结缔组织痣的临床分型及组织病理研究进展

doi:10.35541/cjd.20200586

Abstract

Abstract: 【Abstract】 Connective tissue nevi （CTN）, a kind of benign skin hamartomas, can be classified into 3 types according to the excessive components predominating in skin lesions, including collagen type, elastin type and proteoglycan type, and each type of CTN includes various inherited and acquired diseases. Therefore, genetic, clinical, and histopathological features should be considered for confirmed diagnosis of CTN subtypes. According to the latest Chinese and international literature, this review elaborates clinical classification and histopathological characteristics of CTN, aiming to further strengthen the understanding of this disease.

Key words: Hamartoma, International classification of diseases, Pathologic processes, Connective tissue nevi

Wang Yifei, Song Hao, Miao Qiuju, Xu Xiulian, Sun Jianfang. Clinical classification and histopathological features of connective tissue nevi[J]. Chinese Journal of Dermatology, 2023, 56(1): 82-85.doi:10.35541/cjd.20200586

References ［22］

［1］	Uitto J, Santa Cruz DJ, Eisen AZ. Connective tissue nevi of the skin. Clinical, genetic, and histopathologic classification of hamartomas of the collagen, elastin, and proteoglycan type［J］. J Am Acad Dermatol, 1980,3（5）:441⁃461.
［2］	Arora H, Falto⁃Aizpurua L, Cortés⁃Fernandez A, et al. Connective tissue nevi: a review of the literature［J］. Am J Dermatopathol, 2017,39（5）:325⁃341. doi: 10.1097/DAD.00000 00000000638.
［3］	赵辨. 中国临床皮肤病学［M］. 2版. 南京: 江苏凤凰科学技术出版社, 2017:1235
［4］	Tarasewicz A, Dębska⁃Ślizień A, Rutkowska B, et al. Efficacy and safety of mammalian target of rapamycin inhibitor use⁃long⁃term follow⁃up of first tuberous sclerosis complex patient treated de novo with sirolimus after kidney transplantation: a case report［J］. Transplant Proc, 2018,50（6）:1904⁃1909. doi: 10.1016/j.transproceed.2018.03.028.
［5］	Keppler⁃Noreuil KM, Burton⁃Akright J, Lindhurst MJ, et al. Molecular heterogeneity of the cerebriform connective tissue nevus in mosaic overgrowth syndromes［J］. Cold Spring Harb Mol Case Stud, 2019,5（4）:a004036. doi: 10.1101/mcs.a004036.
［6］	Pithadia DJ, Roman JW, Sapp JC, et al. Hypertrichotic patches as a mosaic manifestation of Proteus syndrome［J］. J Am Acad Dermatol, 2021,84（2）:415⁃424. doi: 10.1016/j.jaad.2020.01.078.
［7］	Chen J, Chen L, Duan Y, et al. Cerebriform connective tissue nevus of lumbar［J］. J Dermatol, 2015,42（2）:219⁃220. doi: 10. 1111/1346⁃8138.12735.
［8］	Nathan NR, Patel R, Crenshaw MM, et al. Pathogenetic insights from quantification of the cerebriform connective tissue nevus in Proteus syndrome［J］. J Am Acad Dermatol, 2018,78（4）:725⁃732. doi: 10.1016/j.jaad.2017.10.018.
［9］	Nathan NR, Patel R, Crenshaw MM, et al. Pathogenetic insights from quantification of the cerebriform connective tissue nevus in Proteus syndrome［J］. J Am Acad Dermatol, 2018,78（4）:725⁃732. doi: 10.1016/j.jaad.2017.10.018.
［10］	Nathan NR, Patel R, Crenshaw MM, et al. Pathogenetic insights from quantification of the cerebriform connective tissue nevus in Proteus syndrome［J］. J Am Acad Dermatol, 2018,78（4）:725⁃732. doi: 10.1016/j.jaad.2017.10.018.
［11］	Ryder HF, Antaya RJ. Nevus anelasticus, papular elastorrhexis, and eruptive collagenoma: clinically similar entities with focal absence of elastic fibers in childhood［J］. Pediatr Dermatol, 2005,22（2）:153⁃157. doi: 10.1111/j.1525⁃1470.2005.22214.x.
［12］	Hellemans J, Preobrazhenska O, Willaert A, et al. Loss⁃of⁃function mutations in LEMD3 result in osteopoikilosis, Buschke⁃Ollendorff syndrome and melorheostosis［J］. Nat Genet, 2004,36（11）:1213⁃1218. doi: 10.1038/ng1453.
［13］	Velasco Huici R, Martín JM, Vázquez B, et al. Depressed indurated plaque with elastorrhexis as a distinctive lesion in Buschke⁃Ollendorff syndrome［J］. Pediatr Dermatol, 2020,37（2）:385⁃387. doi: 10.1111/pde.14096.
［14］	Schwartz IV, Ribeiro MG, Mota JG, et al. A clinical study of 77 patients with mucopolysaccharidosis type II［J］. Acta Paediatr, 2007,96（455）:63⁃70. doi: 10.1111/j.1651⁃2227.2007.00212.x.
［15］	Li SJ, Wu YY, Li W, et al. Ultrastructural observation in a case of mucinous nevus［J］. J Dtsch Dermatol Ges, 2018,16（6）:778⁃780. doi: 10.1111/ddg.13528.
［16］	阚婷会, 卢阳, 张颖, 等. 伴表皮增生的黏蛋白痣1例［J］. 中国皮肤性病学杂志, 2020,34（2）:189⁃190. doi: 10.13735/j.cjdv. 1001⁃7089.201903109.
［17］	于小平, 魏国. 黏蛋白痣一例并文献复习［J］. 中国麻风皮肤病杂志, 2019,35（3）:171⁃172.
［18］	Oiso N, Kimura M, Kawada A. Follicular mucinous nevus: a possible new variant of mucinous nevus［J］. J Am Acad Dermatol, 2014,71（4）:e141⁃e142. doi: 10.1016/j.jaad.2014.04.065.
［19］	Takahashi M, Matsuzaki Y, Nakano H, et al. Partial spontaneous regression of pediatric large fibroblastic connective tissue nevus［J］. J Dermatol, 2020,47（6）:e232⁃e234. doi: 10.1111/1346⁃8138.15320.
［20］	Bouaoud J, Fraitag S, Soupre V, et al. Congenital fibroblastic connective tissue nevi: unusual and misleading presentations in three infantile cases［J］. Pediatr Dermatol, 2018,35（5）:644⁃650. doi: 10.1111/pde.13571.
［21］	Saussine A, Marrou K, Delanoé P, et al. Connective tissue nevi: an entity revisited［J］. J Am Acad Dermatol, 2012,67（2）:233⁃239. doi: 10.1016/j.jaad.2011.08.008.
［22］	孟晓, 崔炳南, 徐怡嘉, 等. 皮肤镜和反射式共聚焦显微镜分析结缔组织痣一例［J］. 中华皮肤科杂志, 2018,51（6）:437⁃439. doi: 10.3760/cma.j.issn.0412⁃4030.2018.06.009.

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Clinical classification and histopathological features of connective tissue nevi

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