Chinese Journal of Dermatology ›› 2025, e20230301.doi: 10.35541/cjd.20230301

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Biologics for the treatment of psoriasis relapse: current status

Wang Wenqiu1, Li Chengxin2, Wang Rui2   

  1. 1Medical School of Chinese PLA, Beijing 100853, China; 2Department of Dermatology, the 1th Medical Center, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2023-05-26 Revised:2024-08-14 Online:2025-01-24 Published:2025-02-10
  • Contact: Wang Rui E-mail:wangruiderm@163.com
  • Supported by:
    National Natural Science Foundation of China(82273530); Beijing Municipal Natural Science Foundation (7224344)

Abstract: 【Abstract】 Psoriasis is a chronic, recurrent, systemic, inflammatory disease. Over the past 20 years, with the development and application of biologics targeting tumor necrosis factor (TNF) or TNF receptors, interleukin-17A (IL-17A) or IL-17A receptors, IL-23, and others, significant progress has been made in the treatment of psoriasis. However, recurrence remains a major challenge in the management of psoriasis after discontinuation of biologic therapy or during maintenance treatment. This review summarizes the recurrence of psoriasis following biologic treatment and proposes comprehensive management recommendations to prevent its recurrence.

Key words: Psoriasis, Recurrence, Biological agents, Tumor necrosis factor inhibitors, Interleukin inhibitors, Patient care management, Universal precautions