Chinese Journal of Dermatology ›› 2021, Vol. 54 ›› Issue (9): 827-830.doi: 10.35541/cjd.20200489

• Reviews • Previous Articles     Next Articles

Tertiary lymphoid structures in malignant melanoma

Wu Yuhao, Zhang Guolong, Wang Xiuli   

  1. Institute of Photomedicine, Tongji University School of Medicine, Department of Photomedicine, Shanghai Skin Disease Hospital, Shanghai 200443, China
  • Received:2020-05-20 Revised:2020-09-21 Online:2021-09-15 Published:2021-09-02
  • Contact: Wang Xiuli
  • Supported by:
    National Natural Science Foundation of China(81872212)

Abstract: 【Abstract】 Tumor microenvironment is one of the key factors affecting the prognosis of malignant tumors, and tertiary lymphoid structures are a new target for enhancing anti-tumor immunity in the local microenvironment. There are lymphocyte aggregates similar to tertiary lymphoid structures in the skin, suggesting the possibility of their existence in many skin diseases. Previous studies have confirmed the existence of tertiary lymphoid structures in malignant melanoma and their associations with a better prognosis of patients. This review summarizes the progress in skin-associated lymphoid tissues, tertiary lymphoid structures and function in malignant melanoma, and the role of tertiary lymphoid structures in the evaluation of prognosis of patients.

Key words: Melanoma, Skin neoplasms, Tertiary lymphoid structures, Tumor immune microenvironment