长链非编码RNA在皮肤良恶性增生性疾病中的研究进展

doi:10.35541/cjd.20210118

Abstract

Abstract: 【Abstract】 Long non-coding RNAs （lncRNAs） are a group of non-coding RNAs with the length of over 200 nucleotides. Recently, studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and post-transcriptional levels, affect the proliferation, migration, and infiltration of tumor cells, and participate in the occurrence and development of benign and malignant proliferative skin diseases, such as keloids, hemangioma, squamous cell carcinoma and melanoma. This review summarizes roles of lncRNAs in the pathogenesis of benign and malignant proliferative skin diseases.

Key words: Skin neoplasms, Gene expression regulation, RNA, noncoding, Long non-coding RNA

Yang Xiao, Zeng Yanchao, He Li, Wu Wenjuan. Long non-coding RNAs in benign and malignant proliferative skin diseases[J]. Chinese Journal of Dermatology, 2023, 56(11): 1080-1084.doi:10.35541/cjd.20210118

References ［39］

［1］	Hu W, Alvarez⁃Dominguez J RLodish HF, Regulation of mammalian cell differentiation by long non⁃coding RNAs［J］. EMBO Reports, 2012,13（11）:971⁃983. doi: 10.1038/embor.2012. 145.
［2］	Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?［J］. Cell, 2011,146（3）:353⁃358. doi: 10.1016/j.cell.2011.07.014.
［3］	Nong Q, Li S, Wu Y, et al. LncRNA COL1A2⁃AS1 inhibits the scar fibroblasts proliferation via regulating miR⁃21/Smad7 pathway［J］. Biochem Biophys Res Commun, 2018,495（1）:319⁃324. doi: 10.1016/j.bbrc.2017.11.027.
［4］	Zhu HY, Bai WD, Li C, et al. Knockdown of lncRNA⁃ATB suppresses autocrine secretion of TGF⁃β2 by targeting ZNF217 via miR⁃200c in keloid fibroblasts［J］. Sci Rep, 2016,6:24728. doi: 10.1038/srep24728.
［5］	Zhang J, Zhao T, Tian L, et al. LncRNA OIP5⁃AS1 promotes the proliferation of hemangioma vascular endothelial cells via regulating miR⁃195⁃5p/NOB1 axis［J］. Front Pharmacol, 2019,10:449. doi: 10.3389/fphar.2019.00449.
［6］	Yu X, Liu X, Wang R, et al. Long non⁃coding RNA NEAT1 promotes the progression of hemangioma via the miR⁃361⁃5p/VEGFA pathway［J］. Biochem Biophys Res Commun, 2019,512（4）:825⁃831. doi: 10.1016/j.bbrc.2019.03.084.
［7］	Wang SJ, Li YJ, Gao B, et al. Long non⁃coding RNA 00152 slicing represses the growth and aggressiveness of hemangioma cell by modulating miR⁃139⁃5p［J］. Biomed Pharmacother, 2019,120:109385. doi: 10.1016/j.biopha.2019.109385.
［8］	Liu Z, Kang Z, Dai Y, et al. Long noncoding RNA LINC00342 promotes growth of infantile hemangioma by sponging miR⁃3619⁃5p from HDGF［J］. Am J Physiol Heart Circ Physiol, 2019,317（4）:H830⁃H839. doi: 10.1152/ajpheart.00188.2019.
［9］	Li X, Chen B, Chi D, et al. lncRNA CASC9 regulates cell migration and invasion in hemangioma endothelial cells by targeting miR⁃125a⁃3p/Nrg1［J］. Onco Targets Ther, 2019,12:423⁃432. doi: 10.2147/OTT.S181914.
