间充质干细胞来源的外泌体在皮肤病中的作用

doi:10.35541/cjd.20220881

Abstract

Abstract: 【Abstract】 Mesenchymal stem cells are pluripotent stem cells with the potential to differentiate into various types of cells. Many studies have shown that mesenchymal stem cells primarily exert their biological functions through paracrine effects, which can be mediated by exosomes. Exosomes can carry DNA, RNA, lipids, and proteins, and introduce them into recipient cells to produce various biological effects. In recent years, a lot of studies have confirmed the therapeutic effects of mesenchymal stem cell?derived exosomes from various sources on skin diseases. This review summarizes the biological characteristics and functions of mesenchymal stem cell-derived exosomes and their roles in the treatment of skin diseases.

Key words: Exosomes, Mesenchymal stem cells, Therapy, Lupus erythematosus, systemic, Dermatitis, atopic, Psoriasis

Xu Zhuohong, Hu Yu, Gu Heng. Role of mesenchymal stem cell-derived exosomes in skin diseases[J]. Chinese Journal of Dermatology,2025,e20220881. doi:10.35541/cjd.20220881

References ［39］

［1］	Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells［J］. Science, 1999,284（5411）:143⁃147. doi: 10.1126/science.284.5411.143.
［2］	Xunian Z, Kalluri R. Biology and therapeutic potential of mesenchymal stem cell⁃derived exosomes［J］. Cancer Sci, 2020,111（9）:3100⁃3110. doi: 10.1111/cas.14563.
［3］	Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes［J］. Science, 2020,367（6478）:eaau6977. doi: 10.1126/science.aau6977.
［4］	Kusuma GD, Barabadi M, Tan JL, et al. To Protect and to preserve: novel preservation strategies for extracellular vesicles［J］. Front Pharmacol, 2018,9:1199. doi: 10.3389/fphar.2018. 01199.
［5］	Chen J, Chen J, Cheng Y, et al. Mesenchymal stem cell⁃derived exosomes protect beta cells against hypoxia⁃induced apoptosis via miR⁃21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation［J］. Stem Cell Res Ther, 2020,11（1）:97. doi: 10.1186/s13287⁃020⁃01610⁃0.
［6］	Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: a novel stem cell⁃based therapy for cardiovascular disease［J］. Regen Med, 2011,6（4）:481⁃492. doi: 10.2217/rme.11.35.
［7］	Sipos F, Mzes G. Controversies in therapeutic application of mesenchymal stem cell⁃derived secretome［J］. BIOCELL, 2022, 46（4）: 4.doi: 10.32604/biocell.2022.018200.
［8］	Toh WS, Lai RC, Zhang B, et al. MSC exosome works through a protein⁃based mechanism of action［J］. Biochem Soc Trans, 2018,46（4）:843⁃853. doi: 10.1042/BST20180079.
［9］	Tang XD, Shi L, Monsel A, et al. Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang⁃1 mRNA［J］. Stem Cells, 2017,35（7）:1849⁃1859. doi: 10.1002/stem.2619.
［10］	Katsuda T, Ochiya T. Molecular signatures of mesenchymal stem cell⁃derived extracellular vesicle⁃mediated tissue repair［J］. Stem Cell Res Ther, 2015,6:212. doi: 10.1186/s13287⁃015⁃0214⁃y.
［11］	Ge L, Xun C, Li W, et al. Extracellular vesicles derived from hypoxia⁃preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR⁃612［J］. J Nanobiotechnology, 2021,19（1）:380. doi: 10.1186/s12951⁃021⁃01126⁃6.
