m6A RNA甲基化与皮肤黑素瘤相关性的研究进展

doi:10.35541/cjd.20210064

Abstract

Abstract: 【Abstract】 N6-methyladenosine （m6A） modification can regulate gene expression by influencing RNA stability, nuclear transport, translation efficiency, alternative splicing and degradation. Current studies have shown that m6A modification is associated with multiple biological behaviors of melanoma, such as proliferation, metastasis and resistance to immunotherapy, but specific mechanisms still need further study. This review summarizes the regulation of m6A RNA methylation, and its related biological behaviors and mechanisms of action in melanoma.

Key words: Melanoma, RNA methylation, m6A

Chen Fangqi, Liang Yan, Wu Ting, Huang Changzheng. Associations between m6A RNA methylation and cutaneous melanoma[J]. Chinese Journal of Dermatology, 2023, 56(9): 889-892.doi:10.35541/cjd.20210064

References ［33］

［1］	Garcias Morales D, Reyes JL. A birds′⁃eye view of the activity and specificity of the mRNA m6A methyltransferase complex［J/OL］. Wiley Interdiscip Rev RNA, 2021,12（1）:e1618. doi: 10. 1002/wrna.1618.
［2］	Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation［J］. Nat Rev Mol Cell Biol, 2019,20（10）:608⁃624. doi: 10.1038/s41580⁃019⁃0168⁃5.
［3］	Huang W, Chen TQ, Fang K, et al. N6⁃methyladenosine methyltransferases: functions, regulation, and clinical potential［J］. J Hematol Oncol, 2021,14（1）:117. doi: 10.1186/s13045⁃021⁃01129⁃8.
［4］	Ping XL, Sun BF, Wang L, et al. Mammalian WTAP is a regulatory subunit of the RNA N6⁃methyladenosine methyltransferase［J］. Cell Res, 2014,24（2）:177⁃189. doi: 10.1038/cr.2014.3.
［5］	Yue Y, Liu J, Cui X, et al. VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation［J］. Cell Discov, 2018,4:10. doi: 10.1038/s41421⁃018⁃0019⁃0.
［6］	Patil DP, Chen CK, Pickering BF, et al. m6A RNA methylation promotes XIST⁃mediated transcriptional repression［J］. Nature, 2016,537（7620）:369⁃373. doi: 10.1038/nature19342.
［7］	Knuckles P, Lence T, Haussmann IU, et al. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA⁃binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl（2）d［J］. Genes Dev, 2018,32（5⁃6）:415⁃429. doi: 10. 1101/gad.309146.117.
［8］	Bawankar P, Lence T, Paolantoni C, et al. Hakai is required for stabilization of core components of the m6A mRNA methylation machinery［J］. Nat Commun, 2021,12（1）:3778. doi: 10.1038/s41467⁃021⁃23892⁃5.
［9］	Zhao X, Yang Y, Sun BF, et al. FTO⁃dependent demethylation of N6⁃methyladenosine regulates mRNA splicing and is required for adipogenesis［J］. Cell Res, 2014,24（12）:1403⁃1419. doi: 10. 1038/cr.2014.151.
［10］	Tang C, Klukovich R, Peng H, et al. ALKBH5⁃dependent m6A demethylation controls splicing and stability of long 3′⁃UTR mRNAs in male germ cells［J/OL］. Proc Natl Acad Sci U S A, 2018,115（2）:E325⁃E333. doi: 10.1073/pnas.1717794115.
［11］	Roundtree IA, He C. Nuclear m6A reader YTHDC1 regulates mRNA splicing［J］. Trends Genet, 2016,32（6）:320⁃321. doi: 10. 1016/j.tig.2016.03.006.
［12］	Roundtree IA, Luo GZ, Zhang Z, et al. YTHDC1 mediates nuclear export of N6⁃methyladenosine methylated mRNAs［J/OL］. Elife, 2017,6:e31311. doi: 10.7554/eLife.31311.
［13］	Hsu PJ, Zhu Y, Ma H, et al. Ythdc2 is an N6⁃methyladenosine binding protein that regulates mammalian spermatogenesis［J］. Cell Res, 2017,27（9）:1115⁃1127. doi: 10.1038/cr.2017.99.
［14］	Shi H, Wang X, Lu Z, et al. YTHDF3 facilitates translation and decay of N6⁃methyladenosine⁃modified RNA［J］. Cell Res, 2017,27（3）:315⁃328. doi: 10.1038/cr.2017.15.
