Chinese Journal of Dermatology ›› 2025, e20240125.doi: 10.35541/cjd.20240125

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Ferroptosis mechanisms and related intervention measures in malignant skin tumors

Li Jiaming1, Wang Peng2, Kang Xiaojing2   

  1. 1College of Life Science and Technology, Xinjiang University, Urumqi 830001, China; 2Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatology and Venereology, Xinjiang Key Laboratory of Dermatology Research, Urumqi 830000, China
  • Received:2024-03-11 Revised:2024-10-27 Online:2025-01-24 Published:2025-05-26
  • Contact: Kang Xiaojing E-mail:drkangxj666@163.com
  • Supported by:
    Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01D23)

Abstract: 【Abstract】 Ferroptosis is a controllable cell death mechanism that can overcome therapeutic resistance in various tumors, but its research in malignant skin tumors is still limited. This review summarizes the research progress in mechanisms of ferroptosis and related intervention measures in malignant skin tumors, providing references for clinical drug development and treatment.

Key words: Skin neoplasms, Cell death, Skin malignant tumor, Ferroptosis, Ferroptosis?inducing agents, Nanotechnology, Immunotherapy