi, Zhang Chengfeng, Xiang Leihong. Retrospective analysis of clinical manifestations and treatment outcomes in 254 patients with melasma in a tertiary grade-A hospital in Shanghai [J]. Chinese Journal of Dermatology, 2025, 58(9): 808-815. |
[2] | Jiang Ziqi, Zhong Judan, Chen Tingqiao, Chen Jin. Pathogenesis and treatment of melasma [J]. Chinese Journal of Dermatology, 2025, 58(9): 868-872. |
[3] | Zhong Jiemin, Li Wei, Zhang Shujuan, Yang Yan, Xue Rujun, Li Xinyi, Ke Yanan, Chen Xiaoyin, Chen Quan. Comparison of the efficacy and safety of nanomicroneedle- versus ultrasound-mediated delivery of tranexamic acid for the treatment of melasma: a randomized controlled study [J]. Chinese Journal of Dermatology, 2025, 58(9): 829-833. |
[4] | Guliziba·Tuersun, Zhao Yanan, Wang Hongjuan, Kang Xiaojing, Qu Yuanyuan. Efficacy of autologous melanocyte transplantation combined with 308-nm light-emitting diode phototherapy at escalating doses in the treatment of refractory stable vitiligo: a clinical observation [J]. Chinese Journal of Dermatology, 2025, 58(9): 852-856. |
[5] | Dai Yeqin, Song Xiuzu. Application of hair follicle transplantation and follicular cell suspension transplantation in the treatment of vitiligo [J]. Chinese Journal of Dermatology, 2025, 58(9): 882-885. |
[6] | Zhou Miaoni, Sheng Anqi, Fu Lifang, Jin Rong, Xu Wen, Wei Xiaodong, Xu Ai′e . Efficacy and safety of an antioxidant gel containing tea polyphenols combined with narrow-band ultraviolet B in the treatment of vitiligo: a single-center randomized controlled trial [J]. Chinese Journal of Dermatology, 2025, 58(9): 834-838. |
[7] | Zhan Jinshan, Xuan Xiuyun, Cao Juanmei, Chen Fangqi, Huang Changzheng. Progress in treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis [J]. Chinese Journal of Dermatology, 2025, 58(8): 785-788. |
[8] | Luo Shuaihantian, Long Hai, Lu Qianjin. Research advances in systemic lupus erythematosus in 2024 [J]. Chinese Journal of Dermatology, 2025, 58(8): 777-780. |
[9] | Bai Qi, Zhu Mingfang, Wu Qingting, Ji Xiaotian, Yang Huiyi, Ma Liping, Zhou Jiaxin. Effect of sinomenine on skin lesions in 2,4-dinitrochlorobenzene-induced atopic dermatitis-like mouse models [J]. Chinese Journal of Dermatology, 2025, 58(8): 759-766. |
[10] | Lin Jinran, Leong Hiochon, Liu Qingmei, Wu Wenyu. Androgenetic alopecia and metabolic syndrome: from mechanisms to treatment strategies [J]. Chinese Journal of Dermatology, 2025, 58(7): 591-594. |
[11] | Ding Weiyun, Lin Jinran, Liu Qingmei, Zhang Yue, Yang Kai, Ni Chunya, Wu Wenyu, . Role of stem cells in scalp aging and related therapeutic strategies [J]. Chinese Journal of Dermatology, 2025, 58(7): 671-675. |
[12] | Wang Qin, Lin Jinran, Liu Qingmei, Wu Wenyu, . Oral minoxidil in the treatment of alopecia areata [J]. Chinese Journal of Dermatology, 2025, 58(7): 653-656. |
[13] | Hair Research Group, Chinese Society of Dermatology. Chinese expert consensus on the diagnosis and treatment of lichen planopilaris/frontal fibrosing alopecia (2025 edition) [J]. Chinese Journal of Dermatology, 2025, 58(7): 583-590. |
[14] | Li Yu, Wang Ziwei, Ye Rongjia, Li Rong, Zhu Yan, Zhang Xiaohua, Huang Dan, Ju Mei. Home-based phototherapy implementation and management needs in patients with vitiligo: a questionnaire survey analysis [J]. Chinese Journal of Dermatology, 2025, 58(7): 608-612. |
[15] | Zhang Li, Song Xiuzu. Role of vascular endothelial growth factor in androgenetic alopecia [J]. Chinese Journal of Dermatology, 2025, 58(7): 683-685. |
|