转化生长因子β/Smad信号通路及相关影响因子在瘢痕疙瘩中的研究进展

doi:10.35541/cjd.20220556

Abstract

Abstract: 【Abstract】 The transforming growth factor-beta （TGF-β）/Smad pathway is crucial in the differentiation of keloid fibroblasts and the development of keloids. Hypoxia-inducible factor 1α, microRNAs, long non-coding RNAs, activating transcription factor 3, inflammatory factors and lysyl oxidase-like 2 are common factors in the TGF-β/Smad pathway during the occurrence of keloids. This review summarizes latest research progress on the TGF-β/Smad pathway and common factors in the pathogenesis of keloids.

Key words: Keloid, Fibroblasts, Fibrosis, Transforming growth factor beta, Smad proteins, receptor-regulated

Huang Wenhua, Zheng Zhenlong, Jin Zhehu. Role of transforming growth factor-β/Smad pathway and related factors in the pathogenesis of keloids[J]. Chinese Journal of Dermatology,2023,e20220556. doi:10.35541/cjd.20220556

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Role of transforming growth factor-β/Smad pathway and related factors in the pathogenesis of keloids

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