复发痣的研究进展

doi:10.35541/cjd.20220431

Abstract

Abstract: 【Abstract】 Recurrent melanocytic nevus, also known as pseudomelanoma, is recurrence of melanocytic nevus after incomplete removal. Recurrent melanocytic nevus is often characterized by asymmetric and irregularly circumscribed pigmentation, and it needs to be differentiated from melanoma. Currently, there are few studies on recurrent melanocytic nevus in China and other countries. This review summarizes research advances in recurrent melanocytic nevus, and mainly describes its clinical features, histopathological and immunohistochemical characteristics, differential diagnosis, and possible etiology, in order to provide a reference for clinical diagnosis and treatment of recurrent melanocytic nevus.

Key words: Melanocytic nevi, Recurrent melanocytic nevi, Nevi and melanomas, Pathologic processes

Li Fang, Wang Xiaoqing, Liu Mengxi, Jiang Jiayi, Huang Shudai, Wang Daguang. Research advances in recurrent melanocytic nevus[J]. Chinese Journal of Dermatology,2023,e20220431. doi:10.35541/cjd.20220431

References ［37］

［1］	Kornberg R, Ackerman AB. Pseudomelanoma: recurrent melanocytic nevus following partial surgical removal［J］. Arch Dermatol, 1975,111（12）:1588⁃1590. doi: 10.1001/archderm.111. 12.1588.
［2］	Vilain RE, McCarthy SW, Scolyer RA. The regenerating naevus［J］. Pathology, 2016,48（2）:108⁃112. doi: 10.1016/j.pathol.2015. 12.009.
［3］	Castagna RD, Stramari JM, Chemello R. The recurrent nevus phenomenon［J］. An Bras Dermatol, 2017,92（4）:531⁃533. doi: 10.1590/abd1806⁃4841.20176190.
［4］	Oh Y, Lee SH, Lim JM, et al. Long⁃term outcomes of laser treatment for congenital melanocytic nevi［J］. J Am Acad Dermatol, 2019,80（2）:523⁃531.e12. doi: 10.1016/j.jaad.2018.08. 046.
［5］	Köse O. Efficacy of the carbon dioxide fractional laser in the treatment of compound and dermal facial nevi using with dermatoscopic follow⁃up［J］. J Dermatolog Treat, 2019,30（5）:498⁃502. doi: 10.1080/09546634.2018.1529384.
［6］	King R, Hayzen BA, Page RN, et al. Recurrent nevus phenomenon: a clinicopathologic study of 357 cases and histologic comparison with melanoma with regression［J］. Mod Pathol, 2009,22（5）:611⁃617. doi: 10.1038/modpathol.2009.22.
［7］	Fox JC, Reed JA, Shea CR. The recurrent nevus phenomenon: a history of challenge, controversy, and discovery［J］. Arch Pathol Lab Med, 2011,135（7）:842⁃846. doi: 10.5858/2010⁃0429⁃RAR.1.
［8］	Heck R, Ferrari T, Cartell A, et al. Clinical and dermoscopic （in vivo and ex vivo） predictors of recurrent nevi［J］. Eur J Dermatol, 2019,29（2）:179⁃184. doi: 10.1684/ejd.2019.3530.
［9］	Blum A, Hofmann⁃Wellenhof R, Marghoob AA, et al. Recurrent melanocytic nevi and melanomas in dermoscopy: results of a multicenter study of the International Dermoscopy Society［J］. JAMA Dermatol, 2014,150（2）:138⁃145. doi: 10.1001/jamadermatol.2013.6908.
［10］	Sommer LL, Barcia SM, Clarke LE, et al. Persistent melanocytic nevi: a review and analysis of 205 cases［J］. J Cutan Pathol, 2011,38（6）:503⁃507. doi: 10.1111/j.1600⁃0560.2011.01692.x.
［11］	Hoang MP, Prieto VG, Burchette JL, et al. Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation［J］. J Cutan Pathol, 2001,28（8）:400⁃406. doi: 10.1034/j.1600⁃0560. 2001.028008400.x.
［12］	Tschandl P. Recurrent nevi: report of three cases with dermatoscopic⁃dermatopathologic correlation［J］. Dermatol Pract Concept, 2013,3（1）:29⁃32. doi: 10.5826/dpc.0301a08.
［13］	Helm TN, Helm MF, Helm KF. Melanoma arising in a persistent nevus: melanoma where‘seudomelanoma′is expected［J］. JAAD Case Rep, 2021,12:5⁃7. doi: 10.1016/j.jdcr.2021.03.045.
［14］	Pogorzelska⁃Dyrbuś J, Bergler⁃Czop B, Kajor M. Recurrence of melanoma in the scar after excised Spitz nevus in a 17⁃year⁃old child［J］. An Bras Dermatol, 2021,96（4）:451⁃453. doi: 10.1016/j.abd.2020.07.014.
［15］	Jeong DK, Bae YC, Lee SJ, et al. A case of malignant melanoma after repeated recurrent dysplastic nevi［J］. Arch Craniofac Surg, 2019,20（4）:260⁃264. doi: 10.7181/acfs.2019.00283.
［16］	Walton KE, Garfield EM, Zhang B, et al. The role of TERT promoter mutations in differentiating recurrent nevi from recurrent melanomas: a retrospective, case⁃control study［J］. J Am Acad Dermatol, 2019,80（3）:685⁃693. doi: 10.1016/j.jaad. 2018.09.030.