［15］	Dai XY, Shi L, Li Z, et al. Main N6⁃methyladenosine readers: YTH family proteins in cancers［J］. Front Oncol, 2021,11:635329. doi: 10.3389/fonc.2021.635329.
［16］	Huang H, Weng H, Sun W, et al. Recognition of RNA N6⁃methyladenosine by IGF2BP proteins enhances mRNA stability and translation［J］. Nat Cell Biol, 2018,20（3）:285⁃295. doi: 10.1038/s41556⁃018⁃0045⁃z.
［17］	Geuens T, Bouhy D, Timmerman V. The hnRNP family: insights into their role in health and disease［J］. Hum Genet, 2016,135（8）:851⁃867. doi: 10.1007/s00439⁃016⁃1683⁃5.
［18］	Valášek LS, Zeman J, Wagner S, et al. Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle［J］. Nucleic Acids Res, 2017,45（19）:10948⁃10968. doi: 10.1093/nar/gkx805.
［19］	Gao R, Ye M, Liu B, et al. m6A modification: a double⁃edged sword in tumor development［J］. Front Oncol, 2021,11:679367. doi: 10.3389/fonc.2021.679367.
［20］	Gide TN, Wilmott JS, Scolyer RA, et al. Primary and acquired resistance to immune checkpoint inhibitors in metastatic melanoma［J］. Clin Cancer Res, 2018,24（6）:1260⁃1270. doi: 10. 1158/1078⁃0432.CCR⁃17⁃2267.
［21］	Lin Y, Wang S, Liu S, et al. Identification and verification of molecular subtypes with enhanced immune infiltration based on m6A regulators in cutaneous melanoma［J］. Biomed Res Int, 2021,2021:2769689. doi: 10.1155/2021/2769689.
［22］	Iles MM, Law MH, Stacey SN, et al. A variant in FTO shows association with melanoma risk not due to BMI［J］. Nat Genet, 2013,45（4）:428⁃432. doi: 10.1038/ng.2571.
［23］	Yang S, Wei J, Cui YH, et al. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti⁃PD⁃1 blockade［J］. Nat Commun, 2019,10（1）:2782. doi: 10.1038/s41467⁃019⁃10669⁃0.
［24］	Dahal U, Le K, Gupta M. RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2［J］. Melanoma Res, 2019,29（4）:382⁃389. doi: 10.1097/CMR.0000000000000580.
［25］	Luo G, Xu W, Zhao Y, et al. RNA m6A methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c⁃Met［J］. J Cell Physiol, 2020,235（10）:7107⁃7119. doi: 10.1002/jcp.29608.
［26］	Kim T, Havighurst T, Kim K, et al. Targeting insulin⁃like growth factor 2 mRNA⁃binding protein 1 （IGF2BP1） in metastatic melanoma to increase efficacy of BRAFV600E inhibitors［J］. Mol Carcinog, 2018,57（5）:678⁃683. doi: 10.1002/mc.22786.
［27］	Karras P, Riveiro⁃Falkenbach E, Cañón E, et al. p62/SQSTM1 fuels melanoma progression by opposing mRNA decay of a selective set of pro⁃metastatic factors［J］. Cancer Cell, 2019,35（1）:46⁃63.e10. doi: 10.1016/j.ccell.2018.11.008.
［28］	Ghoshal A, Rodrigues LC, Gowda CP, et al. Extracellular vesicle⁃dependent effect of RNA⁃binding protein IGF2BP1 on melanoma metastasis［J］. Oncogene, 2019,38（21）:4182⁃4196. doi: 10.1038/s41388⁃019⁃0797⁃3.
［29］	Hanniford D, Ulloa⁃Morales A, Karz A, et al. Epigenetic silencing of CDR1as drives IGF2BP3⁃mediated melanoma invasion and metastasis［J］. Cancer Cell, 2020,37（1）:55⁃70.e15. doi: 10.1016/j.ccell.2019.12.007.
［30］	Chu M, Wan H, Zhang X. Requirement of splicing factor hnRNP A2B1 for tumorigenesis of melanoma stem cells［J］. Stem Cell Res Ther, 2021,12（1）:90. doi: 10.1186/s13287⁃020⁃02124⁃5.
［31］	Li T, Gu M, Deng A, et al. Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis［J］. Cancer Cell Int, 2020,20:239. doi: 10.1186/s12935⁃020⁃01309⁃5.
［32］	Li N, Kang Y, Wang L, et al. ALKBH5 regulates anti⁃PD⁃1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment［J］. Proc Natl Acad Sci U S A, 2020,117（33）:20159⁃20170. doi: 10.1073/pnas.1918 986117.
［33］	Jia R, Chai P, Wang S, et al. m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation［J］. Mol Cancer, 2019,18（1）:161. doi: 10.1186/s12943⁃019⁃1088⁃x.

