Chinese Journal of Dermatology ›› 2023, e20220078.doi: 10.35541/cjd.20220078

• Reviews • Previous Articles     Next Articles

Pathogenesis of nail damages secondary to systemic diseases

Jiang Jiayi, Wang Daguang   

  1. Department of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
  • Received:2022-02-07 Revised:2022-06-27 Online:2023-01-05 Published:2023-07-31
  • Contact: Wang Daguang
  • Supported by:
    National Natural Science Foundation of China (81000703, 81472896); Natural Science Foundation of Jiangsu Province (BK2009437); Six Talent Peaks of Jiangsu Province (2015-WSW-026)

Abstract: 【Abstract】 Many nail changes have been found to be associated with systemic diseases, such as acropachy, koilonychia, splinter hemorrhages, leukonychia, yellow nail syndrome, Beau′s lines, etc., so they may provide clues for the diagnosis of systemic disorders. However, studies on nail damages secondary to systemic diseases are rare, and their pathogenesis is still unclear. This review summarizes the progress in the pathogenesis of nail damages in systemic diseases, so as to improve their diagnosis and treatment.

Key words: Nail diseases, Nail clubbing, Yellow nail syndrome, Koilonychia, Splinter hemorrhages, Systemic diseases, Pathogenesis