长链非编码RNA介导的竞争性内源RNA调控网络在瘢痕疙瘩中的研究进展

doi:10.35541/cjd.20210471

Abstract

Abstract: 【Abstract】 Long non-coding RNAs （lncRNAs） are aberrantly expressed in keloids, and some lncRNAs can interact with miRNAs and act as competitive endogenous RNAs （ceRNAs） to regulate downstream mRNA expression. These RNA molecules are interconnected to form a complex ceRNA regulatory network, playing an important role in the occurrence and development of keloids. This review summarizes the relationship between lncRNAs and their mediated ceRNA regulatory networks and keloids, in order to further explore the pathogenesis of keloids.

Key words: Keloid, Gene regulatory networks, MicroRNAs, Long non-coding RNA, Competitive endogenous RNA

Zhu Xue′e, Duan Manman, Ding Yuan. Long non-coding RNA-mediated competitive endogenous RNA regulatory network in keloids[J]. Chinese Journal of Dermatology,2023,e20210471. doi:10.35541/cjd.20210471

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Long non-coding RNA-mediated competitive endogenous RNA regulatory network in keloids

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