Chinese Journal of Dermatology ›› 2025, e20240148.doi: 10.35541/cjd.20240148
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Jin Zhe, Gao Dong
Received:
2024-03-21
Revised:
2025-05-08
Online:
2025-01-24
Published:
2025-09-23
Contact:
Gao Dong
E-mail:13385351257@163.com
Jin Zhe, Gao Dong. Application and prospect of exosomes in infection and inflammatory skin diseases[J]. Chinese Journal of Dermatology,2025,e20240148. doi:10.35541/cjd.20240148
[1] | Yáñez⁃Mó M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions[J]. J Extracell Vesicles, 2015,4:27066. doi: 10.3402/jev.v4.27066. |
[2] | Doyle LM, Wang MZ. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis[J]. Cells, 2019,8(7):727. doi: 10.3390/cells 8070727. |
[3] | Liu G, Wu J, Chen G, et al. The potential therapeutic value and application prospect of engineered exosomes in human diseases[J]. Front Cell Dev Biol, 2022,10:1051380. doi: 10.3389/fcell. 2022.1051380. |
[4] | Han M, Yang H, Lu X, et al. Three⁃dimensional⁃cultured MSC⁃derived exosome⁃hydrogel hybrid microneedle array patch for spinal cord repair[J]. Nano Lett, 2022,22(15):6391⁃6401. doi: 10.1021/acs.nanolett.2c02259. |
[5] | Setiadi VE, Adlia A, Barlian A, et al. Development and characterization of a gel formulation containing golden cherry exosomes (Physalis minima) as a potential anti⁃photoaging[J]. Pharm Nanotechnol, 2024,12(1):56⁃67. doi: 10.2174/22117385 11666230509123941. |
[6] | Ma X, Liu B, Fan L, et al. Native and engineered exosomes for inflammatory disease[J]. Nano Res, 2023,16(5):6991⁃7006. doi: 10.1007/s12274⁃022⁃5275⁃5. |
[7] | Banks WA, Sharma P, Bullock KM, et al. Transport of extracellular vesicles across the blood⁃brain barrier: brain pharmacokinetics and effects of inflammation[J]. Int J Mol Sci, 2020,21(12):4407. doi: 10.3390/ijms21124407. |
[8] | Lee BC, Kang I, Yu KR. Therapeutic features and updated clinical trials of mesenchymal stem cell (MSC)⁃derived exosomes[J]. J Clin Med, 2021,10(4):711. doi: 10.3390/jcm 10040711. |
[9] | Ti D, Hao H, Fu X, et al. Mesenchymal stem cells⁃derived exosomal microRNAs contribute to wound inflammation[J]. Sci China Life Sci, 2016,59(12):1305⁃1312. doi: 10.1007/s11427⁃016⁃0240⁃4. |
[10] | He L, Chen Y, Ke Z, et al. Exosomes derived from miRNA⁃210 overexpressing bone marrow mesenchymal stem cells protect lipopolysaccharide induced chondrocytes injury via the NF⁃κB pathway[J]. Gene, 2020,751:144764. doi: 10.1016/j.gene.2020. 144764. |
[11] | Shen K, Jia Y, Wang X, et al. Exosomes from adipose⁃derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO⁃1 axis in macrophages[J]. Free Radic Biol Med, 2021,165:54⁃66. doi: 10.1016/j.freeradbiomed.2021.01.023. |
[12] | Shi Y, Kang X, Wang Y, et al. Exosomes derived from bone marrow stromal cells (BMSCs) enhance tendon⁃bone healing by regulating macrophage polarization[J]. Med Sci Monit, 2020,26:e923328. doi: 10.12659/MSM.923328. |
[13] | Cho BS, Kim JO, Ha DH, et al. Exosomes derived from human adipose tissue⁃derived mesenchymal stem cells alleviate atopic dermatitis[J]. Stem Cell Res Ther, 2018,9(1):187. doi: 10.1186/s13287⁃018⁃0939⁃5. |
