Chinese Journal of Dermatology ›› 2023, e20230022.doi: 10.35541/cjd.20230022

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Application of multi-photon microscopy in dermatology

Zhang Jiaqi1, Wu Fan1, Han Yuqing1, Liu Qi2, Pan Yao1   

  1. 1Department of Cosmetics, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China; 2Beijing Yiweishi Testing Technology Limited Liability Company, Beijing 100048, China
  • Received:2023-01-13 Revised:2023-06-15 Online:2023-01-05 Published:2023-09-04
  • Contact: Pan Yao

Abstract: 【Abstract】 Multi-photon microscopy has been used for skin tissue imaging based on the principle that endogenous fluorescent components in specific skin tissues or exogenous fluorescence-labeled substances could emit fluorescence under different excitation wavelengths of near-infrared lasers. It is an effective imaging technique for the auxiliary diagnosis of skin neoplasms, inflammatory skin diseases, wound healing and skin aging, with the advantages of in vivo, non-invasive and accurate three-dimensional skin imaging. This review summarizes the application of and progress in multi-photon microscopy in clinical practice in dermatology.

Key words: Skin neoplasms, Skin diseases, Skin aging, Multi-photon microscopy, Skin wound healing