瞬时受体电位通道在黑素细胞中的作用及相关疾病研究

doi:10.35541/cjd.20200958

Abstract

Abstract: 【Abstract】 Transient receptor potential (TRP) channels are a special type of non-selective cationic channel family located on the cell membrane or organelle membrane, and notably expressed in melanocytes. This review summarizes recent research progress in biological functions of TRP channels in melanocytes and their involvement in the pathological process of pigmented skin diseases and melanoma, so as to provide a new theoretical basis for the prevention and treatment of melanin-related diseases.

Key words: Transient receptor potential channels, Melanocyte, Vitiligo, Melanosis, Melanoma

Chen Yi, Song Xiuzu. Role of transient receptor potential channels in melanocytes and their related diseases[J]. Chinese Journal of Dermatology, 2023, 56(4): 376-379.doi:10.35541/cjd.20200958

References ［28］

［1］	Cosens DJ, Manning A. Abnormal electroretinogram from a Drosophila mutant［J］. Nature, 1969,224（5216）:285⁃287. doi: 10.1038/224285a0.
［2］	Duitama M, Vargas⁃López V, Casas Z, et al. TRP channels role in pain associated with neurodegenerative diseases［J］. Front Neurosci, 2020,14:782. doi: 10.3389/fnins.2020.00782.
［3］	Caterina MJ, Pang Z. TRP Channels in skin biology and pathophysiology［J］. Pharmaceuticals （Basel）, 2016,9（4）:77. doi: 10.3390/ph9040077.
［4］	Peng G, Shi X, Kadowaki T. Evolution of TRP channels inferred by their classification in diverse animal species［J］. Mol Phylogenet Evol, 2015,84:145⁃157. doi: 10.1016/j.ympev.2014. 06.016.
［5］	Xie B, Li XY. Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1［J］. J Dermatol, 2019,46（3）:177⁃185. doi: 10.1111/1346⁃8138.14749.
［6］	Tsvetkov EA, Potatieva NN, Bolshakov KV. Voltage⁃dependent interaction of capsaicine and protons on TRPV1⁃receptors［J］. Acta Naturae, 2017,9（1）:75⁃80.
［7］	Xu L, Han Y, Chen X, et al. Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel［J］. Nat Commun, 2020,11（1）:3790. doi: 10.1038/s41467⁃020⁃17582⁃x.
［8］	Kinoshita J, Iwata N, Ohba M, et al. Mechanism of voriconazole⁃induced transient visual disturbance: reversible dysfunction of retinal ON⁃bipolar cells in monkeys［J］. Invest Ophthalmol Vis Sci, 2011,52（8）:5058⁃5063. doi: 10.1167/iovs.11⁃7183.
［9］	Kang P, Zhang W, Chen X, et al. TRPM2 mediates mitochondria⁃dependent apoptosis of melanocytes under oxidative stress［J］. Free Radic Biol Med, 2018,126:259⁃268. doi: 10.1016/j.freeradbiomed.2018.08.022.
［10］	Bellono NW, Najera JA, Oancea E. UV light activates a Gαq/11⁃coupled phototransduction pathway in human melanocytes［J］. J Gen Physiol, 2014,143（2）:203⁃214. doi: 10.1085/jgp.201311094.
［11］	Bellono NW, Kammel LG, Zimmerman AL, et al. UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes［J］. Proc Natl Acad Sci U S A, 2013,110（6）:2383⁃2388. doi: 10.1073/pnas.1215555110.
［12］	Hu QM, Yi WJ, Su MY, et al. Induction of retinal⁃dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer.［J］. Cell Prolif,2017,50（6）:e12372. DOI: 10.1111/cpr.12372.
