Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (10): 985-988.doi: 10.35541/cjd.20210099

• Reviews • Previous Articles    

Mechanism of action of long non-coding RNA in cutaneous squamous cell carcinoma

Li Rong, Chen Kun, Zhang Jiaan   

  1. Department of Physiotherapy, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2021-01-29 Revised:2022-01-09 Online:2023-10-15 Published:2023-10-08
  • Contact: Chen Kun
  • Supported by:
    National Natural Science Foundation of China(81703152、81872545、82073445)

Abstract: 【Abstract】 Long non-coding RNAs (lncRNAs) participate in the occurrence and development of cutaneous squamous cell carcinoma (cSCC) mainly through epigenetic modification, mRNA alternative splicing, and binding to microRNAs. This review focuses on recent research progress in regulatory role of lncRNAs in cSCC, and discusses its mechanisms of action, aiming to seek potential therapeutic targets and biomarkers for cSCC.

Key words: Long non-coding RNA, Pathogenesis, Cutaneous squamous cell carcinoma