人工合成仿生纳米聚多巴胺黑色素在皮肤科的应用与展望

doi:10.35541/cjd.20220567

Abstract

Abstract: 【Abstract】 Polydopamine is a biomimetic melanin-like nanomaterial, formed through the self-polymerization of dopamine in an alkaline environment. It possesses excellent adhesion properties and biocompatibility. This review summarizes the biological properties of polydopamine and its application in wound healing, skin infections, sun protection and radiation protection, skin tumors, and hypopigmented skin diseases, in order to provide a reference for the application of polydopamine in the treatment of skin diseases.

Key words: Melanins, Dopamine, Polymers, Nanostructures, Biomimetic materials, Skin diseases

Jiang Zhaoting, Jian Zhe. Application and prospect of artificial synthesized biomimetic polydopamine melanin nanoparticles in dermatology [J]. Chinese Journal of Dermatology,2024,e20220567. doi:10.35541/cjd.20220567

References ［24］

［1］	Park J, Moon H, Hong S. Recent advances in melanin⁃like nanomaterials in biomedical applications: a mini review［J］. Biomater Res, 2019,23:24. doi: 10.1186/s40824⁃019⁃0175⁃9.
［2］	Lee H, Dellatore SM, Miller WM, et al. Mussel⁃inspired surface chemistry for multifunctional coatings［J］. Science, 2007,318（5849）:426⁃430. doi: 10.1126/science.1147241.
［3］	Wei Y, Nie Y, Han Z, et al. Au@polydopamine nanoparticles/tocilizumab composite as efficient scavengers of oxygen free radicals for improving the treatment of rheumatoid arthritis［J］. Mater Sci Eng C Mater Biol Appl, 2021,118:111434. doi: 10.1016/j.msec.2020.111434.
［4］	Bao X, Zhao J, Sun J, et al. Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease［J］. ACS Nano, 2018,12（9）:8882⁃8892. doi: 10.1021/acsnano.8b04022.
［5］	Zhang Y, Ren X, Wang Y, et al. Targeting ferroptosis by polydopamine nanoparticles protects heart against ischemia/reperfusion injury［J］. ACS Appl Mater Interfaces, 2021,13（45）:53671⁃53682. doi: 10.1021/acsami.1c18061.
［6］	Lou X, Hu Y, Zhang H, et al. Polydopamine nanoparticles attenuate retina ganglion cell degeneration and restore visual function after optic nerve injury［J］. J Nanobiotechnology, 2021,19（1）:436. doi: 10.1186/s12951⁃021⁃01199⁃3.
［7］	Moreiras H, Pereira F, Neto MV, et al. The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes［J］. Pigment Cell Melanoma Res, 2020,33（2）:366⁃371. doi: 10.1111/pcmr.12840.
［8］	Huang Y, Li Y, Hu Z, et al. Mimicking melanosomes: polydopamine nanoparticles as artificial microparasols［J］. ACS Cent Sci, 2017,3（6）:564⁃569. doi: 10.1021/acscentsci.6b00230.
［9］	Hu J, Yang L, Yang P, et al. Polydopamine free radical scavengers［J］. Biomater Sci, 2020,8（18）:4940⁃4950. doi: 10.1039/d0bm 01070g.
［10］	Zhao H, Zeng Z, Liu L, et al. Polydopamine nanoparticles for the treatment of acute inflammation⁃induced injury［J］. Nanoscale, 2018,10（15）:6981⁃6991. doi: 10.1039/c8nr00838h.
［11］	Zhong G, Yang X, Jiang X, et al. Dopamine⁃melanin nanoparticles scavenge reactive oxygen and nitrogen species and activate autophagy for osteoarthritis therapy［J］. Nanoscale, 2019,11（24）:11605⁃11616. doi: 10.1039/c9nr03060c.
［12］	Liu Y, Ai K, Lu L. Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields［J］. Chem Rev, 2014,114（9）:5057⁃5115. doi: 10.1021/cr400407a.
［13］	Jing Y, Deng Z, Yang X, et al. Ultrathin two⁃dimensional polydopamine nanosheets for multiple free radical scavenging and wound healing［J］. Chem Commun（Camb）, 2020,56（74）:10875⁃10878. doi: 10.1039/d0cc02888f.
［14］	Fu Y, Zhang J, Wang Y, et al. Reduced polydopamine nanoparticles incorporated oxidized dextran/chitosan hybrid hydrogels with enhanced antioxidative and antibacterial properties for accelerated wound healing［J］. Carbohydr Polym, 2021,257:117598. doi: 10.1016/j.carbpol.2020.117598.
［15］	Qin P, Meng Y, Yang Y, et al. Mesoporous polydopamine nanoparticles carrying peptide RL⁃QN15 show potential for skin wound therapy［J］. J Nanobiotechnology, 2021,19（1）:309. doi: 10.1186/s12951⁃021⁃01051⁃8.
［16］	Wang Y, Xiao D, Quan L, et al. Mussel⁃inspired adhesive gelatin⁃polyacrylamide hydrogel wound dressing loaded with tetracycline hydrochloride to enhance complete skin regeneration［J］. Soft Matter, 2022,18（3）:662⁃674. doi: 10.1039/d1sm01373d.
［17］	Xu X, Liu X, Tan L, et al. Controlled⁃temperature photothermal and oxidative bacteria killing and acceleration of wound healing by polydopamine⁃assisted Au⁃hydroxyapatite nanorods［J］. Acta Biomater, 2018,77:352⁃364. doi: 10.1016/j.actbio.2018.07.030.
［18］	Zhou Y, Qian Y, Wang J, et al. Bioinspired lignin⁃polydopamine nanocapsules with strong bioadhesion for long⁃acting and high⁃performance natural sunscreens［J］. Biomacromolecules, 2020,21（8）:3231⁃3241. doi: 10.1021/acs.biomac.0c00696.
［19］	Wang C, Wang D, Dai T, et al. Skin pigmentation⁃inspired polydopamine sunscreens［J］. Advanced Functional Materials, 2018, 28（33）:1802127. doi: 10.1002/adfm.201802127.
［20］	Tang Z, Miao Y, Zhao J, et al. Mussel⁃inspired biocompatible polydopamine/carboxymethyl cellulose/polyacrylic acid adhesive hydrogels with UV⁃shielding capacity［J］. Cellulose（Lond）, 2021,28（3）:1527⁃1540. doi: 10.1007/s10570⁃020⁃03596⁃7.
［21］	Wang X, Zhang J, Wang Y, et al. Multi⁃responsive photothermal⁃chemotherapy with drug⁃loaded melanin⁃like nanoparticles for synergetic tumor ablation［J］. Biomaterials, 2016,81:114⁃124. doi: 10.1016/j.biomaterials.2015.11.037.
［22］	Liu M, Peng Y, Nie Y, et al. Co⁃delivery of doxorubicin and DNAzyme using ZnO@polydopamine core⁃shell nanocomposites for chemo/gene/photothermal therapy［J］. Acta Biomater, 2020,110:242⁃253. doi: 10.1016/j.actbio.2020.04.041.
［23］	Chen W, Qin M, Chen X, et al. Combining photothermal therapy and immunotherapy against melanoma by polydopamine⁃coated Al2O3 nanoparticles［J］. Theranostics, 2018,8（8）:2229⁃2241. doi: 10.7150/thno.24073.
［24］	Sun MC, Xu XL, Du Y, et al. Biomimetic melanosomes promote orientation⁃selective delivery and melanocyte pigmentation in the H2O2⁃induced vitiligo mouse model［J］. ACS Nano, 2021,15（11）:17361⁃17374. doi: 10.1021/acsnano.1c05321.

