Chinese Journal of Dermatology ›› 2024, Vol. 57 ›› Issue (4): 374-378.doi: 10.35541/cjd.20210248

• Reviews • Previous Articles     Next Articles

Pathogenesis and targeted therapy of pemphigus

Yan Rufan1, Liao Jieyue2, Guo Ziyu2, Yao Nan2, Zhou Wenyu2, Luo Shuaihantian2, Zhang Guiying2, Zhao Ming2   

  1. 1Shenzhen Baoan Shiyan People′s Hospital, Shenzhen 518000, Guangdong,China; 2Department of Dermatology, the Second Xiangya Hospital of Central South University, Changsha 410011, China
  • Received:2021-03-24 Revised:2021-12-22 Online:2024-04-15 Published:2024-04-07
  • Contact: Luo Shuaihantian; Zhang Guiying; lindazgy@
  • Supported by:
    National Natural Science Foundation of China(81703133); Natural Science Foundation of Hunan Province of China (2019JJ40448, 2021JJ40856)

Abstract: 【Abstract】 In recent years, with the in-depth study of pemphigus, new pathogenesis has been identified based on the desmoglein antibody-mediated immune response mechanism, and new progress has been made in targeted therapy. This review summarizes recent advances in the pathogenesis and targeted therapy of pemphigus.

Key words: Pemphigus, Molecular targeted therapy, Biological agents, Pathogenesis