【Abstract】 Acne vulgaris （abbreviated as acne） is a common aesthetic-impairing dermatological disease that markedly affects appearance, and is characterized by diverse clinical manifestations. At present, there are various grading systems for acne severity, while there is still a lack of unified standards for objectively assessing disease severity to guide treatment selection and scientifically evaluating the efficacy of acne therapies, which are also highly concerned issues for clinicians. To address this, the Acne Study Group of China Dermatologist Association, the Dermatology Professional Committee of Chinese Research Hospital Association, and the Acne Study Group of Dermatology and Venereology Professional Committee of Chinese Association of Integrative Medicine organized a group of experts in the field of acne diagnosis and treatment in China to develop the "Chinese expert consensus on clinical severity grading and therapeutic evaluation of acne vulgaris" after extensive discussions, aiming to provide a reference for dermatologists in clinical practice.

【Abstract】 Dermatitis and eczematous diseases are the most common group of diseases in dermatology. Currently, aside from atopic dermatitis, standardized clinical guidelines on the diagnosis and management of dermatitis and eczematous diseases remain lacking in China. Based on the “Expert consensus on standardized diagnostic terminology of dermatitis and eczematous diseases”, the Chinese Society of Dermatology and the China Dermatologist Association convened experts to develop the guidelines in accordance with the Delphi method. The guidelines address the clinical classification and characteristics of these conditions, diagnostic and therapeutic approaches to localized and generalized eczematous lesions, and principles of classified treatment, in order to further update the understanding of dermatitis and eczematous diseases and to provide guidance on standardized clinical diagnosis and treatment for dermatologists.

【Abstract】 Topical medications form the cornerstone of atopic dermatitis （AD） treatment, and their standardized application is crucial for optimizing therapeutic efficacy and reducing the incidence of adverse reactions. Developed by a multidisciplinary expert team, this consensus is meticulously crafted based on evidence-based medicine for AD, Chinese and international guidelines, and expert clinical experience, and is closely tailored to the disease characteristics of Chinese AD patients. The consensus systematically outlines the application principles of classic and emerging topical agents, emphasizes strategies of stepwise therapy and proactive maintenance treatment, and establishes specific medication protocols for special anatomical sites and vulnerable populations. Aiming to provide clinicians with systematic, scientific, and standardized medication guidance, this consensus seeks to enhance the overall management of AD.

【Abstract】 Localized scleroderma （LS） is a rare skin disorder characterized by fibrosis in the dermis and subcutaneous tissues. In severe cases, it can affect patients′ appearance, physical function, and quality of life. Currently, there is a lack of Chinese guidelines or consensus on the diagnosis and treatment of LS, leading to variability in clinical practice. To enhance dermatologists′ understanding of LS and standardize its diagnosis and management, the Chinese Society of Dermatology and the China Dermatologist Association organized a panel of leading experts in the field of dermatology to develop a consensus through systematic literature review and integration of recent Chinese and international research advances. The consensus comprehensively summarized the clinical subtypes, diagnostic criteria, differential diagnoses, and assessment methods of LS, as well as treatment strategies for LS, aiming to provide evidence-based guidance for standardizing the clinical management of LS in China.

【Abstract】 Cancer treatment-related cutaneous adverse events （TRCAEs） are critical issues that significantly affect patients′ quality of life and treatment adherence. Approximately two-thirds of cancer patients develop at least one type of TRCAE within 3 months of therapy, and about one-third discontinue treatment as a result. In response, experts from the Committee on Skin Disease and Cosmetic Dermatology, China Association of Medical Equipment, the Patient Education Expert Committee, Chinese Society of Clinical Oncology, and other related fields jointly developed the “Chinese expert consensus on multidisciplinary management of cancer treatment-related cutaneous adverse events （2026 edition）”. This consensus pioneers a multidisciplinary team framework integrating oncology, dermatology, nursing, and pharmacy. It establishes standardized tiered interventions and evidence-based management strategies for 7 major categories of TRCAEs, encompassing prevention, basic care, pharmacotherapy, and traditional Chinese medicine. Special attention is given to individualized treatment adjustments and nursing guidance for specific patient populations. Furthermore, the consensus emphasizes the importance of patient education and explores the adjunctive application of dermocosmetics. This consensus aims to offer evidence-based, standardized guidance for clinical practice, thereby helping to improve patient outcomes and quality of life.

