Abstract: 【Abstract】 Dermatitis herpetiformis is an autoimmune bullous disease associated with celiac disease, which occurs mostly in Caucasians carrying HLA-DQ2 or HLA-DQ8 alleles. Studies have shown a variety of antibodies against transglutaminase and other antigens in the serum of patients with dermatitis herpetiformis, and epidermal transglutaminase is an autoantigen. The occurrence of dermatitis herpetiformis is not only associated with genetics and gluten sensitivity, but may also be related to the imbalance of intestinal microbiome. Gluten-free diet and dapsone are still the main therapies for dermatitis herpetiformis. This review summarizes epidemiological features, pathogenesis, clinical manifestations, laboratory findings, diagnosis and treatment of dermatitis herpetiformis.

Key words: Dermatitis herpetiformis, Celiac disease, Diagnosis, Therapy, Pathogenesis, Serologic tests