Chinese Journal of Dermatology ›› 2022, e20220135.doi: 10.35541/cjd.20220135

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Ferroptosis in melanoma

Zhang Congcong, Chen Hao   

  1. Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2022-03-02 Revised:2022-08-03 Online:2022-01-01 Published:2022-11-11
  • Contact: Chen Hao
  • Supported by:
    Natural Science Foundation of Jiangsu Province (BK20211026); Medical Research Project of Jiangsu Provincial Health Commission (M2021045); The Nanjing Incubation Program for National Clinical Research Center (2019060001)

Abstract: 【Abstract】 Ferroptosis, a newly discovered form of iron-dependent regulation of cell death, has been found to be associated with the development of various cancers, including melanoma. This review summarizes recent progress in roles of ferroptosis in the pathogenesis, metastasis and treatment of melanoma, aiming to provide a theoretical basis for the development of new drugs and new treatment strategies for melanoma in clinical practice.

Key words: Nevi and melanoma, Cell death, Lipid peroxidation, Ferroptosis

CLC Number: 

  • R751