微生物群体感应系统在皮肤炎症发展中的作用机制

doi:10.35541/cjd.20200902

Abstract

Abstract: 【Abstract】 Quorum-sensing system is a way of communication between cells that depends on changes in population density of microorganisms, and is closely associated with variety and pathogenicity of skin microbiota. The synthesis of virulence factors of Staphylococcus aureus （S. aureus） is regulated by the accessory gene regulator （Agr） quorum-sensing system. Various skin commensals such as coagulase-negative Staphylococcus and Corynebacterium can inhibit the Agr quorum-sensing system of S. aureus, thus decrease the synthesis of virulence factors and attenuate skin inflammation. This review summarizes the mechanism of action of microbial quorum-sensing system in skin inflammation and various quorum-sensing inhibitors.

Key words: Quorum sensing, Microbial consortia, Dermatitis, atopic, Staphylococcus aureus, Quorum quenching

Zhou Yuan, Yao Xu. Mechanism of action of the microbial quorum-sensing system in the development of skin inflammation[J]. Chinese Journal of Dermatology, 2023, 56(4): 372-375.doi:10.35541/cjd.20200902

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Mechanism of action of the microbial quorum-sensing system in the development of skin inflammation

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