［10］	Dai Y, Wan Y, Qiu M, et al. lncRNA MEG3 suppresses the tumorigenesis of hemangioma by sponging miR⁃494 and regulating PTEN/ PI3K/AKT pathway［J］. Cell Physiol Biochem, 2018,51（6）:2872⁃2886. doi: 10.1159/000496040.
［11］	Piipponen M, Heino J, Kähäri VM, et al. Long non⁃coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression［J］. Biol Open, 2018,7（11）:bio037044. doi: 10.1242/bio.037044.
［12］	郑云鹏, 李旭阳, 蔡丙杰, 等. lncRNA LEF1⁃AS1通过靶向miR⁃612调控皮肤鳞状细胞癌细胞株增殖、凋亡、迁移侵袭的体外实验研究［J］. 中华皮肤科杂志, 2020,53（6）:415⁃423. doi: 10. 35541/cjd.20191053.
［13］	郑云鹏, 蔡丙杰, 李旭阳, 等. lncRNA DLX6⁃AS1通过靶向miR⁃16⁃5p/NUCKS1调控皮肤鳞状细胞癌细胞A431增殖、迁移和侵袭［J］. 中华皮肤科杂志, 2020,53（8）:607⁃615. doi: 10.35541/cjd.20191057.
［14］	许文, 刘绪宏, 刘华. 下调HOXA⁃AS2/miR⁃20a通路促进皮肤鳞癌细胞凋亡并抑制其侵袭迁移［J］. 第三军医大学学报, 2020,42（20）:2003⁃2011. doi: 10.16016/j.1000⁃5404.202005261.
［15］	Mei XL, Zhong S, Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR［J］. Chin Med J （Engl）, 2019,132（4）: 454⁃465. doi:10.1097/CM9.0000000000000070.
［16］	Zhou W, Zhang S, Li J, et al. lncRNA TINCR participates in ALA⁃PDT⁃induced apoptosis and autophagy in cutaneous squamous cell carcinoma［J］. J Cell Biochem, 2019,120（8）:13893⁃13902. doi: 10.1002/jcb.28662.
［17］	Ni N, Song H, Wang X, et al. Up⁃regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21［J］. Biomed Pharmacother, 2017,96:1371⁃1379. doi: 10.1016/j.biopha.2017. 11.060.
［18］	Wang BJ, Ding HW, Ma GA. Long noncoding RNA PVT1 promotes melanoma progression via endogenous sponging miR⁃26b［J］. Oncol Res, 2018,26（5）:675⁃681. doi: 10.3727/0965040 17X14920318811730.
［19］	Mou K, Liu B, Ding M,et al, lncRNA⁃ATB functions as a competing endogenous RNA to promote YAP1 by sponging miR⁃590⁃5p in malignant melanoma［J］. Int J Oncol, 2018,53（3）:1094⁃1104. doi: 10.3892/ijo.2018.4454.
［20］	Zhao H, Xing G, Wang Y, et al. Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of miR⁃200b/a/429［J］. Biosci Rep, 2017,37（3）:BSR20170682. doi: 10.1042/BSR20170682.
［21］	Chen X, Liu S, Zhao X, et al. Long noncoding RNA ILF3⁃AS1 promotes cell proliferation, migration, and invasion via negatively regulating miR⁃200b/a/429 in melanoma［J］. Biosci Rep, 2017,37（6）:BSR2017103. doi: 10.1042/BSR20171031.
［22］	Bian D, Shi W, Shao Y, et al. Long non⁃coding RNA GAS5 inhibits tumorigenesis via miR⁃137 in melanoma［J］. Am J Transl Res, 2017,9（3）:1509⁃1520.
［23］	张杨蕊, 庞霞, 薛金慧. lncRNA⁃EGFR⁃AS1改变EGFR表达对黑素瘤细胞增殖、转移和凋亡的影响［J］. 中国皮肤性病学杂志, 2020,34（9）:982⁃987. doi: 10.13735/j.cjdv.1001⁃7089.2020 01026.
［24］	Luan W, Ding Y, Yuan H, et al. Long non⁃coding RNA LINC00520 promotes the proliferation and metastasis of malignant melanoma by inducing the miR⁃125b⁃5p/EIF5A2 axis［J］. J Exp Clin Cancer Res, 2020,39（1）:96. doi: 10.1186/s13046⁃020⁃01599⁃7.
［25］	Wei X, Gu X, Ma M, et al. Long noncoding RNA HCP5 suppresses skin cutaneous melanoma development by regulating RARRES3 gene expression via sponging miR⁃12［J］. Onco Targets Ther, 2019,12:6323⁃6335. doi: 10.2147/OTT.S195796.
