Chinese Journal of Dermatology ›› 2023, e20220588.doi: 10.35541/cjd.20220588

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Pathogenesis of extramammary Paget′s disease

Ding Meilin, Li Hongyang, Zhang Wei, Zeng Xuesi   

  1. Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China 
  • Received:2022-08-24 Revised:2023-04-05 Online:2023-01-05 Published:2023-07-12
  • Contact: Zhang Wei
  • Supported by:
    CAMS Innovation Fund for Medical Sciences (2020-I2M-C&T-B-091); Natural Science Foundation of Tibet Autonomous Region [XZ2021ZR-ZY12(Z)]

Abstract: 【Abstract】 Extramammary Paget′s disease (EMPD) usually occurs in the apocrine gland-bearing areas, in which Paget cells are scattered in the middle and lower epidermis, arranged singly or in clusters, and spread to all skin layers. The pathogenesis of EMPD is still unclear, and the origin of Paget cells remains controversial. This review discusses the pathogenesis of EMPD from 4 aspects, i.e., histogenesis, driver genes, signal transduction pathways and immune environment, and focuses on relevant research progress.

Key words: Paget disease, extramammary, Pathogenesis, Histogenesis, Driver genes, Signal transduction pathways, Immune environment