Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (5): 446-449.doi: 10.35541/cjd.20200178

• Reviews • Previous Articles     Next Articles

Pathophysiological pathogenesis of rosacea

Song Xiaoting, Liu Bo, Chen Yudi, Zhao Zuotao   

  1. Department of Dermatology and Venereology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing 100034, China
  • Received:2020-02-26 Revised:2020-07-30 Online:2022-05-15 Published:2022-04-29
  • Contact: Zhao Zuotao E-mail:zhaozuotaotao@163.com
  • Supported by:
    Joint Sino-German Research Project of National Natural Science Foundation of China and DFG(GZ901)

Abstract: 【Abstract】 The pathogenesis of rosacea has not been fully elucidated. It is currently believed that genetic factors, local skin immune imbalance, neuroimmune and neurovascular dysfunction, skin barrier function abnormalities, microbiota imbalance, etc., are all involved in the occurrence and development of rosacea. This review summarizes research progress in the pathophysiological pathogenesis of rosacea.

Key words: Rosacea, Pathologic processes, Neuroimmunomodulation, Local immunological imbalance, Neuroimmunity, Skin barrier function