[1]	Dong Dong, Liu Tianyi. Cell metabolism and metastasis of cutaneous malignant melanoma [J]. Chinese Journal of Dermatology, 2023, 56(9): 878-881.
[2]	Yuan Xingang, Ni Sili, Zhang Jian, Luo Xiaoyan, Wang Hua. Improving diagnosis and treatment of melanocytic nevi in children: an urgent need [J]. Chinese Journal of Dermatology, 2023, 56(8): 782-786.
[3]	Li Jiaqi, Ye Feng, Ju Qiang. Symbiotic homeostasis of Staphylococcus epidermidis is associated with common skin disorders [J]. Chinese Journal of Dermatology, 2023, 56(5): 459-462.
[4]	Zhang Congcong, Chen Hao. Spitzoid melanocytic tumors [J]. Chinese Journal of Dermatology, 2023, 56(5): 463-467.
[5]	Chen Yi, Song Xiuzu. Role of transient receptor potential channels in melanocytes and their related diseases [J]. Chinese Journal of Dermatology, 2023, 56(4): 376-379.
[6]	Yang Yongting, Li Tingting, Kang Xiaojing. Biomarkers related to the treatment of melanoma with immune checkpoint inhibitors [J]. Chinese Journal of Dermatology, 2023, 56(3): 278-283.
[7]	Wang Yuanli, Liu Ling, Sun Zhongbin, Li Kai. Analysis of 141 cases clinically misdiagnosed as melanoma [J]. Chinese Journal of Dermatology, 2023, 56(3): 244-246.
[8]	Zhang Fuhe, Shi Lei, Luo Min, Liu Pei, Fan Qing, Wang Xiuli. Establishment of a SKH-1 mouse model of transplanted B16F10 melanoma [J]. Chinese Journal of Dermatology, 2023, 0(3): 20210689-e20210689.
[9]	Zheng Nana, Zeng Rong, Tao Yingkai, Li Min, . Relationship between circular RNAs and skin tumors [J]. Chinese Journal of Dermatology, 2023, 0(2): 20210893-e20210893.
[10]	Li Fang, Wang Xiaoqing, Liu Mengxi, Jiang Jiayi, Huang Shudai, Wang Daguang. Research advances in recurrent melanocytic nevus [J]. Chinese Journal of Dermatology, 2023, 0(2): 20220431-e20220431.
[11]	Zhan Jinshan, Xuan Xiuyun, Cao Juanmei, Chen Fangqi, Huang Changzheng. Progress in treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis [J]. Chinese Journal of Dermatology, 2023, 0(2): 20220368-e20220368.
[12]	Li Tingting, Kang Xiaojing. Gut microbiota and immune checkpoint inhibitor treatment of melanoma [J]. Chinese Journal of Dermatology, 2023, 56(2): 177-180.
[13]	Yang Hedan, Ding Hui, Fang Fumin, Zheng Huiying, Zhang Xiaoli, Liu Xing, Ge Yiping, Yang Yin, Lin Tong. Effect of miRNA-193b-5p-mediated decreased expression of transcriptional regulator CITED2 on melanogenesis [J]. Chinese Journal of Dermatology, 2023, 56(1): 29-34.
[14]	Xia Li, Yang Linhong, Xu Li, Sun Wenguo, Yu Liang, Zhai Wanfang, Wang Dongxia, Kuang Xiaowan. Effect of microRNA-181b-5p on the proliferation and invasion of cutaneous melanoma cells and its mechanisms [J]. Chinese Journal of Dermatology, 2022, 55(7): 588-595.
[15]	Zhang Ning, Li Shu, Li Jing . Efficacy of immune checkpoint inhibitors and targeted therapy in adjuvant treatment of resectable melanoma: a network meta-analysis [J]. Chinese Journal of Dermatology, 2022, 55(7): 603-609.

Associations between m6A RNA methylation and cutaneous melanoma

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［33］

Related Articles 15

Metrics

Comments

Recommended 10