Chinese Journal of Dermatology ›› 2024, Vol. 57 ›› Issue (7): 661-664.doi: 10.35541/cjd.20240052

• Reviews • Previous Articles     Next Articles

Port-wine stains: mechanisms underlying the development and progression

Chen Haotian, Liu Lian, Zhang Ting, Liu Qingfeng, Li Xiaoxue, Diao Ping, Jiang Xian   

  1. Department of Dermatology and Venereology, West China Hospital, Sichuan University; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, Sichuan University, Chengdu 610041, China
  • Received:2024-01-26 Revised:2024-04-23 Online:2024-07-15 Published:2024-07-02
  • Contact: Jiang Xian E-mail:jiangxian@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China (82003373); 1.3.5 Project of Discipline Excellence Development of West China Hospital of Sichuan University (ZYJC21036)

Abstract: 【Abstract】 Port-wine stains (PWS) are vascular malformations characterized by dilated capillaries and postcapillary venules in the skin. Clinically, they mainly manifest as pink or red irregular patches, most of which may become thickened, darkened in color, or even develop into nodules over age, making treatment more challenging. The mechanisms underlying the development and progression of PWS are not very clear, and may be related to heredity, gene mutations, abnormal ratios of blood vessels to nerves, etc. This review summarizes research progress in the mechanisms underlying the development and progression of PWS, so as to provide a theoretical basis for their treatment.

Key words: Port-wine stain, Vascular malformations, Therapy, Pathogenesis, Disease progression