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【Abstract】 Rosacea is a kind of recurrent inflammatory skin disease that predominantly occurs on the face, significantly impacting the physical and mental health of patients. Properly guiding patients to understand rosacea, avoid potential triggers, and receive standardized treatment and skincare are important measures for effectively controlling the condition and preventing disease recurrence. Therefore, how to guide clinicians to provide patient education in a scientific, rational, and standardized way is particularly important. In order to enhance the awareness among Chinese clinicians regarding the importance of patient education for rosacea and to form unified and standardized guidance principles, the Chinese Society of Dermatology, the China Dermatologist Association, the Combination of Traditional and Western Medicine Dermatology, and the Chinese Non-Government Dermatologist Institutions Association organized Chinese experts focused on rosacea to develop a consensus based on the current status and advances in Chinese and international research. This consensus provides guidance on how clinicians can guide patients to correctly understand the disease, identify and reasonably avoid various triggers, receive standardized pharmacotherapy and laser/light therapies, and address psychological states and comorbidities. Additionally, expert recommendations were formulated through the Delphi method for clinical reference.

【Abstract】 Pyoderma gangrenosum （PG） is a rare neutrophilic dermatosis. Its most common clinical manifestation is the occult development of ulcers in normal or traumatized skin. PG is often associated with other systemic diseases. Early diagnosis and standardized treatment are crucial for managing PG and its associated comorbidities. Currently, there are no relevant diagnostic and therapeutic guidelines or consensus in China. Based on the latest Chinese and international research progress and international guidelines, the Chinese Society of Dermatology and the China Dermatologist Association organized experts in the relevant fields to develop this consensus using the Grading of Recommendations, Assessment, Development, and Evaluation （GRADE） approach and the Delphi method. This consensus focuses on the diagnostic criteria, severity assessment, and treatment strategies for PG, with the aim of providing guidance on the diagnosis, treatment, and long-term management of PG in China.

【Abstract】 Scabies is a common infectious dermatosis caused by Sarcoptes scabiei var. hominis, and mainly transmitted by direct skin contact. It occurs predominantly in children and the elderly. Clinically, it is divided into common scabies, crusted scabies, nodular scabies, bullous scabies, and nail scabies. Detection of scabies mites, eggs and fecal pellets on skin scraping is still the gold standard for the diagnosis of scabies, but several non-invasive techniques, such as dermoscopy, have become common methods. On dermoscopy, a dark-brown triangular structure （representing the anterior part of the mite） with its linear burrows, known as the “jet with contrail sign”, is pathognomonic for scabies. In 2020, the International Alliance for the Control of Scabies recommended three levels （confirmed scabies, clinical scabies and suspected scabies） of diagnostic certainty. Common scabies is usually treated with topical scabicides, of which permethrin is the first-line treatment, and benzyl benzoate and sulfur are the second line choice. A combined regimen of oral ivermectin with topical permethrin and keratolytics is the first-line therapy for crusted scabies.

【Abstract】 Psoriasis is a chronic, recurrent, inflammatory systemic disease that often coexists with various comorbidities, such as metabolic syndrome, cardiovascular diseases, diabetes, and psychiatric disorders, significantly impacting patients' physical and mental health. Proactively managing psoriasis comorbidities is of great importance for standardizing diagnostic and treatment pathways and improving clinical outcomes. Based on previous Chinese and international guidelines, clinical consensus, and the latest research advancements, this consensus systematically summarizes the management strategies for psoriasis with comorbidities, provides an in-depth elucidation of the treatment, prevention, and rehabilitation of psoriasis comorbidities, aiming to offer a scientific reference to healthcare professionals involved in psoriasis diagnosis and treatment in China.

