Abstract: 【Abstract】 Objective To compare efficacy and safety of 308-nm SQ light-emitting diode （LED） light versus 308-nm excimer light in the treatment of facial vitiligo. Methods Patients with stable facial vitiligo were retrospectively collected from Department of Physical Therapy, Hospital of Dermatology, Chinese Academy of Medical Sciences from June 2018 to June 2020, who received treatment with 308-nm SQ LED light （LED group） or 308-nm excimer light （excimer light group）. The treatment was performed once or twice a week, and patients who had received more than 8 sessions of treatment were included in the analysis of efficacy and safety. Statistical analysis was carried out by using chi-square test. Results Totally, 68 patients with 90 lesions were enrolled into the LED group, including 36 males and 32 females, aged 25.01 ± 13.37 years; 20 patients with 28 lesions were enrolled into the excimer light group, including 13 males and 7 females, aged 27.15 ± 14.30 years. After 8 and 16 sessions of treatment, there was no significant difference in the response rate between the LED group （23.33%, 46.67%, respectively） and excimer light group （14.29%, 46.43%, χ2 = 1.05, < 0.001, respectively, both P > 0.05）. During the treatment, 36 （52.94%） patients in the LED group developed persistent erythema, 17 （85%） in the excimer light group developed persistent erythema or blisters. The incidence of adverse reactions was significantly lower in the LED group than in the excimer light group （χ2 = 16.43, P < 0.001）. Conclusion Compared with the 308-nm excimer light, the 308-nm SQ LED light showed similar effect but higher safety for the treatment of facial vitiligo.

Key words: Vitiligo, Ultraviolet therapy, 308-nm SQ light-emitting diode light, 308-nm excimer light, Clinical efficacy, Safety