［17］	LeBoit PE. The morphology of tumor progression in melanoma in situ［J］. JAMA Dermatol, 2019,155（7）:775⁃776. doi: 10.1001/jamadermatol.2019.0457.
［18］	Fleming NH, Shaub AR, Bailey E, et al. Outcomes of surgical re⁃excision versus observation of severely dysplastic nevi: a single⁃institution, retrospective cohort study［J］. J Am Acad Dermatol, 2020,82（1）:238⁃240. doi: 10.1016/j.jaad.2019.07.033.
［19］	Moreno A, Manrique⁃Silva E, Virós A, et al. Histologic features associated with an invasive component in lentigo maligna lesions［J］. JAMA Dermatol, 2019,155（7）:782⁃788. doi: 10.1001/jamadermatol.2019.0467.
［20］	Bsirini C, Smoller BR. Histologic mimics of malignant melanoma［J］. Singapore Med J, 2018,59（11）:602⁃607. doi: 10.11622/smedj.2018041.
［21］	Dass SE, Huizenga T, Farshchian M, et al. Comparison of SOX⁃10, HMB⁃45, and melan⁃A in benign melanocytic lesions［J］. Clin Cosmet Investig Dermatol, 2021,14:1419⁃1425. doi: 10. 2147/CCID.S333376.
［22］	Santandrea G, Valli R, Zanetti E, et al. Comparative analysis of PRAME expression in 127 acral and nail melanocytic lesions［J］. Am J Surg Pathol, 2022,46（5）:579⁃590. doi: 10.1097/PAS. 0000000000001878.
［23］	Krajisnik A, Gharavi NM, Faries MB, et al. Immunohisto⁃chemistry for preferentially expressed antigen in melanoma in the differential diagnosis of melanocytic lesions of the nail apparatus［J］. Am J Dermatopathol, 2022,44（7）:488⁃492. doi: 10.1097/DAD.0000000000002143.
［24］	Lezcano C, Jungbluth AA, Nehal KS, et al. PRAME expression in melanocytic tumors［J］. Am J Surg Pathol, 2018,42（11）:1456⁃1465. doi: 10.1097/PAS.0000000000001134.
［25］	Googe PB, Flanigan KL, Miedema JR. Preferentially expressed antigen in melanoma immunostaining in a series of melanocytic neoplasms［J］. Am J Dermatopathol, 2021,43（11）:794⁃800. doi: 10.1097/DAD.0000000000001885.
［26］	Raghavan SS, Wang JY, Kwok S, et al. PRAME expression in melanocytic proliferations with intermediate histopathologic or spitzoid features［J］. J Cutan Pathol, 2020,47（12）:1123⁃1131. doi: 10.1111/cup.13818.
［27］	Ko JS, Matharoo⁃Ball B, Billings SD, et al. Diagnostic distinction of malignant melanoma and benign nevi by a gene expression signature and correlation to clinical outcomes［J］. Cancer Epidemiol Biomarkers Prev, 2017,26（7）:1107⁃1113. doi: 10. 1158/1055⁃9965.EPI⁃16⁃0958.
［28］	Nishimura EK, Jordan SA, Oshima H, et al. Dominant role of the niche in melanocyte stem⁃cell fate determination［J］. Nature, 2002,416（6883）:854⁃860. doi: 10.1038/416854a.
［29］	Sun Q, Rabbani P, Takeo M, et al. Dissecting Wnt signaling for melanocyte regulation during wound healing［J］. J Invest Dermatol, 2018,138（7）:1591⁃1600. doi: 10.1016/j.jid.2018.01. 030.
［30］	Yardman⁃Frank JM, Fisher DE. Skin pigmentation and its control: from ultraviolet radiation to stem cells［J］. Exp Dermatol, 2021,30（4）:560⁃571. doi: 10.1111/exd.14260.
［31］	Hu S, Chen Y, Zhao B, et al. KIT is involved in melanocyte proliferation, apoptosis and melanogenesis in the Rex Rabbit［J］. PeerJ, 2020,8:e9402. doi: 10.7717/peerj.9402.
［32］	Sohn S, Kim S, Kang WH. Recurrent pigmented macules after q⁃switched alexandrite laser treatment of congenital melanocytic nevus［J］. Dermatol Surg, 2004,30（6）:898⁃907; discussion 907. doi: 10.1111/j.1524⁃4725.2004.30258.x.
［33］	D′Arcy C, Kiel C. Cell adhesion molecules in normal skin and melanoma［J］. Biomolecules, 2021,11（8）:1213. doi: 10.3390/biom11081213.
［34］	Li L, Fukunaga⁃Kalabis M, Yu H, et al. Human dermal stem cells differentiate into functional epidermal melanocytes［J］. J Cell Sci, 2010,123（Pt 6）:853⁃860. doi: 10.1242/jcs.061598.
［35］	Wang DG, Huang FR, Chen W, et al. Clinicopathological analysis of acquired melanocytic nevi and a preliminary study on the possible origin of nevus cells［J］. Am J Dermatopathol, 2020,42（6）:414⁃422. doi: 10.1097/DAD.0000000000001599.
［36］	Kunisada T, Yamazaki H, Hirobe T, et al. Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis［J］. Mech Dev, 2000,94（1⁃2）:67⁃78. doi: 10.1016/s0925⁃4773（00）00308⁃7.
［37］	Aoki H, Yamada Y, Hara A, et al. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non⁃cutaneous and dermal versus epidermal melanocytes［J］. Development, 2009,136（15）:2511⁃2521. doi: 10.1242/dev.037168.

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Research advances in recurrent melanocytic nevus

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