【Abstract】 The interleukin-36 pathway plays an important role in the pathogenesis of various inflammatory skin diseases, including generalized pustular psoriasis （GPP）. Anti-interleukin-36R monoclonal antibodies, represented by spesolimab, provide more therapeutic options for GPP and other inflammatory skin diseases. The Chinese Society of Dermatology, the China Dermatologist Association, and other institutions convened experts in the relevant field to develop this consensus to provide recommendations on the indications, treatment regimens, and safety management of spesolimab in inflammatory skin diseases, such as GPP, localized pustular psoriasis, hidradenitis suppurativa, pyoderma gangrenosum, acute febrile neutrophilic dermatosis, and acute generalized exanthematous pustulosis, with the aim of guiding its clinical application. The application of spesolimab in special populations such as pediatric, pregnant, and elderly patients requires further clinical evidence. Future studies should focus on the long-term efficacy and safety of spesolimab in the treatment of GPP, and explore its potential in treating inflammatory skin diseases, particularly refractory neutrophilic dermatoses.

【Abstract】 Uncommon types of dermatophytoses have garnered increasing clinical attention. These conditions primarily include dermatophyte infections occurring in special populations （such as tinea capitis in adults, infants, and young children, as well as onychomycosis in minors）, infections involving special anatomical sites （such as tinea of vellus hair and genital dermatophytoses）, infections caused by uncommon or drug-resistant dermatophytes （e.g., Trichophyton indotineae）, and deep dermatophytoses associated with host immunocompromise or trauma （such as Majocchi′s granuloma, dermatophyte pseudomycetoma, and deep or disseminated dermatophytoses）. Clinically, these uncommon dermatophytoses often exhibit distinct characteristics in epidemiology, clinical manifestations, diagnosis, and treatment, are prone to misdiagnosis or delayed diagnosis, and remain treatment challenges due to the absence of standardized diagnostic and therapeutic protocols. To address these gaps, the Mycology Group of Chinese Dermatovenerology Society of Integrative Medicine and the Infection Group of Chinese Preventive Medicine Association Professional Committee on Prevention and Control of Dermatology and Sexually Transmitted Diseases convened a panel of experts to develop this expert consensus to address key issues regarding the epidemiology, clinical features, diagnosis, and treatment of these uncommon types of dermatophytoses, aiming to provide scientific and standardized guidance for clinical practice.

【Abstract】 Psoriasis is a chronic, recurrent, systemic, inflammatory disease. Over the past 20 years, with the development and application of biologics targeting tumor necrosis factor （TNF） or TNF receptors, interleukin-17A （IL-17A） or IL-17A receptors, IL-23, and others, significant progress has been made in the treatment of psoriasis. However, recurrence remains a major challenge in the management of psoriasis after discontinuation of biologic therapy or during maintenance treatment. This review summarizes the recurrence of psoriasis following biologic treatment and proposes comprehensive management recommendations to prevent its recurrence.

【Abstract】 Alopecia areata is a T cell-mediated autoimmune non-scarring hair loss disorder. Its core pathogenesis involves the collapse of immune privilege in hair follicles, which subsequently triggers CD8? T cell-mediated autoimmune responses and activates multiple inflammatory pathways, including Th1, Th2, Th17, and Treg pathways. Genetic susceptibility also contributes to disease development. Pediatric alopecia areata is highly heterogeneous. Earlier age at onset, particularly before 6 years of age, is associated with greater disease severity and higher recurrence rates, leading to a more substantial impact on the quality of life of affected children and their families. Pediatric alopecia areata should be differentiated from congenital and other acquired hair loss disorders in children. Currently, the management of pediatric alopecia areata faces challenges such as age restrictions for certain treatments and limited high-level evidence-based medical data. Therefore, stratified management based on age, disease stage, and severity is recommended. Based on the latest Chinese and international clinical guidelines and research evidence, as well as key clinical questions identified using the Delphi method, an expert panel was organized to develop this consensus after systematic evaluation and discussion. This consensus provides recommendations covering clinical classification, diagnostic pathways, assessment tools, and treatment strategies, aiming to promote the standardized diagnosis and treatment of pediatric alopecia areata in China and provide guidance for clinical practice.

