Objective To study the effect of cigarette smoke extract(CSE) on the proliferation and growth of primarily cultured skin fibroblasts.Methods Fibroblasts were isolated from the foreskin of healthy young adults,and subjected to primary culture.After 5～15 passages,these fibroblasts were exposed to various concentrations of CSE for various durations.MTT assay was used to detect the viability of fibroblasts after exposure.The morphological and structural changes of these cells were observed by microscopy. β-galactosidase staining was performed on fibroblasts treated with CSE during several passages.Growth curves were drawn with MTT method for fibroblasts exposed to low concentration of CSE during 5 passages.The content of reactive oxygen species(ROS) in cell plasma,and activities of superoxide dismutase(SOD) in cells were determined by spectrophotometric method.Results The fibroblasts displayed typical morphological changes after exposed to CSE for 24 h.The viability of fibroblasts declined with the increase of CSE concentration and treatment time. β-galactosidase was detected more frequently in fibroblasts exposed to CSE during 5 passages than in those without any treatment.After CSE treatment,the content of ROS significantly increased,while the activities of SOD decreased(both P<0.05).Conclusions These findings suggest that CSE could injure cultured fibroblasts and inhibit the growth and proliferation of them.Furthermore, long-term action of CSE at low concentration could accelerate the senescence of primarily cultured fibroblasts,and oxidative damage may be involved in the CSE injury to cells.

Objective To investigate the role of BRAF^V600E in the development of melanoma,as well as in vivo and in vitro suppression of BRAF^V600E by short hairpin RNA(shRNA).Methods Previously constructed shRNAs targeted against the BRAF gene were used.Three plasmids,including two BRAF-specific shRNA plasmids,braf 1 and braf 2,and a negative control plasmid,were constructed and transfected into human melanoma cell line A375.A xenograft nude mouse model was used to examine the inhibitory effect ofshRNA in vivo.The expressions ofBRAF mRNA and protein were detected by RT-PCR and Western blotting,respectively.Results The specific shRNA inhibited the in vivo and in vitro expression of BRAF mRNA and protein;protein level was decreased by 62% in vivo and 90%/n vitro.In the mouse model,the tumorigenicity was decreased by the specific shRNA and the growth of tumor was inhibited by 62%.Conclusion The specific shRNAs suppress the mRNA and protein expression of BRAF^V600E,and this gene may play an important role in the development of melanoma.

Objective To investigate the effect of BRAFV600E mutation on the invasion capacity of a human melanoma cell line, A375. Methods Plasmids containing short hairpin RNAs （shRNA） specific for BRAF gene were prepared in previous study, and used to transfect A375 cells. Those cells transfected with negative plasmid and untransfected cells served as the controls. Transwell chambers were used to examine the invasion ability of melanoma cells in vitro. RT-PCR and Western blotting were performed to detect the mRNA and protein expressions of matrix metalloproteinase 2 （MMP-2） and vascular endothelial growth factor （VEGF）, respectively, before and after the transfection. The activity of MMP-2 was also studied with sodium dodecyl sulfate polyacrylamide gel electrophoresis （SDS-PAGE）. Results Compared with the negative control, the specific shRNA decreased the mRNA and protein expressions of MMP-2 by 35% and 85%, respectively, and those of VEGF by 45% and 14%, respectively. Additionally, the number of cells invading through Matrigel chambers reduced by 69% in those cells transfected with the positive plasmid. Conclusions The mutant BRAFV600E has the potential to enhance the invasion capacity of melanoma cells, whereas specific shRNA could suppress the increase in metastasis capacity likely by inhibiting the production of VEGF and MMP.

ABSTRACT】Objective To investigate the role of Akt/ mTOR signal pathway in the pathogenesis of basal cell carcinoma by observing the expressions of Akt and mTOR in basal cell carcinoma，and their clinical significances. Methods Immunohistochemical method was applied to detect the expressions of　Akt and mTOR in skin specimens including 37 cases of basal cell carcinoma and 16 cases of normal skin. Results The rate of positive expression of Akt in basal cell carcinoma and normal skin tissue were 62.2%,12.5% respectively. The rate of positive expression of mTOR in basal cell carcinoma and normal skin tissue were 83.8%, 37.5% respectively. There were significant differences between normal skin tissues and basal cell carcinoma in the expression of Akt and mTOR (P<0.05). There were significantly positive correlation between the expression of Akt and mTOR in basal cell carcinoma. Conclusion Akt/mTOR signal pathway may play an important role in the pathogenesis of basal cell carcinoma.

