血管内皮生长因子在雄激素性脱发中的研究进展

doi:10.35541/cjd.20220240

Abstract

Abstract: 【Abstract】 The main pathological feature of androgenetic alopecia is the progressive miniaturization of hair follicles, which is closely related to vascular changes around hair follicles. Vascular endothelial growth factor interacts with dermal papilla cells and hair follicle stem cells to promote the formation of blood vessels around hair follicles, and to increase the nutrient supply to hair follicles, thereby promoting hair growth. This review summarizes research progress in the role of vascular endothelial growth factor in androgenetic alopecia.

Key words: Alopecia, Vascular endothelial growth factors, Therapy

Zhang Li, Song Xiuzu. Role of vascular endothelial growth factor in androgenetic alopecia[J]. Chinese Journal of Dermatology,2023,e20220240. doi:10.35541/cjd.20220240

References ［36］

［1］	Zhou Y, Yu S, Zhao J, et al. Effectiveness and safety of botulinum toxin type A in the treatment of androgenetic alopecia［J］. Biomed Res Int, 2020,2020:1501893. doi: 10.1155/2020/150 1893.
［2］	Faghihi G, Iraji F, Siadat AH, et al. Comparison between "5% minoxidil plus 2% flutamide" solution vs. "5% minoxidil" solution in the treatment of androgenetic alopecia［J/OL］. J Cosmet Dermatol, 2022［2022⁃05⁃30］. https://www.ncbi.nlm.nih.gov/pubmed/35152531. doi: 10.1111/jocd.14788.
［3］	Kozlowska U, Blume⁃Peytavi U, Kodelja V, et al. Expression of vascular endothelial growth factor （VEGF） in various compartments of the human hair follicle［J］. Arch Dermatol Res, 1998,290（12）:661⁃668. doi: 10.1007/s004030050370.
［4］	Chew E, Tan J, Bahta AW, et al. Differential expression between human dermal papilla cells from balding and non⁃balding scalps reveals new candidate genes for androgenetic alopecia［J］. J Invest Dermatol, 2016,136（8）:1559⁃1567. doi: 10.1016/j.jid.2016.03. 032.
［5］	Mecklenburg L, Tobin DJ, Müller⁃Röver S, et al. Active hair growth （anagen） is associated with angiogenesis［J］. J Invest Dermatol, 2000,114（5）:909⁃916. doi: 10.1046/j.1523⁃1747.2000. 00954.x.
［6］	Deng Z, Chen M, Liu F, et al. Androgen receptor⁃mediated paracrine signaling induces regression of blood vessels in the dermal papilla in androgenetic alopecia［J］. J Invest Dermatol, 2022,142（8）:2088⁃2099.e9. doi: 10.1016/j.jid.2022.01.003.
［7］	Chen P, Miao Y, Zhang F, et al. Tissue engineering ECM⁃enriched controllable vascularized human microtissue for hair regenerative medicine using a biomimetic developmental approach［J］. J Adv Res, 2022,38:77⁃89. doi: 10.1016/j.jare.2021. 09.010.
［8］	Park S, Kang W, Choi D, et al. Nonanal stimulates growth factors via cyclic adenosine monophosphate （cAMP） signaling in human hair follicle dermal papilla cells［J］. Int J Mol Sci, 2020,21（21）:8054. doi: 10.3390/ijms21218054.
［9］	Lachgar S, Charveron M, Gall Y, et al. Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells［J］. Br J Dermatol, 1998,138（3）:407⁃411. doi: 10.1046/j.1365⁃2133.1998.02115.x.
［10］	Lachgar S, Moukadiri H, Jonca F, et al. Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells［J］. J Invest Dermatol, 1996,106（1）:17⁃23. doi: 10.1111/1523⁃1747.ep12326964.
［11］	Bassino E, Gasparri F, Giannini V, et al. Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells［J］. Exp Dermatol, 2015,24（5）:388⁃390. doi: 10.1111/exd.12670.
［12］	Goldman CK, Tsai JC, Soroceanu L, et al. Loss of vascular endothelial growth factor in human alopecia hair follicles［J］. J Invest Dermatol, 1995,104（5 Suppl）:18S⁃20S. doi: 10.1038/jid. 1995.40.
［13］	Zhang X, Zhou D, Ma T, et al. Vascular endothelial growth factor protects CD200⁃rich and CD34⁃positive hair follicle stem cells against androgen⁃induced apoptosis through the phosphoinositide 3⁃kinase/Akt pathway in patients with androgenic alopecia［J］. Dermatol Surg, 2020,46（3）:358⁃368. doi: 10.1097/DSS.0000000 000002091.
［14］	Andjelkov K, Eremin II, Korac A. Different levels of EGF, VEGF, IL⁃6, MCP⁃1, MCP⁃3, IP⁃10, eotaxin and MIP⁃1α in the adipose⁃derived stem cell secretome in androgenetic alopecia［J］. Exp Dermatol, 2022,31（6）:936⁃942. doi: 10.1111/exd.14548.
［15］	Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF⁃mediated angiogenesis［J］. J Clin Invest, 2001,107（4）:409⁃417. doi: 10.1172/JCI11317.
［16］	Kapoor R, Shome D. Intradermal injections of a hair growth factor formulation for enhancement of human hair regrowth ⁃ safety and efficacy evaluation in a first⁃in⁃man pilot clinical study［J］. J Cosmet Laser Ther, 2018,20（6）:369⁃379. doi: 10.1080/14764172.2018.1439965.
