Abstract: 【Abstract】 Hair follicles are skin appendages with a complex structure and periodically self-renewal ability. The hair cycle includes the anagen phase, catagen phase and telogen phase, and its orderly renewal is important to maintain hair growth. It is currently believed that Wnt, bone morphogenetic protein, and Notch signaling pathways are involved in regulating the hair cycle. As research progresses, various regulatory mechanisms based on these signaling pathways have been gradually revealed, such as growth factors, non-coding RNAs, immune responses, etc. This review elaborates on the above molecular mechanisms and regulatory modalities, aiming to better understand regulatory mechanisms underlying the hair cycle and provide a theoretical reference for expanding treatment options for hair loss.

Key words: Hair follicle, Alopecia, Hair cycle, Signaling pathway, Fibroblast growth factors