［12］	Tavasolian F, Hosseini AZ, Soudi S, et al. miRNA⁃146a improves immunomodulatory effects of MSC⁃derived exosomes in rheumatoid arthritis［J］. Curr Gene Ther, 2020,20（4）:297⁃312. doi: 10.2174/1566523220666200916120708.
［13］	Zhang Y, Pan Y, Liu Y, et al. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor⁃β receptor inhibition［J］. Stem Cell Res Ther, 2021,12（1）:434. doi: 10.1186/s13287⁃021⁃02517⁃0.
［14］	Gezer U, Özgür E, Cetinkaya M, et al. Long non⁃coding RNAs with low expression levels in cells are enriched in secreted exosomes［J］. Cell Biol Int, 2014,38（9）:1076⁃1079. doi: 10. 1002/cbin.10301.
［15］	Li B, Luan S, Chen J, et al. The MSC⁃derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via microRNA⁃152⁃3p［J］. Mol Ther Nucleic Acids, 2020,19:814⁃826. doi: 10.1016/j.omtn.2019.11.034.
［16］	Dou R, Zhang X, Xu X, et al. Mesenchymal stem cell exosomal tsRNA⁃21109 alleviate systemic lupus erythematosus by inhibiting macrophage M1 polarization［J］. Mol Immunol, 2021,139:106⁃114. doi: 10.1016/j.molimm.2021.08.015.
［17］	Lai RC, Tan SS, Teh BJ, et al. Proteolytic potential of the MSC exosome proteome: implications for an exosome⁃mediated delivery of therapeutic proteasome［J］. Int J Proteomics, 2012,2012:971907. doi: 10.1155/2012/971907.
［18］	Zhang B, Wang M, Gong A, et al. HucMSC⁃exosome mediated⁃Wnt4 signaling is required for cutaneous wound healing［J］. Stem Cells, 2015,33（7）:2158⁃2168. doi: 10.1002/stem.1771.
［19］	Zhang B, Shi Y, Gong A, et al. HucMSC exosome⁃delivered 14⁃3⁃3ζ orchestrates self⁃control of the Wnt response via modulation of YAP during cutaneous regeneration［J］. Stem Cells, 2016,34（10）:2485⁃2500. doi: 10.1002/stem.2432.
［20］	Shabbir A, Cox A, Rodriguez⁃Menocal L, et al. Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro［J］. Stem Cells Dev, 2015,24（14）:1635⁃1647. doi: 10.1089/scd. 2014.0316.
［21］	Liu H, Liang Z, Wang F, et al. Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage⁃ dependent mechanism［J］. JCI Insight, 2019,4（24）:e131273. doi: 10.1172/jci.insight.131273.
［22］	Yang S, Liang X, Song J, et al. A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG⁃6［J］. Stem Cell Res Ther, 2021,12（1）:315. doi: 10.1186/s13287⁃021⁃02404⁃8.
［23］	Ha DH, Kim HK, Lee J, et al. Mesenchymal stem/stromal cell⁃derived exosomes for immunomodulatory therapeutics and skin regeneration［J］. Cells, 2020,9（5）:1157. doi: 10.3390/cells9051157.
［24］	Silachev DN, Goryunov KV, Shpilyuk MA, et al. Effect of MSCs and MSC⁃derived extracellular vesicles on human blood coagulation［J］. Cells, 2019,8（3）:258. doi: 10.3390/cells803 0258.
［25］	夏娜, 高超, 刘璇, 等. 脐带间充质干细胞外泌体对急性皮肤创面愈合的初步研究［J］.中华皮肤科杂志, 2022,55（5）:382⁃388. doi: 10.35541/cjd.20210831.
［26］	Zhao W, Zhang R, Zang C, et al. Exosome derived from mesenchymal stem cells alleviates pathological scars by inhibiting the proliferation, migration and protein expression of fibroblasts via delivering miR⁃138⁃5p to target SIRT1［J］. Int J Nanomedicine, 2022,17:4023⁃4038. doi: 10.2147/IJN.S377317.
