Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (9): 889-892.doi: 10.35541/cjd.20210064

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Associations between m6A RNA methylation and cutaneous melanoma

Chen Fangqi, Liang Yan, Wu Ting, Huang Changzheng   

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2021-01-21 Revised:2021-09-25 Online:2023-09-15 Published:2023-09-07
  • Contact: Huang Changzheng
  • Supported by:
    National Natural Science Foundation of China(81972565)

Abstract: 【Abstract】 N6-methyladenosine (m6A) modification can regulate gene expression by influencing RNA stability, nuclear transport, translation efficiency, alternative splicing and degradation. Current studies have shown that m6A modification is associated with multiple biological behaviors of melanoma, such as proliferation, metastasis and resistance to immunotherapy, but specific mechanisms still need further study. This review summarizes the regulation of m6A RNA methylation, and its related biological behaviors and mechanisms of action in melanoma.

Key words: Melanoma, RNA methylation, m6A