［26］	Zhiqing Li, Xuefeng TangDuan S, Interference from LncRNA SPRY4⁃IT1 restrains the proliferation, migration, and invasion of melanoma cells through inactivating MAPK pathway by up⁃regulating miR⁃22⁃3p［J］. Int J Clin Exp Pathol, 2019,12（2）:477⁃487.
［27］	Cai B, Zheng Y, Ma S, et al. BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR⁃204［J］. Int J Oncol, 2017,51（6）:1941⁃1951. doi: 10.3892/ijo.2017.4173.
［28］	Xia Y, Zhou Y, Han H, et al. lncRNA NEAT1 facilitates melanoma cell proliferation, migration, and invasion via regulating miR⁃495⁃3p and E2F3［J］. J Cell Physiol, 2019,234（11）:19592⁃19601. doi: 10.1002/jcp.28559.
［29］	Luan W, Zhou Z, Ni X, et al. Long non⁃coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR⁃106a⁃5p/E2F3 axis［J］. J Cancer Res Clin Oncol, 2018,144（3）:531⁃542. doi: 10.1007/s00432⁃018⁃2582⁃z.
［30］	Zhang Y, Qian W, Feng F, et al. Upregulated lncRNA CASC2 May Inhibit Malignant Melanoma Development Through Regulating miR⁃18a⁃5p/RUNX1［J］. Oncol Res, 2019,27（3）:371⁃377. doi: 10.3727/096504018X15178740729367.
［31］	Long J, Menggen Q, Wuren Q, et al. Long Noncoding RNA taurine⁃upregulated gene1 （TUG1） promotes tumor growth and metastasis through TUG1/Mir⁃129⁃5p/astrocyte⁃elevated gene⁃1 （AEG⁃1） axis in malignant melanoma［J］. Med Sci Monit, 2018,24:1547⁃1559. doi: 10.12659/msm.906616.
［32］	Wang Y, Liu G, Ren L, et al. Long non⁃coding RNA TUG1 recruits miR⁃29c⁃3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells［J］. Int J Oncol, 2019,54（4）:1317⁃1326. doi: 10.3892/ijo.2019.4699.
［33］	李程彬, 陈佳, 李婷, 等. DANCR通过激活YAP促进黑素瘤细胞侵袭并与不良预后的相关性［J］. 中国皮肤性病学杂志, 2020,34（10）:1104⁃1109. doi: 10.13735/j.cjdv.1001⁃7089.2019 12047.
［34］	Luan W, Li R, Liu L, et al. Long non⁃coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR⁃152⁃3p［J］. Oncotarget, 2017,8（49）:85401⁃85414. doi: 10.18632/oncotarget.19910.
［35］	Tang L, Zhang W, Su B, et al. Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma［J］. Biomed Res Int, 2013,2013:251098. doi: 10.1155/2013/251098.
［36］	Wei Y, Sun Q, Zhao L, et al. LncRNA UCA1⁃miR⁃507⁃FOXM1 axis is involved in cell proliferation, invasion and G0/G1 cell cycle arrest in melanoma［J］. Med Oncol, 2016,33（8）:88. doi: 10.1007/s12032⁃016⁃0804⁃2.
［37］	Han C, Tang F, Chen J, et al, Knockdown of lncRNA⁃UCA1 inhibits the proliferation and migration of melanoma cells through modulating the miR⁃28⁃5p/HOXB3 axis［J］. Exp Ther Med, 2019.17（5）:4294⁃4302. doi: 10.3892/etm.2019.7421.
［38］	Hong CH, Lin SH, Lee CH. CCL21 Induces mTOR⁃dependent MALAT1 expression, leading to cell migration in cutaneous T⁃cell lymphoma［J］. In Vivo, 2019,33（3）:793⁃800. doi: 10.21873/ invivo.11541.
［39］	Lee CS, Ungewickell A, Bhaduri A, et al. Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides⁃associated lncRNAs and novel transcripts［J］. Blood, 2012,120（16）:3288⁃3297. doi: 10.1182/blood⁃2012⁃04⁃423061.