【Abstract】 Urticaria is a common skin disease characterized by wheals and pruritus, and some refractory cases showed prolonged duration and poor response to treatment. This guideline is a refinement of the previous version of the guideline for diagnosis and treatment of urticaria in China （2018）, and is developed by dozens of experts from Centre for Urticaria Research, Chinese Society of Dermatology after joint discussions on the basis of recent clinical and investigational advances in urticaria in China and other countries. This guideline is suitable for both Chinese adults and children with urticaria. In addition to supplementing and updating the definition and pathogenesis of urticaria, the guideline also provides detailed explanations about key concerns in clinical practicethe, such as the classification, diagnosis and treatment of urticaria, in the form of questions and answers. The guideline may provide a more comprehensive, scientific and authoritative reference for diagnosis and management of urticaria.

【Abstract】 Chronic inducible urticaria is a group of chronic urticaria induced by specific triggers, with wheal and/or angioedema as main clinical manifestations, which may be accompanied by itching, tingling, burning sensation, pain and other unpleasant symptoms. This group of diseases are characterized by highly heterogeneous clinical manifestations, long courses, and recurrent symptoms, which have a great impact on the quality of life of patients. Based on progress in Chinese and international clinical studies on the diagnosis and treatment of chronic inducible urticaria in recent years, the Immunology Group of Chinese Society of Dermatology extensively consulted experts through the Delphi method, and finally developed this consensus after several rounds of discussion among relevant experts, in order to improve clinicians' understanding of this group of diseases and standardize their diagnosis and treatment.

Wu Haien, Liu Yongbin, Shan Yunhui, Yang Yafang, Wang Ying, Ma Tianqi, Qin Peng, Cui Liang, Yao Fang, Jin Chunlin, Li Tienan Department of Dermatology, Shenyang No.7 People′s Hospital, Shenyang 110003, China Corresponding author: Liu Yongbin, Email: syqyybin@126.com 【Abstract】 Objective To investigate the efficacy and safety of 308-nm excimer laser compared to high-intensity ultraviolet radiation for the treatment of active localized vitiligo, and to observe changes in skin lesions before and after the treatment by confocal laser scanning microscopy. Methods Sixty patients with 203 skin lesions of active localized vitiligo and were enrolled into this study, and the vitiligo disease activity （VIDA） score of these patients ranged from 2 to 3. We selected more than 3 skin lesions from a same anatomical site of each patient, one of lesions served as a control and the other skin lesions （≥ 2） were randomly treated with 308-nm excimer laser （laser group） or high-intensity ultraviolet radiation （ultraviolet group）. The treatment was conducted twice a week for 25 sessions, and a 3-month follow-up was performed. Results A total of 48 patients with 169 skin lesions completed the trial. The marked response rate was significantly higher in the laser group ［66.15%（43/65）］ than in the ultraviolet group ［44.64%（25/56）, χ2 = 8.28, P < 0.01］. The patients with a VIDA score of 2 showed a significantly higher marked response rate ［67.69%（44/65）］ compared with those with a VIDA score of 3 ［44.64%（25/56）, χ2 = 6.80, P < 0.01］. During the 3-month follow-up, no relapse was observed. Confocal laser scanning microscopy showed that the number of inflammatory cells increased at the dermal-epidermal junction of the intra- and extra-marginal lesional skin. After treatment, the number of inflammatory cells markedly decreased and returned to normal level in lesions. Conclusion Both 308-nm excimer laser and high-intensity ultraviolet radiation are effective in the treatment of active localized vitiligo, but the 308-nm excimer laser shows a more rapid onset of action and a better therapeutic effect.

