Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (4): 376-379.doi: 10.35541/cjd.20200958

• Reviews • Previous Articles    

Role of transient receptor potential channels in melanocytes and their related diseases

Chen Yi1, Song Xiuzu2   

  1. 1Department of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China; 2Department of Dermatology, Hangzhou Third People′s Hospital, Hangzhou 310009, China
  • Received:2020-09-29 Revised:2021-06-16 Online:2023-04-15 Published:2023-03-31
  • Contact: Song XiuZu
  • Supported by:
    National Natural Science Foundation of China (81872517); Zhejiang Basic Public Welfare Research Project (LGF18H110001)

Abstract: 【Abstract】 Transient receptor potential (TRP) channels are a special type of non-selective cationic channel family located on the cell membrane or organelle membrane, and notably expressed in melanocytes. This review summarizes recent research progress in biological functions of TRP channels in melanocytes and their involvement in the pathological process of pigmented skin diseases and melanoma, so as to provide a new theoretical basis for the prevention and treatment of melanin-related diseases.

Key words: Transient receptor potential channels, Melanocyte, Vitiligo, Melanosis, Melanoma