[1]	Yue Chao, Duan Mengying, Wang Tao, Zhang Manyu, Dai Yeqin, Peng Jianzhong, Song Xiuzu. Application of the upper eyelid orbicularis oculi myocutaneous island flap in repairing secondary defects after resection of eyelid and periorbital skin tumors: a retrospective analysis of 28 cases [J]. Chinese Journal of Dermatology, 2023, 56(9): 862-865.
[2]	Lian Panpan, Liu Jun, Su Zhonglan, Wang Hongwei. Effect of peroxisome proliferator-activated receptor γ on skin physiological and pathological processes [J]. Chinese Journal of Dermatology, 2023, 56(4): 365-368.
[3]	Zhang Jiaqi, Wu Fan, Han Yuqing, Liu Qi, Pan Yao. Application of multi-photon microscopy in dermatology [J]. Chinese Journal of Dermatology, 2023, 0(2): 20230022-e20230022.
[4]	Hao Feng, Liu Guoyan. Application of optical coherence tomography in dermatology [J]. Chinese Journal of Dermatology, 2023, 0(2): 20220353-e20220353.
[5]	Zhu Xue′e, Duan Manman, Ding Yuan. Long non-coding RNA-mediated competitive endogenous RNA regulatory network in keloids [J]. Chinese Journal of Dermatology, 2023, 0(2): 20210471-e20210471.
[6]	Zheng Nana, Zeng Rong, Tao Yingkai, Li Min, . Relationship between circular RNAs and skin tumors [J]. Chinese Journal of Dermatology, 2023, 0(2): 20210893-e20210893.
[7]	Li Rong, Chen Kun, Zhang Jiaan. Mechanism of action of long non-coding RNA in cutaneous squamous cell carcinoma [J]. Chinese Journal of Dermatology, 2023, 56(10): 985-988.
[8]	Chen Wenjing, Shao Rui, Zou Yunmin, Meng Zhongqin, Yan Qiao, Song Linyi, Sun Jianfang, Chen Hao. Clinical and pathological analysis of 8 cases of mucoepidermoid carcinoma [J]. Chinese Journal of Dermatology, 2022, 55(8): 665-668.
[9]	Feng Hua, Gao Yingshu, Li Qing, Sun Lianwen. Cell mechanics in dermatology [J]. Chinese Journal of Dermatology, 2022, 55(7): 641-644.
[10]	Wei Feng, Zhang Xiaoguang, Han Wenrui, Rong Rong, Wang Lijuan, Zhao Yike, Li Yanling. Efficacy of combined local flaps in repair of larger defects in the nasal and perinasal region after Mohs micrographic surgery in 11 cases [J]. Chinese Journal of Dermatology, 2022, 55(12): 1096-1098.
[11]	Chen Liyong, Chen Liuqing, Chen Hongying, Jiang Qian, Ma Ling, Huang Meng, Xia Yun. Dermoscopic characteistics of trichoblastoma: a preliminary investigation [J]. Chinese Journal of Dermatology, 2022, 55(10): 879-881.
[12]	Wu Yuhao, Zhang Guolong, Wang Xiuli. Tertiary lymphoid structures in malignant melanoma [J]. Chinese Journal of Dermatology, 2021, 54(9): 827-830.
[13]	Liu Qian, Li Guohong, Chen Bingwei. A survey on quality of life and its influencing factors among patients with non-melanoma skin cancers [J]. Chinese Journal of Dermatology, 2021, 54(9): 819-821.
[14]	Zhang Xiao, Fu Meng, Wang Lei, Liu Yu, Gao Tianwen, Liu Ling. Analysis of 118 cases of clinically misdiagnosed cutaneous melanoma [J]. Chinese Journal of Dermatology, 2021, 54(9): 771-776.
[15]	Wang Daguang, Jiang Jiayi. Considerations in the diagnosis and treatment of several nail diseases [J]. Chinese Journal of Dermatology, 2021, 54(8): 733-737.

Long non-coding RNAs in benign and malignant proliferative skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［39］

Related Articles 15

Metrics

Comments

Recommended 10