【Abstract】 Diaper dermatitis is a common skin disease in infants and young children, which can cause discomfort, increase the care burden, and add to family stress. Currently, there is no evidence-based guideline on either traditional Chinese medicine or Western medicine for the prevention and treatment of diaper dermatitis in infants and young children. A multidisciplinary expert group was set up by the Professional Committee on Child Health and Drug Research of the Chinese Association of Traditional Chinese Medicine. Eleven clinical questions were identified through expert interviews and consensus conferences, in terms of risk factors, clinical manifestations, examinations, differential diagnoses, severity assessment, principles and goals of prevention and treatment, diagnosis and treatment strategies, and preventive measures. A systematic search was conducted for Chinese and English literature on the diagnosis, assessment, treatment, and prevention of diaper dermatitis in infants and young children, which was graded and evaluated using the Grading of Recommendations Assessment, Development and Evaluation system from the Oxford Centre for Evidence-Based Medicine. Recommendations were finalized through the Delphi and expert consensus methods. This guideline proposes a total of 17 recommendations and clarifies the timing and advantages of the traditional Chinese medicine and Western medicine interventions. This evidence-based guideline provides scientific recommendations on the prevention and treatment of diaper dermatitis in infants and young children using the integrated traditional Chinese and Western medicine interventions for healthcare providers （including practitioners of traditional Chinese medicine and Western medicine） at all levels of hospitals, as well as for the families of affected children.

【Abstract】 Moisturizer therapy is one of the fundamental treatments for atopic dermatitis. However, many challenges still exist in clinical practice despite its wide application. Based on Chinese and international guidelines, consensus, and clinical literature, and combined with expert clinical experience, an expert consensus on the rational use of moisturizers for atopic dermatitis was developed by a panel of Chinese experts convened by the Environmental and Occupational Skin Disease Research Group, Chinese Dermatovenerology Society of Integrative Medicine and other academic institutions. This consensus addresses key issues regarding the use of moisturizers in the management of atopic dermatitis, including the necessity of use, mechanisms of action, indications, contraindications, considerations during the application, selection principles, usage, dosage, and adverse reactions, aiming to provide guidance for the standardized application of moisturizers in clinical practice.

【Abstract】 Syphilis is a chronic systemic sexually transmitted disease caused by Treponema pallidum. With the sustained increase in the global incidence of syphilis, a rising trend in latent syphilis has also been observed. This review summarizes the research progress in the epidemiological characteristics, infectivity, pathogenesis, laboratory diagnosis, and treatment of latent syphilis.

【Abstract】 Photobiomodulation refers to the use of different non-ionizing light sources to exert non-photothermal effects on the regulation of cellular activity for therapeutic purposes. Photobiomodulation depends on the absorption of photons by molecular photoreceptors or intracellular chromophores, and monochromatic light at different wavelengths plays different regulatory roles in the skin. This review summarizes research progress in the mechanisms and clinical application of photobiomodulation in dermatology.

【Abstract】 The etiology and pathogenesis of melasma have not been fully elucidated. This article summarizes the recent research progress on melasma, explores the roles of photoaging, skin barrier dysfunction, mast cell activation, sex hormone fluctuations, and circadian rhythm disturbances in its pathogenesis, with the aim of providing new directions for its clinical prevention and treatment. With a deeper understanding of the pathogenesis of melasma, future therapeutic strategies are expected to shift from solely addressing skin pigmentation to comprehensive approaches involving anti-photoaging therapies and skin repair interventions.

【Abstract】 Objective To evaluate the clinical efficacy and safety of dupilumab in the treatment of endogenous hyperkeratotic hand-foot eczema. Methods Five patients with endogenous hyperkeratotic hand-foot eczema who showed inadequate response to conventional therapies were included in this case-series study and treated with dupilumab. Baseline scores before treatment were used as controls. During follow-up, treatment efficacy was quantitatively evaluated using the Hand Eczema Severity Index （HECSI）, and adverse events were recorded. Results Five patients with endogenous hyperkeratotic hand-foot eczema were included, aged 41 - 68 years, including 2 males and 3 females, with a disease duration ranging from 6 months to 40 years. For hand lesions, all five patients achieved HECSI50 at week 2, HECSI75 at week 12, and HECSI90 at week 20. For foot lesions, 4 patients achieved HECSI50 at week 4, and 4 patients achieved HECSI75 and HECSI90 at week 12. Conclusion Dupilumab could rapidly improve skin lesions in patients with endogenous hyperkeratotic hand-foot eczema who had an inadequate response to conventional therapies, with a favorable safety profile.

