Abstract: 【Abstract】 Objective To analyze and summarize clinical and pathological characteristics of clear cell papulosis （CCP）. Methods Clinical data were collected from 57 children with CCP, who were diagnosed in Department of Dermatology, Children′s Hospital of Chongqing Medical University from November 2014 to March 2022, and their clinical and pathological characteristics were analyzed. Results Among the 57 patients, 30 were males and 27 were females; their age ranged from 6 months to 7 years and 10 months; the age at onset ranged from 1 to 74 months, and 39 （68.4%） experienced onset of disease in infancy; the course of disease ranged from 1 to 84 months. Skin lesions mainly manifested as millet- to soybean-sized roundish white macules or short bar-like white macules measuring 1 - 2 cm in length. Most patients （49 cases, 85.9%） had skin lesions less than 20 in number. The most common location of skin lesions was the lower abdomen（35 cases, 61.4%）, followed in turn by chest or upper abdomen （34 cases, 59.6%）, anterior axilla or armpit （17 cases, 29.8%）, and vulva （11 cases, 19.3%）. Short bar-like white macules predominated on the chest or upper abdomen （23/34, 65.7%） and anterior axilla or armpit （10/17）, roundish white macules predominated on the lower abdomen （30/35, 85.7%）, and the vulvar lesions all manifested as roundish white macules. Histopathological findings showed that slightly larger cells with abundant clear cytoplasm were scattered in or above the basal layer of the epidermis, and these cells were positive for cytokeratin 7, carcinoembryonic antigen, and periodic acid-Schiff staining. Conclusion CCP mainly occurred in young children, roundish white macules predominated on the lower abdomen and vulva, and short bar-like white macules predominated on the chest or upper abdomen, as well as on the anterior axilla or armpit, indicating that CCP has strongly identifiable clinical features.

Key words: Leukoplakia, Child, Skin manifestations, Pathologic processes, Clear cell papulosis, Clinical characteristics