Chinese Journal of Dermatology ›› 2023, e20220556.doi: 10.35541/cjd.20220556

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Role of transforming growth factor-β/Smad pathway and related factors in the pathogenesis of keloids

Huang Wenhua, Zheng Zhenlong, Jin Zhehu   

  1. Department of Dermatology, Yanbian University Hospital, Jilin 133000, China
  • Received:2022-08-08 Revised:2023-06-17 Online:2023-01-05 Published:2023-12-15
  • Contact: Jin Zhehu
  • Supported by:
    National Natural Science Foundation of China(82060569)

Abstract: 【Abstract】 The transforming growth factor-beta (TGF-β)/Smad pathway is crucial in the differentiation of keloid fibroblasts and the development of keloids. Hypoxia-inducible factor 1α, microRNAs, long non-coding RNAs, activating transcription factor 3, inflammatory factors and lysyl oxidase-like 2 are common factors in the TGF-β/Smad pathway during the occurrence of keloids. This review summarizes latest research progress on the TGF-β/Smad pathway and common factors in the pathogenesis of keloids.

Key words: Keloid, Fibroblasts, Fibrosis, Transforming growth factor beta, Smad proteins, receptor-regulated