【Abstract】 The etiology and pathogenesis of melanoma are not fully elucidated. Recent studies have shown that circadian rhythm disruption can reconstruct the immune microenvironment of melanoma, and affect DNA repair, melanin synthesis and other processes, and may be an important step in the occurrence and development of melanoma. In addition, mutations in circadian clock genes can also increase the genetic susceptibility to melanoma. This review focuses on mechanisms underlying the regulation of circadian rhythm in the occurrence and development of melanoma, and new progress in melanoma treatment, providing a completely new perspective for the prevention and treatment of melanoma.

【Abstract】 Objective To investigate the clinical efficacy and safety of upadacitinib in the treatment of palmoplantar pustulosis that is refractory to or poorly controlled by conventional therapy and/or biological agents. Methods Clinical data were collected from 6 patients with palmoplantar pustulosis who were treated with upadacitinib at the outpatient department of Tianjin Medical University General Hospital from January 2023 to December 2023, and were retrospectively analyzed. Efficacy was evaluated by comparing the palmoplantar pustulosis area and severity index （PPPASI） scores and physician global assessment （PGA） scores in patients with palmoplantar pustulosis before and after the treatment. Adverse events were recorded during the treatment. Results Among the 6 patients with palmoplantar pustulosis, there was 1 male and 5 females, aged 47.22 ± 8.85 years. The patients were treated with oral upadacitinib at a dose of 15 mg/d or 30 mg/d. After 12 weeks of treatment and follow-up, the PPPASI scores decreased from 17.77 ± 10.34 points at baseline to 2.20 ± 1.73 points; the number of patients achieving PPPASI50, 75, 90 and 100 were 6, 6, 2 and 1, respectively, and 4 achieved PPPGA0/1. No severe adverse reactions occurred during the follow-up. Conclusion Upadacitinib may be a new option for refractory palmoplantar pustulosis, but its efficacy and safety still need to be evaluated in larger-sample studies.

【Abstract】 Biologic therapies have been successfully applied in the treatment of psoriasis and atopic dermatitis, however, unique phenomena of immunophenotypic switching have also been constantly reported. This review summarizes the current status and mechanisms of immunophenotypic switching among patients with psoriasis or atopic dermatitis during the treatment with biologics, in order to promote the full understanding of this new abnormal immune reaction.

【Abstract】 Melasma is an acquired pigmentation disorder with complex pathogenesis. In addition to the dysfunction of melanocytes, the imbalance of the microenvironment, particularly the multicellular interactions among keratinocytes, fibroblasts, vascular endothelial cells, mast cells, and sebocytes, also contributes to the progression of melasma. This review summarizes relevant research progress on melanocytes and their microenvironment in the pathogenesis of melasma, as well as advances in the treatment of melasma.

【Abstract】 Immune-mediated skin diseases refer to a group of disorders driven by immune dysfunction, leading to skin damage with or without involvement of other tissues or organs. They mainly include atopic dermatitis, psoriasis, alopecia areata, lupus erythematosus, Sj?gren's syndrome, etc. These diseases are characterized by complex pathogenesis, diverse clinical manifestations, and challenging treatment. Recent studies have increasingly confirmed that alterations in the composition and function of the gut microbiota are present in various immune-mediated skin diseases. Fecal microbiota transplantation （FMT） may restore the patients′ gut microenvironment and systemic immune balance by transplanting the gut microbiota from healthy donors into the patients′ gastrointestinal tract, and has become an important method for the treatment of immune-mediated skin diseases, but currently there is a lack of standardized guidelines on its clinical application. Therefore, based on the latest research advancements worldwide and evidence-based medical studies, the “guidelines for fecal microbiota transplantation in the treatment of immune-mediated skin diseases （2025 edition）” has been formulated. This guideline addresses specific issues faced by dermatologists in China regarding the clinical application of FMT, and provides scientific and detailed evidence-based recommendations, aiming to promote the standardization of FMT therapy.

