Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (5): 459-462.doi: 10.35541/cjd.20210072

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Symbiotic homeostasis of Staphylococcus epidermidis is associated with common skin disorders

Li Jiaqi, Ye Feng, Ju Qiang   

  1. Department of Dermatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
  • Received:2021-01-26 Revised:2021-09-05 Online:2023-05-15 Published:2023-05-04
  • Contact: Ju Qiang
  • Supported by:
    National Natural Science Foundation of China(81874247)

Abstract: 【Abstract】 Staphylococcus epidermidis can exhibit both protective and opportunistic pathogenic effects on the skin: on the one hand, it suppresses pathogenic bacteria and inflammation, assists the innate immune system of the skin, and maintains homeostasis of skin microenvironment; on the other hand, it exhibits pathogenic potential. How Staphylococcus epidermidis will affect human skin conditions depends not only on itself, but also on the communication among it, the host immune system, other microorganisms and environment factors. The balance of this interaction is the symbiotic homeostasis of Staphylococcus epidermidis, and when the homeostasis is disrupted, a variety of skin diseases such as acne vulgaris, atopic dermatitis, rosacea and melanoma can occur. Factors affecting the symbiotic homeostasis of Staphylococcus epidermidis include environmental conditions such as temperature, oxygen content and nutrition, antibiotics, the number of other microorganisms, microecological diversity, etc. This review summarizes recent research progress in symbiotic homeostasis of Staphylococcus epidermidis.

Key words: Staphylococcus epidermidis, Microbial consortia, Acne vulgaris, Dermatitis, atopic, Rosacea, Nevi and melanoma, Host microbial interactions