Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (9): 878-881.doi: 10.35541/cjd.20210023

• Reviews • Previous Articles     Next Articles

Cell metabolism and metastasis of cutaneous malignant melanoma

Dong Dong, Liu Tianyi   

  1. Department of Plastic Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China
  • Received:2021-01-08 Revised:2021-12-08 Online:2023-09-15 Published:2023-09-07
  • Contact: Liu Tianyi
  • Supported by:
    Scientific Research Project of Shanghai Science and Technology Committee (19411962300); Scientific Research Project of Shanghai Municipal Health Commission (201940400)

Abstract: 【Abstract】 In recent years, more and more attention has been paid to the role of metabolism in its invasion and metastasis of cutaneous malignant melanoma (CMM). The plasticity of metabolism and transformation of the metabolic pattern can provide sufficient energy for the metastasis of CMM, and increase its invasiveness and adaptability to different environments. Besides, the interaction between CMM metabolism and tumor microenvironment also plays an important role in the progression of CMM. This review summarizes the latest progress in cell metabolism in the invasion and metastasis of CMM, and its interaction with tumor microenvironment, in order to provide new ideas for the research on mechanisms of CMM metastasis, as well as clinical targeted therapy and immunotherapy.

Key words: Nevi and melanomas, Metabolic networks and pathways, Tumor microenvironment, Neoplasm metastasis