[14] | Shin KO, Ha DH, Kim JO, et al. Exosomes from human adipose tissue⁃derived mesenchymal stem cells promote epidermal barrier repair by inducing de novo synthesis of ceramides in atopic dermatitis[J]. Cells, 2020,9(3):680. doi: 10.3390/cells 9030680. |
[15] | Kim MH, Choi SJ, Choi HI, et al. Lactobacillus plantarum⁃derived extracellular vesicles protect atopic dermatitis induced by staphylococcus aureus⁃derived extracellular vesicles[J]. Allergy Asthma Immunol Res, 2018,10(5):516⁃532. doi: 10. 4168/aair.2018.10.5.516. |
[16] | 中华医学会皮肤性病学分会银屑病专业委员会. 中国银屑病诊疗指南(2023版)[J]. 中华皮肤科杂志, 2023,56(7):573⁃625. doi: 10.35541/cjd.20220839. |
[17] | Zhang Y, Yan J, Li Z, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate psoriasis⁃like skin inflammation[J]. J Interferon Cytokine Res, 2022,42(1):8⁃18. doi: 10.1089/jir.2021.0146. |
[18] | Seetharaman R, Mahmood A, Kshatriya P, et al. Mesenchymal stem cell conditioned media ameliorate psoriasis vulgaris: a case study[J]. Case Rep Dermatol Med, 2019,2019:8309103. doi: 10.1155/2019/8309103. |
[19] | Zhang B, Lai RC, Sim WK, et al. Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis⁃like inflammation[J]. Int J Mol Sci, 2021,22(2):720. doi: 10.3390/ijms22020720. |
[20] | Rodrigues SC, Cardoso R, Freire PC, et al. Immunomodulatory properties of umbilical cord blood⁃derived small extracellular vesicles and their therapeutic potential for inflammatory skin disorders[J]. Int J Mol Sci, 2021,22(18):9797. doi: 10.3390/ijms22189797. |
[21] | Golubinskaya PA, Sarycheva MV, Dolzhikov AA, et al. Application of multipotent mesenchymal stem cell secretome in the treatment of adjuvant arthritis and contact⁃allergic dermatitis in animal models[J]. Pharmacy & Pharmacology, 2021, 8:416⁃425. doi: 10.19163/2307⁃9266⁃2020⁃8⁃6⁃416⁃425. |
[22] | Guo L, Lai P, Wang Y, et al. Extracellular vesicles from mesenchymal stem cells prevent contact hypersensitivity through the suppression of Tc1 and Th1 cells and expansion of regulatory T cells[J]. Int Immunopharmacol, 2019,74:105663. doi: 10. 1016/j.intimp.2019.05.048. |
[23] | Bianco NR, Kim SH, Ruffner MA, et al. Therapeutic effect of exosomes from indoleamine 2,3⁃dioxygenase⁃positive dendritic cells in collagen⁃induced arthritis and delayed⁃type hypersensitivity disease models[J]. Arthritis Rheum, 2009,60(2):380⁃389. doi: 10.1002/art.24229. |
[24] | Wang ZC, Zhao WY, Cao Y, et al. The roles of inflammation in keloid and hypertrophic scars[J]. Front Immunol, 2020,11:603187. doi: 10.3389/fimmu.2020.603187. |
[25] | Teng L, Maqsood M, Zhu M, et al. Exosomes derived from human umbilical cord mesenchymal stem cells accelerate diabetic wound healing via promoting m2 macrophage polarization, angiogenesis, and collagen deposition[J]. Int J Mol Sci, 2022,23(18):10421. doi: 10.3390/ijms231810421. |
[26] | Cho KA, Cha JE, Kim J, et al. Mesenchymal stem cell⁃derived exosomes attenuate TLR7⁃mediated mast cell activation[J]. Tissue Eng Regen Med, 2022,19(1):117⁃129. doi: 10.1007/s13770⁃021⁃00395⁃4. |
[27] | Loh JT, Zhang B, Teo J, et al. Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes[J]. Cytotherapy, 2022,24(7):711⁃719. doi: 10.1016/j.jcyt.2021.12. 003. |