［27］	Yang C, Sun J, Tian Y, et al. Immunomodulatory effect of MSCs and MSCs⁃derived extracellular vesicles in systemic lupus erythematosus［J］. Front Immunol, 2021,12:714832. doi: 10. 3389/fimmu.2021.714832.
［28］	Bolandi Z, Mokhberian N, Eftekhary M, et al. Adipose derived mesenchymal stem cell exosomes loaded with miR⁃10a promote the differentiation of Th17 and Treg from naive CD4（+） T cell［J］. Life Sci, 2020,259:118218. doi: 10.1016/j.lfs.2020.118218.
［29］	Adamo A, Brandi J, Caligola S, et al. Extracellular vesicles mediate mesenchymal stromal cell⁃dependent regulation of B cell PI3K⁃AKT signaling pathway and actin cytoskeleton［J］. Front Immunol, 2019,10:446. doi: 10.3389/fimmu.2019.00446.
［30］	Shahir M, Mahmoud Hashemi S, Asadirad A, et al. Effect of mesenchymal stem cell⁃derived exosomes on the induction of mouse tolerogenic dendritic cells［J］. J Cell Physiol, 2020,235（10）:7043⁃7055. doi: 10.1002/jcp.29601.
［31］	Dong B, Wang C, Zhang J, et al. Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid⁃resistant asthma by reshaping macrophage polarization［J］. Stem Cell Res Ther, 2021,12（1）:204. doi: 10. 1186/s13287⁃021⁃02244⁃6.
［32］	Ye Z, Liang Y, Lin B, et al. Gingiva⁃derived mesenchymal stem cells attenuate imiquimod⁃ （IMQ⁃） induced murine psoriasis⁃like skin inflammation［J］. Stem Cells Int, 2022,2022:6544514. doi: 10.1155/2022/6544514.
［33］	韩齐心, 牛旭平, 刘佳, 等. 间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展［J］.中华皮肤科杂志, 2020,53（2）:151⁃154. doi: 10.35541/cjd.20190012.
［34］	Ghoreschi K, Balato A, Enerbäck C, et al. Therapeutics targeting the IL⁃23 and IL⁃17 pathway in psoriasis［J］. Lancet, 2021,397（10275）:754⁃766. doi: 10.1016/S0140⁃6736（21）00184⁃7.
［35］	Xu F, Fei Z, Dai H, et al. Mesenchymal stem cell⁃derived extracellular vesicles with high PD⁃L1 Expression for Autoimmune Diseases Treatment［J］. Adv Mater, 2022,34（1）:e2106265. doi: 10.1002/adma.202106265.
［36］	Shin KO, Ha DH, Kim JO, et al. Exosomes from human adipose tissue⁃derived mesenchymal stem cells promote epidermal barrier repair by inducing de novo synthesis of ceramides in atopic dermatitis［J］. Cells, 2020,9（3）:680. doi: 10.3390/cells 9030680.
［37］	Deng M, Yu TZ, Li D, et al. Human umbilical cord mesenchymal stem cell⁃derived and dermal fibroblast⁃derived extracellular vesicles protect dermal fibroblasts from ultraviolet radiation⁃induced photoaging in vitro［J］. Photochem Photobiol Sci, 2020,19（3）:406⁃414. doi: 10.1039/c9pp00421a.
［38］	Zhang K, Yu L, Li FR, et al. Topical application of exosomes derived from human umbilical cord mesenchymal stem cells in combination with sponge spicules for treatment of photoaging［J］. Int J Nanomedicine, 2020,15:2859⁃2872. doi: 10.2147/IJN.S249751.
［39］	Ding Q, Sun R, Wang P, et al. Protective effects of human induced pluripotent stem cell⁃derived exosomes on high glucose⁃induced injury in human endothelial cells［J］. Exp Ther Med, 2018,15（6）:4791⁃4797. doi: 10.3892/etm.2018.6059.

