Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (11): 1074-1078.doi: 10.35541/cjd.20210158

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Clinical progress in pediatric melanoma

Cao Meng, Hong Anlan, Wang Yan, Fang Fang   

  1. Department of Dermatologic Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2021-02-24 Revised:2021-07-27 Online:2023-11-15 Published:2023-11-03
  • Contact: Wang Yan
  • Supported by:
    National Natural Science Foundation of China(81872216)

Abstract: 【Abstract】 Pediatric melanoma occurs rarely, and the pathogenesis is different in different subtypes. The diagnostic criteria for adult melanoma may not be fully applicable to pediatric patients due to atypical clinical manifestations of some tumors. Surgery is the first?line treatment, and the accurate resection margin could be smaller than that in adults. In recent years, immunotherapy and targeted therapy for melanoma have developed rapidly, but very few drugs have been approved for children. Although there have been few large?sample studies on the treatment of pediatric melanoma, the application of related drugs has been reported in literature. This review summarizes progress in the pathogenesis, clinical manifestations and treatment of pediatric melanoma, in order to provide a reference for the diagnosis and treatment of pediatric melanoma.

Key words: Child, Nevi and melanomas, Molecular targeted therapy, Spitzoid melanoma, Immune checkpoint inhibitors