Abstract: 【Abstract】 Objective To investigate the clinical efficacy of salt-packing therapy in the treatment of pyogenic granuloma. Methods A retrospective analysis was conducted on the clinical data from 25 patients with pyogenic granuloma receiving salt-packing therapy at the Department of Dermatology, Shanghai Changzheng Hospital between January 2021 and August 2023. After treatment, the improvement of skin lesions was evaluated, and adverse reactions and recurrent attacks of skin lesions were recorded. The Spearman correlation coefficients were used to identify factors affecting the treatment duration. Results Of the 25 patients with pyogenic granuloma, 6 were males and 19 were females, with ages ranging from 19 to 61 years （35 ± 9 years）. However, two patients underwent alternative treatments after 1-week salt-packing therapy, and 1 was lost to follow-up, none of whom were included in the efficacy analysis. At week 1 after the start of salt-packing therapy, 3 of 22 patients （13.6%） achieved complete recovery, 10 （45.5%） exhibited marked improvement, and 5 （22.7%） achieved improvement, resulting in a response rate of 81.8%; at week 2, 14 （63.6%） were cured, 2 （9.1%） showed marked improvement, and 4 （18.2%） achieved improvement, leading to a notable response rate of 90.9%; at 1 month, 20 （90.9%） were cured, 1 （4.5%） achieved marked improvement, resulting in an impressive response rate of 95.5%; at 3 months, 21 （95.5%） were fully cured, and 1 achieved improvement, resulting in a response rate of 100%. Among the 21 patients who completed the therapy, the treatment duration ranged from 6 to 41 days, and the recovery time was 15.3 ± 9.3 days; besides, 1 patient still underwent treatment at the time of analysis. Moreover, the recovery time exhibited a positive correlation with the lesion size （r = 0.62, P = 0.003）, but was not correlated with the age and disease duration. Only 1 case experienced a recurrence during 3 months of follow-up after complete recovery. Throughout the treatment duration, 4 patients reported varying degrees of pain and burning sensation, 1 of whom reported intolerable pain. Conclusion Salt-packing therapy is worthy of clinical promotion and application in the treatment of pyogenic granuloma, due to simple operation and definite therapeutic efficacy.

Key words: Granuloma, pyogenic, Sodium chloride, dietary, Treatment outcome, Packing therapy