[1]	Huang Jinjin, Li Zhuqing, Lu Juanjuan, Li Shuhua, Cao Zhe, Xu Donghua, Wang Guoying, . Role of nucleotide-binding oligomerization domain-like receptor protein 3 in the pathogenesis of androgenetic alopecia and therapeutic advances [J]. Chinese Journal of Dermatology, 2026, 59(8): 802-805.
[2]	Li Yanhong, Jiang Kun, Wu Zhuoxuan, Zhang Jianlan, Fang Meizhen, Liu Shuting, Wang Linlin, Hu Lei, Zhou Xiaoyong, Chen Liuqing, Chen Jinbo. Analysis of 18 cases of cutaneous adverse reactions associated with programmed death-1 inhibitors [J]. Chinese Journal of Dermatology, 2026, 59(8): 783-787.
[3]	Expert Group on the “Chinese expert consensus on sirolimus in the treatment of Kaposiform hemangioendothelioma （ edition）”. Chinese expert consensus on sirolimus in the treatment of Kaposiform hemangioendothelioma （2026 edition） [J]. Chinese Journal of Dermatology, 2026, 59(8): 728-737.
[4]	Shi Rongcan¹, ², Yu Zengyang², ³, Luo Qingqiong², Ma Rui¹, ², Jiang Xingyu¹, ², Wang Yuanyuan¹, ², Cai Jiangluyi¹, ², Shi Yuling¹, ². Palmitoyl-proteomic profiles of psoriatic lesions and their role in inflammatory responses: a preliminary study [J]. Chinese Journal of Dermatology, 2026, 59(8): 738-749.
[5]	Writing Committee Expert Group on “Diagnosis and treatment of pustular psoriasis: a Chinese expert consensus statement （ edition）”. Diagnosis and treatment of pustular psoriasis: a Chinese expert consensus statement （2026 edition） [J]. Chinese Journal of Dermatology, 2026, 59(8): 717-727.
[6]	Wei Jin¹, Yan Huiwen¹, Zhang Jianzhong², Lun Wenhui¹. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis complicated by HIV infection: a clinical observation of 10 cases [J]. Chinese Journal of Dermatology, 2026, 59(7): 671-674.
[7]	Wang Linlin, Cao Lijuan, Chen Liuqing, Li Dongsheng, Hu Yanyan. Efficacy and safety of hemoporfin-mediated photodynamic therapy for port-wine stains on the extremities: a retrospective analysis [J]. Chinese Journal of Dermatology, 2026, 59(7): 637-644.
[8]	Zubaidanmu Aizezi¹, Yi Lei², Aikedai Yusufu³, Tursunnayi Manafu⁴, Liu Dandan⁴, Yang Yi⁵, Wang Xiaodong¹. Antioxidant and protective effects of M2 macrophage-derived exosomes against photoaging in human skin fibroblasts [J]. Chinese Journal of Dermatology, 2026, 59(7): 662-670.
[9]	Yuwen Tianyi¹, Zhou Zizhen¹, Tian Jingyu¹, Chen Sihan², Li Min², Zhang Fengyuan¹, Gu Heng, ², Chen Xu, ². Expression of the glutaminase 1/ammonia metabolism axis in keratinocytes in ultraviolet B-induced acute skin injury and psoriatic skin inflammation [J]. Chinese Journal of Dermatology, 2026, 59(7): 654-661.
[10]	Zhang Guolong, Zhao Zijun. Aminolevulinic acid-based photodynamic therapy for cutaneous squamous cell carcinoma: current status, challenges, and perspectives [J]. Chinese Journal of Dermatology, 2026, 59(7): 626-631.
[11]	Hu Yu, Lu Yan, Chen Kun, Gu Heng. Standardization, precision, and full-cycle management: interpretation of Specifications for the Management of Vitiligo Patients Undergoing Home Phototherapy [J]. Chinese Journal of Dermatology, 2026, 59(7): 632-636.
[12]	Dermatology Professional Committee of Chinese Research Hospital Society, China Dermatologist Association. Guideline for the clinical application of narrowband ultraviolet B phototherapy in dermatology （2026 edition） [J]. Chinese Journal of Dermatology, 2026, 59(7): 595-610.
[13]	Photodynamic Therapy Research Cooperative Group, Chinese Society of Dermatology, Chinese Association of Rehabilitation Dermatology & Photodynamic Therapy, Photomedicine Therapeutic Equipment Group, Committee on Skin Disease and Cosmetic Dermatology, China Association of Medical Equipment. Guideline for the clinical application of aminolevulinic acid-based photodynamic therapy in the treatment of condyloma acuminatum （2026 edition） [J]. Chinese Journal of Dermatology, 2026, 59(7): 611-618.
[14]	Pediatric Dermatology Group, Chinese Society of Dermatology, Dermatology Group, Chinese Pediatric Society, Chinese Medical Association, Pediatric Group, Chinese Association of Rehabilitation Dermatology, Atopic Dermatitis Group, Chinese Association of Rehabilitation Dermatology, Pediatric Dermatology Group, China Dermatologist Association, Dermatology Group, the Society of Pediatrics, Chinese Medical Doctor Association. Chinese consensus on the prevention, treatment, and management of atopic dermatitis in children（2026 edition） [J]. Chinese Journal of Dermatology, 2026, 59(6): 487-504.
[15]	Sun Songpeng, Long Junhong, Cao Bo, Xu Yue, Zhang Xiang′an, Cao Hui, Xie Jun, Gui Ping, Sun Xiaojun, Zhang Bo, Xu Zhijie, Li Jin′an, Wang Zhigang, Wu Wei, Yang Huiju, Wei Ping, Liu Congcong, Shen Qingbo, Yu Fan, Chu Hongchuan, Zhou Yangyang, Liu Jiaxin, Liu Yan, Huo Xingxiao, Chen Hang, Jing Tao, Gao Jing, Wang Yanxun, Wang Rui, Li Zhenyu, Zhang Shuxin. Efficacy and safety of Fuzhiqing ointment versus triamcinolone acetonide and econazole nitrate cream in the treatment of chronic perianal eczema: a multicenter, randomized, double-blind, controlled, equivalence trial [J]. Chinese Journal of Dermatology, 2026, 59(6): 564-570.

Role of mesenchymal stem cell-derived exosomes in skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［39］

Related Articles 15

Metrics

Comments

Recommended 10