Counteractive effect of mouse dermal fibroblasts during their adipogenic differentiation against Staphylococcus aureus infection and its mechanisms
Liu Weizhao1, Duan Zhimin2, Wang Jianing2, Li Min1,2, Chen Xu1,2
1Nanjing Medical University, Nanjing 211166, China; 2Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
National Natural Science Foundation of China (82173432, 82103749); CAMS Innovation Fund for Medical Sciences (2017-I2M-1-017, 2021-I2M-1-059); Natural Science Foundation of Jiangsu Province (BK20190144); The Nanjing Incubation Program for National Clinical Research Center (2019060001)
Liu Weizhao, Duan Zhimin, Wang Jianing, Li Min, Chen Xu, . Counteractive effect of mouse dermal fibroblasts during their adipogenic differentiation against Staphylococcus aureus infection and its mechanisms[J]. Chinese Journal of Dermatology, 2023, 56(7): 630-635.doi:10.35541/cjd.20220528
Lakhundi S, Zhang K. Methicillin⁃resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology[J]. Clin Microbiol Rev, 2018,31(4):e00020⁃18. doi: 10.1128/CMR.00020⁃18.
[2]
Kourtis AP, Hatfield K, Baggs J, et al. Vital signs: epidemiology and recent trends in methicillin⁃resistant and in methicillin⁃susceptible Staphylococcus aureus bloodstream infections⁃ United States[J]. MMWR Morb Mortal Wkly Rep, 2019,68(9):214⁃219. doi: 10.15585/mmwr.mm6809e1.
[3]
Grant RW, Dixit VD. Adipose tissue as an immunological organ[J]. Obesity (Silver Spring), 2015,23(3):512⁃518. doi: 10.1002/ oby.21003.
[4]
Zhang LJ, Guerrero⁃Juarez CF, Hata T, et al. Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection[J]. Science, 2015,347(6217):67⁃71. doi: 10.1126/science.1260972.
[5]
Schmid A, Karrasch T, Thomalla M, et al. Innate immunity of adipose tissue in rodent models of local and systemic Staphylococcus aureus infection[J]. Mediators Inflamm, 2017,2017:5315602. doi: 10.1155/2017/5315602.
[6]
Pond CM, Mattacks CA. In vivo evidence for the involvement of the adipose tissue surrounding lymph nodes in immune responses[J]. Immunol Lett, 1998,63(3):159⁃167. doi: 10.1016/s0165⁃2478(98)00074⁃1.
[7]
Macdougall CE, Wood EG, Loschko J, et al. Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets[J]. Cell Metab, 2018,27(3):588⁃601.e4. doi: 10.1016/j.cmet.2018.02.00.
Flaherty SE 3rd, Grijalva A, Xu X, et al. A lipase⁃independent pathway of lipid release and immune modulation by adipocytes[J]. Science, 2019,363(6430):989⁃993. doi: 10.1126/science.aaw2586.
[10]
Zhang LJ, Chen SX, Guerrero⁃Juarez CF, et al. Age⁃related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta[J]. Immunity, 2019,50(1):121⁃136.e5. doi: 10.1016/j.immuni.2018.11.003.
[11]
Gurriarán⁃Rodríguez U, Al⁃Massadi O, Roca⁃Rivada A, et al. Obestatin as a regulator of adipocyte metabolism and adipogenesis[J]. J Cell Mol Med, 2011,15(9):1927⁃1940. doi: 10.1111/j.1582⁃4934.2010.01192.x.
[12]
Styner M, Sen B, Xie Z, et al. Indomethacin promotes adipogenesis of mesenchymal stem cells through a cyclooxygenase independent mechanism[J]. J Cell Biochem, 2010,111(4):1042⁃1050. doi: 10.1002/jcb.22793.