［13］	Bellone RR, Brooks SA, Sandmeyer L, et al. Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns （LP） in the Appaloosa horse （Equus caballus）［J］. Genetics, 2008,179（4）:1861⁃1870. doi: 10.1534/genetics.108.088807.
［14］	Xu H, Delling M, Li L, et al. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint⁃waddler mice［J］. Proc Natl Acad Sci U S A, 2007,104（46）:18321⁃18326. doi: 10.1073/pnas.0709096104.
［15］	Decker AR, McNeill MS, Lambert AM, et al. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern［J］. Dev Biol, 2014,386（2）:428⁃439. doi: 10.1016/j.ydbio.2013.11.015.
［16］	Wang X, Li S, Liu L, et al. Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes［J］. J Dermatol Sci, 2019,96（1）:33⁃41. doi: 10.1016/j.jdermsci.2019.09.001.
［17］	Sumoza⁃Toledo A, Penner R. TRPM2: a multifunctional ion channel for calcium signalling［J］. J Physiol, 2011,589（Pt 7）:1515⁃1525. doi: 10.1113/jphysiol.2010.201855.
［18］	Sitohang I, Prayogo RL, Rihatmadja R, et al. The diagnostic conundrum of Riehl melanosis and other facial pigmentary disorders: a case report with overlapping clinical, dermoscopic, and histopathological features［J］. Acta Dermatovenerol Alp Pannonica Adriat, 2020,29（2）:81⁃83.
［19］	Moon IJ, Bang SH, Song Y, et al. Transient receptor potential vanilloid 1 （TRPV1） inhibition is related to the suppression of inflammation⁃associated hypermelanosis［J］. J Dermatol Sci, 2020,98（1）:65⁃68. doi: 10.1016/j.jdermsci.2020.02.008.
［20］	Hantute⁃Ghesquier A, Haustrate A, Prevarskaya N, et al. TRPM family channels in cancer［J］. Pharmaceuticals （Basel）, 2018,11（2）:58. DOI: 10.3390/ph11020058.
［21］	Al⁃Hujaili H, Taskintuna I, Neuhaus C, et al. Long⁃term follow⁃up of retinal function and structure in TRPM1⁃associated complete congenital stationary night blindness［J］. Mol Vis, 2019,25:851⁃858.
［22］	Duvoisin RM, Ren G, Haley TL, et al. TRPM1 autoantibodies in melanoma patients without self⁃reported visual symptoms［J］. Invest Ophthalmol Vis Sci, 2019,60（6）:2330⁃2335. doi: 10.1167/ iovs.19⁃26775.
［23］	Guo H, Carlson JA, Slominski A. Role of TRPM in melanocytes and melanoma［J］. Exp Dermatol, 2012,21（9）:650⁃654. doi: 10. 1111/j.1600⁃0625.2012.01565.x.
［24］	Yang Y, Guo W, Ma J, et al. Downregulated TRPV1 expression contributes to melanoma growth via the calcineurin⁃ATF3⁃p53 pathway.［J］. J Invest Dermatol,2018,138（10）:2205⁃2215. doi: 10.1016/j.jid.2018.03.1510.
［25］	Zheng J, Liu F, Du S, et al. Mechanism for regulation of melanoma cell death via activation of thermo⁃TRPV4 and TRPV2［J］. J Oncol,2019,2019:7362875. doi: 10.1155/2019/7362875.
［26］	Chung H, Jung H, Jho EH, et al. Keratinocytes negatively regulate the N⁃cadherin levels of melanoma cells via contact⁃mediated calcium regulation［J］. Biochem Biophys Res Commun, 2018,503（2）:615⁃620. doi: 10.1016/j.bbrc.2018.06.050.
［27］	Oda K, Umemura M, Nakakaji R, et al. Transient receptor potential cation 3 channel regulates melanoma proliferation and migration［J］. J Physiol Sci, 2017,67（4）:497⁃505. doi: 10.1007/s12576⁃016⁃0480⁃1.
［28］	Gao J, Zeng K, Liu Y, et al. LncRNA SNHG5 promotes growth and invasion in melanoma by regulating the miR⁃26a⁃5p/TRPC3 pathway［J］. Onco Targets Ther, 2019,12:169⁃179. doi: 10.2147/OTT.S184078.

