Chinese Journal of Dermatology ›› 2025, e20240063.doi: 10.35541/cjd.20240063

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Roles of periostin and its associated signaling pathways in keloids

Zhao Lei, Zhou Ming, Quan Xuemei, Cui Aili   

  1. Department of Medical Cosmetology, Yanbian University Hospital, Keloid and Hypertrophic Scar Research Center, Chinese Society of Dermatology, Key Laboratory of Dermatology and Venereology in Jilin Province, Yanji 133000, Jilin, China
  • Received:2024-01-31 Revised:2025-01-03 Online:2025-01-24 Published:2025-02-17
  • Contact: Cui Aili E-mail:13843397695@163.com
  • Supported by:
    Application Foundation Project of Yanbian University, Yanji(ydkj202229)

Abstract: 【Abstract】 Periostin is highly expressed in keloids. Upon binding to membrane-bound integrins, it activates downstream signaling pathways, including the phosphatidylinositol 3-kinase/serine-threonine protein kinase pathway and the extracellular signal-regulated kinase pathway. The interaction regulates fibroblast proliferation, migration, and differentiation, while also promotes angiogenesis, thereby playing a crucial role in keloid formation. This review focuses on the role of periostin and its associated signaling pathways in keloid pathogenesis, aiming to provide novel insights into potential therapeutic strategies for this disease.

Key words: Keloid, Periostin, Signaling pathway