【Abstract】 Stem cells are a kind of cells with the ability of self-renewal and differentiation, which can differentiate into melanocytes to fill the areas of pigment loss in damaged skin, fight against the apoptosis of melanocytes caused by autoimmunity and oxidative stress damage, and improve repigmentation rates in combination with traditional therapies. Studies have shown significant efficacy of stem cell therapy in the repigmentation of vitiligo. This review summarizes the latest advances in the basic and clinical research on the application of stem cells in the treatment of vitiligo.

【Abstract】 Atopic dermatitis is a chronic relapsing inflammatory dermatosis with heterogeneity at different body sites. Atopic dermatitis of the head and neck has received increasing attention as a special-site subtype. This review summarizes the research progress in atopic dermatitis of the head and neck from the aspects of etiology and pathogenesis, clinical manifestations, auxiliary examinations, diagnosis and differential diagnosis, as well as treatment and management, aiming to provide new ideas for its clinical diagnosis and treatment.

【Abstract】 Objective To evaluate the efficacy and safety of ruxolitinib phosphate 1.5% cream in the treatment of 5 cases of nonsegmental vitiligo. Methods A case series study was conducted. Five patients with nonsegmental vitiligo were collected from the Boao Super Hospital between August 2023 and April 2024. All the patients were treated with topical ruxolitinib phosphate 1.5% cream alone twice daily. Efficacy was assessed at weeks 12 and 24 using the Facial Vitiligo Area Scoring Index （F-VASI） and the Total Vitiligo Area Scoring Index （T-VASI）. During the treatment, adverse reactions were monitored. Results The 5 patients were aged 28 - 43 years, with the disease duration ranging from 4 to 30 years. Lesions involved both facial and non-facial areas, with the affected body surface area ranging from 2.6% to 6.9%. After 12 weeks of treatment, 3 patients achieved 75% improvement in facial lesions （F-VASI 75）, and 2 achieved T-VASI 50. After 24 weeks of treatment, all patients achieved F-VASI 50, including 3 achieving F-VASI 90 and 2 achieving T-VASI 50. During the treatment, adverse reactions included application-site acne （1 case）, application-site exfoliation （2 cases）, and application-site pruritus （2 cases）; none of these adverse reactions affected the treatment. Conclusion Ruxolitinib phosphate 1.5% cream may serve as a treatment option for nonsegmental vitiligo.

【Abstract】 Systemic lupus erythematosus is a complex autoimmune disease predominantly affecting young women, and can involve multiple organs and systems. In 2024, significant advancements have been made in the research on systemic lupus erythematosus, particularly in the aspects of pathogenesis and treatment. This review summarizes the major progress achieved in these aspects.

【Abstract】 Objective To investigate clinical features and non-invasive skin imaging findings of acquired facial hyperpigmented macules in children. Methods A retrospective analysis was conducted on the clinical characteristics of children with acquired facial hyperpigmented macules diagnosed in the Outpatient Department of Dermatology, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology from January 2020 to June 2023. Reflectance confocal microscopy and dermoscopy were performed to observe lesions and perilesional normal skin, and summarize the imaging findings. Results A total of 131 children with acquired facial hyperpigmented macules were collected, including 88 males and 43 females; their ages ranged from 2 to 25 months, the age at onset was 11.50 ± 7.15 months, and the disease duration was 6.50 ± 4.66 months. The lesions were distributed in the temporal and/or frontal regions, mostly measuring 4 to 10 mm in length, and they mainly manifested as non-confluent irregular brown or brownish-red hyperpigmented macules, without scales on the surface. The total number of lesions was less than 10 in 19 cases （14.50%）, between 10 and 20 in 75 cases （57.25%）, and more than 20 in 37 cases （28.24%）. Reflectance confocal microscopy revealed no elongation of the rete ridges, but mild increased pigmentation in the basal layer, slight vascular dilatation in the dermal papilla and superficial dermis, and scattered melanophages and inflammatory cell infiltration in some lesions. Dermoscopy showed pigment networks with varying color darkness, which were distributed along the dermatoglyphs, and mixed with linear or punctate vessels. Conclusions Acquired facial hyperpigmented macules is a common skin disease occurring in infants and young children, and is characterized by typical lesions by reflectance confocal microscopy and dermoscopy. Histopathological examination may be unnecessary for its diagnosis, and skin imaging techniques can help improve diagnostic accuracy.