[1]	Ai Fangting, Sun Zijun, Miao Guoying, Yao Chunxia. Role of calcium-sensing receptors in the pathophysiology of skin of the elderly [J]. Chinese Journal of Dermatology, 2025, 58(1): 76-79.
[2]	Hao Feng, Liu Guoyan. Application of optical coherence tomography in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(9): 853-857.
[3]	Zhang Jiaqi, Wu Fan, Han Yuqing, Liu Qi, Pan Yao. Application of multi-photon microscopy in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(9): 857-862.
[4]	Zou Xianbiao, Chen Jinchun, Zeng Yue, Hao Yi. Application of ultrasonography in dermatology: progress and prospects [J]. Chinese Journal of Dermatology, 2024, 57(9): 785-790.
[5]	Zeng Yue, Shao Huihong, Lin Shiwen, Wen Rou, Zou Xianbiao. Application of a wearable teleconsultation device in diagnosis of common skin diseases [J]. Chinese Journal of Dermatology, 2024, 57(9): 797-800.
[6]	Wang Chen, Xue Chenhong, Song Jinghui, Li Jianguo, Li Zhenlu, Zhang Shoumin, Li Ming, Wang Jianbo. Adalimumab for the treatment of three cases of Blau syndrome in a pedigree [J]. Chinese Journal of Dermatology, 2024, 57(6): 553-556.
[7]	Wang Shan, Jiao Lei, Liu Ying, Zhao Mutong, Shen Chunping, Xiao Yuanyuan, Li Li, Liang Yuan, Tian Jing, Wang Yang, Ma Lin. Protective effects of a sunscreen lotion containing Calendula extracts on children′s skin after sun exposure: a single-center, randomized, parallel controlled clinical study [J]. Chinese Journal of Dermatology, 2024, 57(6): 562-566.
[8]	Jing Ke, Li Suo, Feng Suying. Clinical and immunoserological characteristics of 26 cases of linear IgA bullous dermatosis: a retrospective analysis [J]. Chinese Journal of Dermatology, 2024, 57(6): 503-509.
[9]	Han Yan, Xu Peng, Xiang Zhi, Jiang Tingting, Ge Fengqin, Yin Yueping, Chen Xiangsheng, . Strengthening research on prevention and treatment of chronic skin diseases — population medicine research program [J]. Chinese Journal of Dermatology, 2024, 57(6): 567-569.
[10]	Hong Yongzhen, Wang Qian, Liang Junqin, . Application of next-generation sequencing in the field of non-hereditary dermatoses [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220436-e20220436.
[11]	Han Bing, Wang Hong, Liu Hesong, Li Shanshan. Exploration of the application of apremilast in various inflammatory skin diseases [J]. Chinese Journal of Dermatology, 2024, 0(3): 20240133-e20240133.
[12]	Gao Jinping, Zhang Xuejun, . Clinical application of baricitinib in dermatology [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230528-e20230528.
[13]	Liu Lyuye, Zhang Junling. Ferroptosis in common skin diseases [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220783-e20220783.
[14]	Guo Lei, Cao Chunyan, Fang Xiaoya, Feng Suying. Analysis of current status and risk factors of multidrug-resistant bacteria wound infections in patients with autoimmune bullous diseases [J]. Chinese Journal of Dermatology, 2024, 57(2): 155-160.
[15]	Sun Jiayi, Song Xiuzu. Role of transient receptor potential vanilloid type 4 channel in skin diseases [J]. Chinese Journal of Dermatology, 2024, 57(12): 1149-1152.

Application and prospect of artificial synthesized biomimetic polydopamine melanin nanoparticles in dermatology

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［24］

Related Articles 15

Metrics

Comments

Recommended 10