Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (4): 362-365.doi: 10.35541/cjd.20210298

• Reviews • Previous Articles     Next Articles

Role of the autonomic nervous system in immune imbalance in atopic dermatitis

Yu Su, Yu Tianze, Li Wei   

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2021-04-18 Revised:2021-06-29 Online:2022-04-15 Published:2022-04-01
  • Contact: Li Wei E-mail:liweiderma@163.com
  • Supported by:
    National Natural Science Foundation of China(81972939)

Abstract: 【Abstract】 The skin is rich in nerve terminals, among which autonomic nerves closely interacted with keratinocytes and immune cells. The autonomic nerves are critical to skin physiological function. Patients with atopic dermatitis exhibit reduced autonomic innervation, accompanied by autonomic nerve dysfunction such as sweating disorder. Restoration of autonomic neurological function can ameliorate atopic dermatitis. This review summarizes the anatomy and physiological function of skin autonomic nerves, autonomic neurological abnormalities in atopic dermatitis, and possible therapeutic strategies.

Key words: Dermatitis, atopic, Autonomic nervous system, Neuroimmunomodulation, Barrier immunity