[28] | 陶瑞, 谭植襄, 李思成, 等. 外泌体在增生性瘢痕和瘢痕疙瘩治疗中的研究进展[J]. 临床外科杂志, 2022,30(12):1196⁃1199. doi: 10.3969/j.issn.1005⁃6483.2022.12.028. |
[29] | Li Y, Zhang J, Shi J, et al. Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR⁃192⁃5p/IL⁃17RA/Smad axis[J]. Stem Cell Res Ther, 2021,12(1):221. doi: 10.1186/s13287⁃021⁃02290⁃0. |
[30] | Wang L, Hu L, Zhou X, et al. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling[J]. Sci Rep, 2017,7(1):13321. doi: 10.1038/s41598⁃017⁃12919⁃x. |
[31] | Jiang T, Wang Z, Sun J. Human bone marrow mesenchymal stem cell⁃derived exosomes stimulate cutaneous wound healing mediates through TGF⁃β/Smad signaling pathway[J]. Stem Cell Res Ther, 2020,11(1):198. doi: 10.1186/s13287⁃020⁃01723⁃6. |
[32] | Xu XQ, Zhang B, Guo L, et al. Exosomes transport anti⁃human immunodeficiency virus factors from human cervical epithelial cells to macrophages[J]. J Innate Immun, 2021,13(5):269⁃279. doi: 10.1159/000514886. |
[33] | Conzelmann C, Groß R, Zou M, et al. Salivary extracellular vesicles inhibit Zika virus but not SARS⁃CoV⁃2 infection[J]. J Extracell Vesicles, 2020,9(1):1808281. doi: 10.1080/20013078. 2020.1808281. |
[34] | Leng Z, Zhu R, Hou W, et al. Transplantation of ACE2(⁃) mesenchymal stem cells improves the outcome of patients with COVID⁃19 pneumonia[J]. Aging Dis, 2020,11(2):216⁃228. doi: 10.14336/AD.2020.0228. |
[35] | Lin BL, Chen JF, Qiu WH, et al. Allogeneic bone marrow⁃derived mesenchymal stromal cells for hepatitis B virus⁃related acute⁃on⁃chronic liver failure: a randomized controlled trial[J]. Hepatology, 2017,66(1):209⁃219. doi: 10.1002/hep.29189. |
[36] | Brauer VS, Pessoni AM, Bitencourt TA, et al. Extracellular vesicles from aspergillus flavus induce M1 polarization in vitro[J]. mSphere, 2020,5(3):e00190⁃00120. doi: 10.1128/mSphere. 00190⁃20. |
[37] | Bhatnagar S, Shinagawa K, Castellino FJ, et al. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo[J]. Blood, 2007,110(9):3234⁃3244. doi: 10.1182/blood⁃2007⁃03⁃079152. |
[38] | Jia R, Cui K, Li Z, et al. NK cell⁃derived exosomes improved lung injury in mouse model of Pseudomonas aeruginosa lung infection[J]. J Physiol Sci, 2020,70(1):50. doi: 10.1186/s12576⁃020⁃00776⁃9. |
[39] | Kasiri MM, Beer L, Nemec L, et al. Dying blood mononuclear cell secretome exerts antimicrobial activity[J]. Eur J Clin Invest, 2016,46(10):853⁃863. doi: 10.1111/eci.12667. |
[40] | Yagi H, Chen AF, Hirsch D, et al. Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus[J]. Stem Cell Res Ther, 2020,11(1):293. doi: 10.1186/s13287⁃020⁃01807⁃3. |
[41] | Harman RM, Yang S, He MK, et al. Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds[J]. Stem Cell Res Ther, 2017,8(1):157. doi: 10.1186/s13287⁃017⁃0610⁃6. |
[42] | Wang X, Shu X, Huo W, et al. Efficacy of protein extracts from medium of Adipose⁃derived stem cells via microneedles on Asian skin[J]. J Cosmet Laser Ther, 2018,20(4):237⁃244. doi: 10.1080/14764172.2017.1400171. |
[43] | Lee R, Ko HJ, Kim K, et al. Anti⁃melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin[J]. J Extracell Vesicles, 2020,9(1):1703480. doi: 10.1080/20013078.2019. 1703480. |
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