【Abstract】 Objective To investigate clinical features of patients with chronic spontaneous urticaria （CSU） in China. Methods A questionnaire survey was carried out in CSU patients at the first visit and 4 follow-up visits in Departments of Dermatology of 12 third-grade hospitals in northern and southern China from January to December 2019. The survey content included demographic characteristics, pruritus intensity, the number of wheals, concomitant symptoms （such as pain in skin lesions, arthralgia, fever） during the last week prior to the admission, classification and subtypes of urticaria, and previous and current treatment regimens, etc., and the 7-day urticaria activity score （UAS7） was used to evaluate the therapeutic effect. Patients from 9 hospitals in Sichuan, Hubei and Fujian provinces were enrolled into the southern China group, and patients from 3 hospitals in Beijing municipality and Liaoning province were enrolled into the northern China group. Differences between groups were analyzed by two-independent-sample t-test, Mann-Whitney U test or chi-square test. Results Overall, 1 396 CSU outpatients were enrolled, including 592 males and 804 females; their age was 38.32 ± 16.13 years, 1 109 （79.5%） were aged between 20 and 60 years, and 660 （47.3%） were aged between 20 and 40 years. Their age at onset was 35.85 ± 16.03 years, and the disease duration was 0.50 （0.25, 2.00） years. Allergic diseases were the most common concomitant diseases, 269 （19.3%） patients were diagnosed with accompanied allergic rhinitis or conjunctivitis, 169 （14%） with accompanied eczema/dermatitis, 39 （2.8%） with accompanied asthma; only 19 （1.4%） CSU patients had a history of thyroid diseases, but 133 （9.5%） were positive for anti-thyroid peroxidase （TPO） or anti-thyroglobulin （Tg） antibodies at the visit; elevated serum total IgE levels were observed in 437 （31.3%） patients, and 104 （7.4%） were positive for autoantibodies. There were 1 078 （77.2%） patients in the southern China group and 318 （22.8%） in the northern China group, and the southern China group showed significantly longer disease duration （2.16 ± 4.76 years vs. 1.53 ± 2.80 years, P < 0.001）, and significantly higher proportions of patients with family history （10.7% vs. 3.5%）, with painful lesions （5.8% vs. 0.9%）, and those with arthralgia （10.7% vs. 0） compared with the northern China group （all P < 0.05）. The three most prevalent urticaria subtypes were CSU （835 cases, 49.9%）, symptomatic dermographism （437 cases, 31.3%）, and angioedema （138 cases, 9.9%）, and the proportion of patients with the single diagnosis of CSU was significantly higher in the southern China group （53%） than in the northern China group （38.9%, P < 0.001）. In terms of treatment, 1 365 （97.8%） patients received conventional-dose second-generation H1 antihistamines alone or in combination, and only 31 （2.2%） were treated with antihistamines at high doses; other medicines were mostly administered in combination, and compound glycyrrhizin was most frequently prescribed （36.6%）, while omalizumab was only administered in 7 patients （0.5%）. Conclusions Significant differences in the clinical features of CSU were observed between northern and southern China. Nowadays traditional modalities are inadequate for the treatment of CSU, and new therapeutic drugs are somewhat promising.

【Abstract】 Chemical peeling is widely used for the treatment of a variety of skin diseases and skin photoaging. Its rational, effective and safe application has become a matter of concern in clinical practice. To standardize the clinical application of chemical peeling, an expert group developed this consensus based on the latest research achievements and extensive discussions. This consensus provides specific guidance for clinicians from the aspects of definition and classification, mechanisms of action, indications and contraindications of, techniques for and adverse reactions due to chemical peeling, as well as considerations during its application.

【Abstract】 Atopic dermatitis is a common disease characterized by recurrent chronic eczematous lesions, accompanied with dry skin and pruritus. With the changes of life style and living environment, the prevalence of atopic dermatitis in China has been increased during the past decade. AD affects all age groups. This guideline is the revision of guideline for diagnosis and treatment of atopic dermatitis in China （2014）, and is based on advances on atopic dermatitis in recent 5 years. This guideline updates and elaborates the definition, prevalence, pathogenesis, classification, diagnosis, prevention and treatment of atopic dermatitis, and provides a scientific and authoritative reference for diagnosis and management of atopic dermatitis.

【Abstract】 Chronic spontaneous urticaria （CSU） is the most common phenotype of chronic urticaria. Liscenced-dosed, up-dosed, or combined second-generation H1-antihistamines are choices for the treatment of CSU. However, approximately 50% of patients with CSU are resistant to antihistamine therapies. The treat-to-target approach has been proven to improve the quality of chronic disease management, but has not been proposed in CSU in China so far. Based on the latest guidelines, consensus, clinical trials and real-world studies in China and other countries, and combined with experts′ clinical experience, 31 Chinese experts in the field of urticaria diagnosis and treatment and related fields developed this consensus on treat-to-target in CSU, aiming to provide detailed guidance to clinicians.

【Abstract】 Dermatomyositis, a type of idiopathic inflammatory myopathies, is characterized by characteristic skin manifestations, proximal muscle weakness, and multiple organ involvement, which can also be accompanied by malignancies. Based on Chinese and international literature and expert advice on the diagnosis and treatment of adult dermatomyositis, experts from the Dermatology Branch of China International Exchange and Promotive Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis, which can provide a reference for dermatologists and clinicians from other relevant departments in clinical practice.

【Abstract】 Eczema and dermatitis are very common diseases in dermatology. It is believed that they are dominant diseases for integrated traditional Chinese and Western medicine treatment, and many Western medicines and traditional Chinese medicines have been widely used in the treatment of these diseases. In order to ensure the rational application of these medicines, relevant experts developed this consensus on integrated traditional Chinese and Western medicine for eczema and dermatitis based on recent Chinese and international guidelines, consensus, and reported clinical studies, as well as personal clinical experience, aiming to standardize their application, improve efficacy and safety, and provide guidance for dermatologists in clinical practice.

