Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (10): 977-981.doi: 10.35541/cjd.20210191

• Reviews • Previous Articles     Next Articles

Application of single-cell RNA sequencing in melanoma research

Li Tingting, Guan Mengmeng, Zhao Juan, Kang Xiaojing   

  1. Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatologic Diseases, Xinjiang Key Laboratory of Dermatology Research (XJYS1707), Urumqi 830001, China
  • Received:2021-03-04 Revised:2022-03-14 Online:2023-10-15 Published:2023-10-08
  • Contact: Kang Xiaojing
  • Supported by:
    Autonomous Region Innovation Environment (Talent, Base) Construction Project “Tianshan Innovation Team Plan” (2020D14006); Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (2021D01C201)

Abstract: 【Abstract】 Tumor heterogeneity is one of the important characteristics of melanoma. Single-cell RNA sequencing can not only further reveal the heterogeneity of melanoma cells, but also has unique advantages in analyzing the occurrence and development of melanoma, finding new targets for immunotherapy and uncovering mechanisms of drug resistance. This review summarizes the application of single-cell transcriptome sequencing in melanoma research.

Key words: Melanoma, Sequence analysis, RNA, Transcriptome, Single-cell analysis, Genetic heterogeneity, Tumor microenvironment, Immunotherapy, Drug resistance, neoplasm, Single-cell RNA sequencing