[1]	Zhang Congcong, Chen Hao. Spitzoid melanocytic tumors [J]. Chinese Journal of Dermatology, 2023, 56(5): 463-467.
[2]	Jia Weixue, Li Chengrang. Comparison of Chinese and international guidelines and consensus for the diagnosis and treatment of vitiligo [J]. Chinese Journal of Dermatology, 2023, 56(5): 471-475.
[3]	Li Jiaqi, Ye Feng, Ju Qiang. Symbiotic homeostasis of Staphylococcus epidermidis is associated with common skin disorders [J]. Chinese Journal of Dermatology, 2023, 56(5): 459-462.
[4]	Dai Leheng, Hu Wen, Zhang Kunjie, Kang Xiaojing. Protective effects of isorhamnetin against H2O2-induced mitochondrial structural and functional damage in HaCaT cells [J]. Chinese Journal of Dermatology, 2023, 0(3): 20220821-e20220821.
[5]	Yang Yongting, Li Tingting, Kang Xiaojing. Biomarkers related to the treatment of melanoma with immune checkpoint inhibitors [J]. Chinese Journal of Dermatology, 2023, 56(3): 278-283.
[6]	Wang Yuanli, Liu Ling, Sun Zhongbin, Li Kai. Analysis of 141 cases clinically misdiagnosed as melanoma [J]. Chinese Journal of Dermatology, 2023, 56(3): 244-246.
[7]	Li Tingting, Kang Xiaojing. Gut microbiota and immune checkpoint inhibitor treatment of melanoma [J]. Chinese Journal of Dermatology, 2023, 56(2): 177-180.
[8]	Li Fang, Wang Xiaoqing, Liu Mengxi, Jiang Jiayi, Huang Shudai, Wang Daguang. Research advances in recurrent melanocytic nevus [J]. Chinese Journal of Dermatology, 2023, 0(2): 20220431-e20220431.
[9]	Zhan Jinshan, Xuan Xiuyun, Cao Juanmei, Chen Fangqi, Huang Changzheng. Progress in treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis [J]. Chinese Journal of Dermatology, 2023, 0(2): 20220368-e20220368.
[10]	Zheng Nana, Zeng Rong, Tao Yingkai, Li Min, . Relationship between circular RNAs and skin tumors [J]. Chinese Journal of Dermatology, 2023, 0(2): 20210893-e20210893.
[11]	Li Fang, Chen Wei, Huang Feiran, Zhang Xiaoyu, Zhou Yuan, Liu Zhenru, Wang Daguang. Role of different melanocyte populations in the reconstitution of pigmented hair follicles [J]. Chinese Journal of Dermatology, 2023, 56(2): 118-124.
[12]	Yang Hedan, Ding Hui, Fang Fumin, Zheng Huiying, Zhang Xiaoli, Liu Xing, Ge Yiping, Yang Yin, Lin Tong. Effect of miRNA-193b-5p-mediated decreased expression of transcriptional regulator CITED2 on melanogenesis [J]. Chinese Journal of Dermatology, 2023, 56(1): 29-34.
[13]	Lei Jiehao, Hong Weisong, Lin Fuquan, Hu Wenting, Xu Ai′e. In vitro culture of melanocytes from segmental vitiligo-like nevus depigmentosus lesions and its clinical significance [J]. Chinese Journal of Dermatology, 2022, 55(9): 798-802.
[14]	Jia Weixue, Wang Jianbo, Luo Lingling, Zhang Yuanyuan, Wang Xue, Guo Youming, Kong Lingzhuo, Jiang Yiqun, Li Chengrang, . Effect of HaCaT cells with CRISPR-Cas9-induced KRT5 mutation on co-cultured human melanocytes [J]. Chinese Journal of Dermatology, 2022, 55(8): 659-664.
[15]	Li Baizhang, Kang Pan, Zhang Xiaoying, Zhu Guannan, Li Shuli, Li Chunying. Construction and validation of a risk prediction model for diabetes mellitus in patients with vitiligo [J]. Chinese Journal of Dermatology, 2022, 55(7): 576-582.

Role of transient receptor potential channels in melanocytes and their related diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［28］

Related Articles 15

Metrics

Comments

Recommended 10