单细胞测序在毛发相关研究中的应用

doi:10.35541/cjd.20230292

Abstract

Abstract: 【Abstract】 Hair follicles are complex organs consisting of multiple cell types. Single-cell sequencing technology can identify the transcriptional characteristics of various cell types and subsets in tissues at the single-cell level, comprehensively revealing the heterogeneity among cell populations. This review focuses on the latest advances in the application of single-cell sequencing to the study of molecular characteristics of mouse and human hair follicle cells and cell fate regulation, as well as aging, microbial symbiosis, and the pathogenesis of hair loss and hair graying. Single-cell sequencing can serve as a novel tool for studying the morphogenesis, cell types, physiological and pathological states of hair follicles. It reveals important information that has not been found in traditional research, and is meaningful for hair-related studies.

Key words: Hair, Hair follicle, Sequence analysis, DNA, Single-cell sequencing, Alopecia, Hair graying

Yang Jie, Liu Liping. Application of single-cell sequencing in the hair research[J]. Chinese Journal of Dermatology, 2025, 58(7): 690-694.doi:10.35541/cjd.20230292

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Application of single-cell sequencing in the hair research

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