Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (5): 455-458.doi: 10.35541/cjd.20220076

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Collagen peptide against chronological skin aging: mechanisms of action and related clinical studies

Liu Lu1,2, Yin Cuiyuan1,2, Hu Hongzhong3, He Linlin1,2,4   

  1. 1School of Biological Sciences and Engineering, Shaanxi University of Technology, Hanzhong 723001, Shaanxi, China; 2China Institute of Vitamin D Physiology and Applications, Shaanxi University of Technology, Hanzhong 723001, Shaanxi, China; 3Hanzhong Tianze Jiayuan Agriculture and Forestry Technology Co. LTD, Hanzhong 723001, Shaanxi, China; 4China State Key Laboratory of Qinba Biological Resources and Ecological Environment (cultivated), Shaanxi University of Technology, Hanzhong 723001, Shaanxi, China
  • Received:2022-01-29 Revised:2022-10-09 Online:2023-05-15 Published:2023-05-04
  • Contact: He Linlin
  • Supported by:
    Natural Science Basic Research Program of Shaanxi Province (2018JM3033); Innovation Team Support Plan of Shaanxi "Sanqin Scholars" (Shaanxi Group Tongzi [2018]34); Horizontal Project on the Collagen Peptide of Giant Salamander Skin (H20220046)

Abstract: 【Abstract】 In recent years, collagen peptide (CP) has become a research hotspot in delaying chronological skin aging. Animal experiments have shown that CP can repair chronologically aged animal skin by promoting collagen synthesis, inhibiting collagen degradation, and increasing antioxidant enzyme activity. Cell experiments showed that CP can promote proliferation of fibroblasts and synthesis of collagen and elastin by stimulating nuclear factor-κB signaling pathway and transforming growth factor-β/drosophila mothers against decapentaplegic signaling pathway. Clinical studies have demonstrated that long-term oral supplement with CP or CP in combination with other antioxidant active substances can increase the skin moisture content and reduce transepidermal water loss, improve skin wrinkles and elasticity, as well as improve the skin collagen fiber structure, dermal and epidermal quality and the overall condition of facial skin. This review summarizes recent studies on mechanisms underlying chronological skin aging and mechanisms of action of CP in repairing chronologically aged skin, in order to provide a theoretical basis for further clinical research into and application of CP in repairing chronologically aged skin.

Key words: Skin aging, Animal experimentation, Cell experiments, Collagen peptide, Chronological skin aging, Clinical research