Abstract: 【Abstract】 Objective To investigate quality of life and its influencing factors among patients with non-melanoma skin cancers （NMSC）. Methods From June 2017 to January 2020, demographic, clinical and behavioral data were collected from 153 inpatients with NMSC, who received surgeries in Department of Plastic Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, by using a self-made questionnaire and the dermatology life quality index （DLQI） scale, and DLQI score was calculated to evaluate the quality of life of the patients. Chi-square test, Kruskal-Wallis H test, and multivariate logistic regression model were used to analyze factors influencing the quality of life of NMSC patients. Results A total of 146 （95.4%） valid questionnaires were collected. The 146 patients were 31 - 92 years old, and 101 （69.2%） of them were over 60 years old, and 59 （40.4%） had a history of long-term ultraviolet exposure. There were 66 cases （45.2%） of basal cell carcinoma （BCC）, 57 （39.0%） of invasive squamous cell carcinoma （SCC）, 16 （11.0%） of extramammary Paget disease and 7 （4.8%） of Bowen disease. The median DLQI score （M［P25, P75］） was 3 （1, 7）. The quality of life were affected in 99 （67.8%） patients, including 52 （35.6%） mildly affected, and 47 （32.2%） moderately to extremely severely affected. Multivariate logistic regression analysis showed that the skin cancer type, long-term ultraviolet exposure history, and having 3 or more children affected the quality of life of the patients with NMSC. Conclusion NMSC decrease the quality of life of the patients, and the type of skin cancers, history of long-term ultraviolet exposure and number of children are the factors influencing the quality of life of patients with NMSC.

Key words: Skin neoplasms, Quality of life, Sickness impact profile, Questionnaires