Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (11): 1080-1084.doi: 10.35541/cjd.20210118

• Reviews • Previous Articles    

Long non-coding RNAs in benign and malignant proliferative skin diseases

Yang Xiao, Zeng Yanchao, He Li, Wu Wenjuan   

  1. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming 650032, China
  • Received:2021-02-02 Revised:2021-11-07 Online:2023-11-15 Published:2023-11-03
  • Contact: Wu Wenjuan
  • Supported by:
    National Natural Science Foundation of China(81760559); Yunnan Science and Technology Leading Talents Project (2017HB044)

Abstract: 【Abstract】 Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs with the length of over 200 nucleotides. Recently, studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and post-transcriptional levels, affect the proliferation, migration, and infiltration of tumor cells, and participate in the occurrence and development of benign and malignant proliferative skin diseases, such as keloids, hemangioma, squamous cell carcinoma and melanoma. This review summarizes roles of lncRNAs in the pathogenesis of benign and malignant proliferative skin diseases.

Key words: Skin neoplasms, Gene expression regulation, RNA, noncoding, Long non-coding RNA