【Abstract】 With the deepening understanding of the pathogenesis of psoriasis, small-molecule drugs targeting the key Janus kinase （JAK）-tyrosine kinase （TYK）2 pathway have gained increasing interest. TYK2-related pathways play an important role in the pathogenesis of psoriasis, while they are not involved in modulating broad biological effects, making them one of the potential therapeutic targets for the efficient and safe treatment of psoriasis. How to improve the selectivity and specificity of TYK2 inhibitors to minimize adverse reactions associated with the inhibition of other pathways has been one of the key directions for development of drugs targeting TYK2 in recent years. This review summarizes the role of TYK2 pathway in the pathogenesis of psoriasis, the modes of action of TYK2 inhibitors （competitive or allosteric inhibition）, and the latest clinical research progress.

【Abstract】 Objective To investigate postoperative complications in and prognosis of patients with axillary osmidrosis after minimally invasive rotary cutting surgery. Methods Clinical data were retrospectively collected from patients with axillary osmidrosis who underwent minimally invasive rotary cutting surgery in the Department of Burn and Plastic Surgery, the Second Affiliated Hospital of Hengyang Medical College, University of South China from January 2012 to January 2022. Clinical efficacy was analyzed, and postoperative complications were investigated. Types of postoperative complications, as well as targeted prevention and treatment methods and follow-up outcomes, were recorded. Results A total of 3 000 patients with axillary osmidrosis （6 000 axillae） were included, comprising 1 180 males and 1 820 females. They were aged 18 - 40 years, with an average age of 25 years. The surgical duration was 30 - 60 minutes, with an average of 48 minutes. During 1 year of follow-up, 5 640 affected axillae （94%） were cured, 360 axillae （6%） were markedly improved, and none of the axillae showed no response. Postoperative complications included local hematoma in 360 axillae, skin folds in 37 axillae, epidermal abrasion in 370 axillae, skin necrosis in 10 axillae, and hypertrophic scars in 5 axillae. Early removal of hematoma, mechanical stretching of folded skin, enhanced dressing changes for abraded and necrotic skin, and anti-scar treatment with fractional laser, etc., were performed for the aforementioned complications, and all of the complications were relieved. Conclusions The overall incidence rate of postoperative complications was about 13% in patients with axillary osmidrosis after minimally invasive rotary cutting surgery. Strengthening the control of intraoperative details and postoperative care education could help effectively avoid the occurrence of related complications.

【Abstract】 Pyogenic arthritis, pyoderma gangrenosum and acne （PAPA） syndrome is an autosomal dominant inherited autoinflammatory disease. Its diagnosis and treatment are challenging due to the complexity of pathogenesis and diversity of clinical manifestations. In this article, a 28-year-old male patient with PAPA syndrome was reported, who presented with inflammatory papules, nodules, and cysts on the face for 6 years and repeated painful ulcers on the lower extremities for 3 years. The patient had a history of aseptic pyogenic arthritis. Histopathological findings of lower extremity lesions indicated neutrophil infiltration, and whole-exome sequencing indicated a heterozygous missense mutation c.748G>A （p.Glu250Lys） in exon 11 of the PSTPIP1 gene. The patient was finally diagnosed with PAPA syndrome. After successive treatment with glucocorticoids, cyclosporine, minocycline, and other drugs, the lesions improved, but were recurrent. Afterwards, the patient received 3-month treatment with adalimumab combined with glucocorticoids, the ulcerative skin lesions on the lower extremities markedly improved, and the facial lesions gradually subsided; the treatment lasted 1 year, and the patient′s condition was stable without recurrence.

