Chinese Journal of Dermatology ›› 2024, e20230394.doi: 10.35541/cjd.20230394

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Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway in the occurrence of psoriasis

Wu Yubing1, Wang Xiaoyu2, An Binyi3, Wu Yingying3, Sang Hong1,2,3, Kong Qingtao1,2,3   

  1. 1Department of Dermatology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210002, China; 2Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China; 3Department of Dermatology, Affiliated Jinling Hospital of Nanjing Medical University, Nanjing 210002, China
  • Received:2023-07-05 Revised:2023-10-27 Online:2024-01-29 Published:2024-02-06
  • Contact: Sang Hong; Kong Qingtao E-mail:sanghong@nju.edu.cn; njukqt@163.com
  • Supported by:
    Jiangsu Dermatology Innovation Team(CXTDA2017038)

Abstract: 【Abstract】 The pathogenesis of psoriasis involves both the innate and adaptive immune systems. The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway can identify disease-causing DNA and trigger innate immune responses. This review summarizes the role of the cGAS-STING signaling pathway in the pathogenesis of psoriasis and the research progress on related targeted drugs, providing a reference for further studies.

Key words: Psoriasis, Interferon type I, cGAS-STING signaling pathway