［17］	Lee YB, Eun YS, Lee JH, et al. Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: a pilot study［J］. J Dermatol, 2013,40（1）:81⁃83. doi: 10.1111/j.1346⁃8138.2012.01680.x.
［18］	Zimber MP, Ziering C, Zeigler F, et al. Hair regrowth following a Wnt⁃ and follistatin containing treatment: safety and efficacy in a first⁃in⁃man phase 1 clinical trial［J］. J Drugs Dermatol, 2011,10（11）:1308⁃1312.
［19］	Siah TW, Guo H, Chu T, et al. Growth factor concentrations in platelet⁃rich plasma for androgenetic alopecia: an intra⁃subject, randomized, blinded, placebo⁃controlled, pilot study［J］. Exp Dermatol, 2020,29（3）:334⁃340. doi: 10.1111/exd.14074.
［20］	Li ZJ, Choi HI, Choi DK, et al. Autologous platelet⁃rich plasma: a potential therapeutic tool for promoting hair growth［J］. Dermatol Surg, 2012,38（7 Pt 1）:1040⁃1046. doi: 10.1111/j.1524⁃4725.2012.02394.x.
［21］	Steward EN, Patel H, Pandya H, et al. Efficacy of platelet⁃rich plasma and concentrated growth factor in treating androgenetic alopecia ⁃ a retrospective study［J］. Ann Maxillofac Surg, 2020,10（2）:409⁃416. doi: 10.4103/ams.ams_154_19.
［22］	Pakhomova EE, Smirnova IO. Comparative evaluation of the clinical efficacy of PRP⁃therapy, minoxidil, and their combination with immunohistochemical study of the dynamics of cell proliferation in the treatment of men with androgenetic alopecia［J］. Int J Mol Sci, 2020,21（18）:6516. doi: 10.3390/ijms21186516.
［23］	Lee SH, Ok SH, Kang D, et al. Nitric oxide⁃dependent vasodilation induced by minoxidil in isolated rat aorta［J］. Gen Physiol Biophys, 2021,40（3）:197⁃206. doi: 10.4149/gpb_2021012.
［24］	Oh HA, Kwak J, Kim BJ, et al. Migration inhibitory factor in conditioned medium from human umbilical cord blood⁃derived mesenchymal stromal cells stimulates hair growth［J］. Cells, 2020,9（6）:1344. doi: 10.3390/cells9061344.
［25］	Chen X, Liu B, Li Y, et al. Dihydrotestosterone regulates hair growth through the Wnt/β⁃catenin pathway in C57BL/6 mice and in vitro organ culture［J］. Front Pharmacol, 2019,10:1528. doi: 10.3389/fphar.2019.01528.
［26］	Li M, Marubayashi A, Nakaya Y, et al. Minoxidil⁃induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil［J］. J Invest Dermatol, 2001,117（6）:1594⁃1600. doi: 10.1046/j.0022⁃202x.2001.01570.x.
［27］	Meephansan J, Thummakriengkrai J, Ponnikorn S, et al. Efficacy of topical tofacitinib in promoting hair growth in non⁃scarring alopecia: possible mechanism via VEGF induction［J］. Arch Dermatol Res, 2017,309（9）:729⁃738. doi: 10.1007/s00403⁃017⁃1777⁃5.
［28］	Iwabuchi T, Ogura K, Tamba K, et al. Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia⁃inducible factor activation［J］. Clin Exp Dermatol, 2021,46（4）:694⁃703. doi: 10. 1111/ced.14533.
［29］	Shin JY, Choi YH, Kim J, et al. Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells［J］. BMC Complement Med Ther, 2020,20（1）:144. doi: 10. 1186/s12906⁃020⁃02940⁃5.
［30］	Kim BH, Lee MJ, Lee WY, et al. Hair growth stimulation effect of Centipeda minima extract: identification of active compounds and anagen⁃activating signaling pathways［J］. Biomolecules, 2021,11（7）:976. doi: 10.3390/biom11070976.
［31］	Choi M, Choi SJ, Jang S, et al. Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle［J］. Sci Rep, 2019,9（1）:17008. doi: 10.1038/s41598⁃019⁃53612⁃5.
［32］	Kim J, Shin JY, Choi YH, et al. Hair growth promoting effect of Hottuynia cordata extract in cultured human hair follicle dermal papilla cells［J］. Biol Pharm Bull, 2019,42（10）:1665⁃1673. doi: 10.1248/bpb.b19⁃00254.
［33］	Hwang D, Lee H, Lee J, et al. Micro⁃current stimulation has potential effects of hair growth⁃promotion on human hair follicle⁃derived papilla cells and animal model［J］. Int J Mol Sci, 2021,22（9）:4361. doi: 10.3390/ijms22094361.
［34］	Nakamura T, Yamamura H, Park K, et al. Naturally occurring hair growth peptide: water⁃soluble chicken egg yolk peptides stimulate hair growth through induction of vascular endothelial growth factor production［J］. J Med Food, 2018,21（7）:701⁃708. doi: 10.1089/jmf.2017.4101.
［35］	Wang Z, Nan W, Si H, et al. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA binding 3/Notch signaling pathway［J］. Life Sci, 2020,252:117667. doi: 10.1016/j.lfs.2020.117667.
［36］	Inan Yuksel E, Demir B, Cicek D, et al. Sodium pentaborate pentahydrate promotes hair growth through the Wnt/β⁃catenin pathway and growth factors［J］. J Trace Elem Med Biol, 2022,73:127007. doi: 10.1016/j.jtemb.2022.127007.

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Role of vascular endothelial growth factor in androgenetic alopecia

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