Abstract: 【Abstract】 Objective To analyze clinical efficacy and safety of dermabrasion for the treatment of familial benign chronic pemphigus. Methods Clinical data were retrospectively collected from 6 patients with familial benign chronic pemphigus, who underwent dermabrasion in the Department of Dermatology, the First Affiliated Hospital of Dalian Medical University from February 2019 to July 2020. There were 3 males and 3 females, they were aged from 39 to 65 years, and their disease duration ranged from 10 to 40 years. All the patients were postoperatively followed up for 14 - 34 months. Response rates were calculated, and adverse reactions and recurrence were observed. Results Dermabrasion was performed on the 6 patients in 55 body areas. After operation, complete recovery was achieved in 36 areas （65.5%）, marked improvement was noted in 13 areas （23.6%）, and moderate improvement was observed in 6 areas （10.9%）; there were no areas with no response, resulting in an overall response rate of 89.1%. Postoperatively, the patients experienced no obvious discomfort, and only slight hypopigmentation and scars remained. During the follow-up of 14 to 34 months, no recurrence was observed in the treated areas. Conclusion Dermabrasion was safe and effective for the treatment of familial benign chronic pemphigus.

Key words: Pemphigus, benign familial, Dermabrasion, Surgical procedures, operative, Pathologic processes, Recurrence, Treatment outcome