铁死亡在常见皮肤病中的研究进展

doi:10.35541/cjd.20220783

Abstract

Abstract: 【Abstract】 Ferroptosis is a new type of iron-dependent cell death, primarily caused by decreased bioactivity of glutathione peroxidase 4, lipid peroxidation, and excessive accumulation of reactive oxygen species. It involves intricate regulatory mechanisms, including iron metabolism, lipid metabolism, amino acid metabolism, and the oxidation/antioxidant system. In recent years, studies have shown that ferroptosis is involved in the occurrence and development of several common skin diseases. This review summarizes research progress in the role and mechanisms of action of ferroptosis in common skin diseases, aiming to provide new research directions and ideas for the treatment of skin diseases.

Key words: Cell death, Skin diseases, Ferroptosis, Glutathione peroxidase 4, Vitiligo, Psoriasis, Melanoma, Lupus erythematosus, systemic

Liu Lyuye, Zhang Junling. Ferroptosis in common skin diseases[J]. Chinese Journal of Dermatology, 2026, 59(10): 1012-1016.doi:10.35541/cjd.20220783

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Ferroptosis in common skin diseases

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