【Abstract】 Collagen plays a significant role in the prevention and treatment of facial skin aging. With the increasing demand for rejuvenation among beauty seekers, medical recombinant humanized collagens have attracted much attention due to their characteristics of high safety and biological activity. To better standardize and guide the application of medical recombinant humanized collagens in facial rejuvenation, the expert panel from the Society of Aesthetic Dermatology of Chinese Association of Plastics and Aesthetics and the Dermatology Committee of Chinese Non-government Medical Institutions Association formulated this expert recommendation after joint discussion. The recommendation includes the definition, classification, mechanisms of action, and clinical application (either alone or in combination with other techniques) of recombinant humanized collagens in facial rejuvenation, as well as the management of related adverse reactions and factors influencing therapeutic efficacy, with the aim of providing guidance for the standardized management of their clinical applications.

【Abstract】 Objective To investigate the efficacy and safety of lanadelumab in the treatment of hereditary angioedema. Methods Databases including PubMed, Embase, Cochrane Library, CNKI, Wanfang data and Sinomed were searched from the inception of the databases to November 9, 2022 for clinical trials of lanadelumab in the treatment of hereditary angioedema. The primary outcome was the number of disease episodes during treatment, and the secondary outcomes were plasma high-molecular-weight kininogen levels and patient quality of life scores. Safety evaluation indicators were incidence rates of adverse events. Results A total of 6 clinical studies were included, including 3 randomized controlled trials and 3 observational studies. Among them, 4 studies showed a significant decrease in the number of monthly attacks in patients with hereditary angioedema after the treatment with lanadelumab; 2 studies showed a significant inhibition in the cleavage of plasma high-molecular-weight kininogen after lanadelumab treatment; 4 studies showed a noticeable improvement in the patient quality of life after treatment. None of the 6 studies reported serious treatment-related adverse events. Common adverse events were headaches and injection site reactions, which were generally controllable. Conclusion Lanadelumab is a biological agent with good efficacy and safety, which can be used for the long-term prevention of hereditary angioedema attacks.

【Abstract】 With the accelerating pace of population aging, the clinical management of psoriasis in the elderly is facing new challenges and opportunities. As an immune-mediated chronic inflammatory systemic disease, psoriasis in the elderly is characterized by a prolonged disease course, complex comorbidities, and increased treatment difficulty. To standardize the clinical diagnosis, treatment, and rehabilitation management of psoriasis in the elderly, the Chinese Association of Rehabilitation Dermatology and the Combination of Traditional and Western Medicine Dermatology convened experts in related fields to develop the “Expert consensus on the diagnosis, treatment and rehabilitation of psoriasis in the elderly （2026 edition）”, drawing on the latest clinical research evidence and advances in evidence-based medicine. This consensus focuses on providing practical recommendations on key aspects of geriatric psoriasis management, including disease assessment, individualized treatment strategies, coordinated management of comorbidities, medication safety monitoring, and rehabilitation interventions. The aim is to enhance clinicians' capacity for comprehensive management of psoriasis in the elderly, improve clinical outcomes, and ultimately elevate patients' quality of life.

【Abstract】 Several studies have indicated that pharyngeal and intestinal microflora, as well as their metabolic products, are involved in the occurrence and development of as well as immunoregulation in psoriasis by activating T lymphocytes, dendritic cells and keratinocytes. This review summarizes current research progress in the correlation of pharyngeal and intestinal microbes with the pathogenesis of psoriasis.

【Abstract】 Atopic dermatitis （AD） is a common chronic inflammatory skin disease with unclear pathogenesis. Multiple inflammatory cells and relevant cytokines are involved in its occurrence. Janus kinase（JAK） inhibitors can suppress the JAK-signal transducer and activator of transcription signaling pathway, block the signal transduction of relevant cytokines, and alleviate inflammatory responses.Several JAK inhibitors have been approved for the treatment of moderate-to-severe AD, and clinical trials have demonstrated their good efficacy and safety. This review summarizes the mechanisms of action, efficacy and safety of different types of JAK inhibitors for the treatment of moderate-to-severe AD.