Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (4): 365-368.doi: 10.35541/cjd.20200947

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Effect of peroxisome proliferator-activated receptor γ on skin physiological and pathological processes

Lian Panpan1, Liu Jun2, Su Zhonglan3, Wang Hongwei1   

  1. 1Medical School of Nanjing University, State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, China; 2Department of Dermatology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210093, China; 3Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2020-09-25 Revised:2021-04-06 Online:2023-04-15 Published:2023-03-31
  • Contact: Wang Hongwei; Su Zhonglan;
  • Supported by:
    National Natural Science Foundation of China (81773326); Natural Science Foundation of Jiangsu Province (BE2019676, BK20171117); Nanjing Medical Science and Technology Development Projects (YKK17081)

Abstract: 【Abstract】 Peroxisome proliferator-activated receptors (PPARs) are widely involved in lipid metabolism, glucose metabolism, cell growth and differentiation, and inflammation in the human body. PPARγ agonists can inhibit skin inflammatory response, protect epidermal barrier function, and repair skin injury. This review summarizes various roles of PPARγ in skin biology, and discusses its function in skin diseases, such as psoriasis and skin tumors.

Key words: Peroxisome proliferator-activated receptors, Inflammation, Wounds and injuries, Skin aging, Skin neoplasms, Psoriasis