【Abstract】 Atopic dermatitis in the elderly （> 60 years old） differs from that in children and adults in terms of demographical characteristics, pathogenesis, clinical manifestations and complications, and special considerations are needed for its diagnosis and treatment. Thus, the Immunology Group of the Chinese Society of Dermatology developed an expert consensus on the diagnosis and treatment of atopic dermatitis in the elderly, aiming to standardize and guide the effective management of elderly patients with atopic dermatitis.

【Abstract】 Atopic dermatitis is a chronic inflammatory skin disease, characterized by eczematous dermatitis and severe pruritus, and has severe impact on patients′ quality of life. Patients with moderate to severe atopic dermatitis often require systemic treatments, but traditional systemic treatments are ineffective or intolerable in some patients. In recent years, several biological agents have been applied to the treatment of atopic dermatitis in clinical practice, among which the interleukin-4 receptor antagonist dupilumab has been marketed in China. Some experts in related fields from Working Group for Atopic Dermatitis, Chinese Society of Dermatology and Working Group for Children′s Diseases, Chinese Society of Dermatology discussed the application of dupilumab in the treatment of moderate to severe atopic dermatitis, and developed a consensus, in the hope of providing a reference for the clinical application of dupilumab in the treatment of atopic dermatitis.

【Abstract】 Chronic pruritus is a common symptom of various diseases, causing severe negative impacts on patients′ quality of life. Due to its complex pathogenesis, etiological diagnosis and treatment are often challenging. To improve the understanding of chronic pruritus among Chinese clinicians and to standardize diagnosis and therapeutic practices, the China Dermatologist Association organized experts in China to update the classification, etiology, and pathogenesis of chronic pruritus based on the "Guidelines for the Management of Chronic Pruritus （2018 edition）" , current research status and progress in China and other countries, as well as extensive consultation with experts in China through the Delphi method, aiming to provide expert opinions and evidence-based medical guidance on the etiological diagnosis and treatment of chronic pruritus.

【Abstract】 The application of moisturizers and emollients is an important method for protecting or repairing skin barriers, maintaining skin health, and coping with skin diseases. In order to standardize and rationalize the application of moisturizers and emollients, the China Dermatologist Association convened Chinese experts in this field to conduct sessions of in-depth discussions based on up-to-date Chinese and international research outcomes, and reached a consensus on the efficacy, composition selection, application indications, application methods and adverse reactions of moisturizers and emollients, as well as considerations during their use.

【Abstract】 Rosacea, a chronic inflammatory skin disease primarily affecting central areas of the face, mainly manifests as recurrent flushing and erythema on the central face. In recent years, there has been progress in the understanding of its diagnosis and treatment. To this end, some experts were organized to establish this guideline on the basis of “diagnosis and treatment of rosacea in China: an expert consensus statement （2016）”. The new guideline proposes diagnostic criteria for rosacea at different sites, aiming to further standardize the diagnosis and treatment of rosacea in China.

【Abstract】 In order to promote the understanding of chronic urticaria among dermatologists and primary healthcare workers, to popularize the knowledge of the disease for patients, and to provide scientific suggestions on medication and life management for patients, the Centre for Urticaria Research of Chinese Society of Dermatology and Group on Allergic Diseases of China Dermatologist Association organized some experts to screen out 15 common questions related to chronic urticaria after collective discussion, involving definition, etiology, related examinations, treatment options of chronic urticaria and considerations during medication, and give professional answers to these questions. This guideline is formulated in a question-and-answer format, with a view to providing guidance on education of patients with chronic urticaria for dermatologists.

【Abstract】 Mycosis fungoides, the most common type of cutaneous T-cell lymphoma, usually only involves the skin at the early stage, and progresses into tumors with involvement of lymph nodes, peripheral blood and the viscera at the advanced stage. A comprehensive stage evaluation should be performed before the initiation of the treatment, and treatment decisions are determined according to the disease stage. Based on the latest international guidelines and consensus, as well as a review of evidence-based treatment options, and combined with current treatment status in China, 12 Chinese experts in the field of diagnosis and treatment of mycosis fungoides established this consensus, with an emphasis on first-line and second-line treatment options and novel therapies for mycosis fungoides, so as to provide guidance for standardizing the treatment of mycosis fungoides.

【Abstract】 Wet-wrap therapy has been applied to the treatment of atopic dermatitis and proved to be safe and effective. Attention has been paid to the appropriate, effective and safe use of wet-wrap therapy in clinical practice. To this end, a group of Chinese experts majoring in dermatitis and eczema developed this consensus after thorough discussions based on Chinese and international research data，current clinical experience, and characteristics of Chinese patients. This consensus focuses on the mechanism of action, indications and contraindications, application methods, efficacy and safety of wet-wrap therapy, as well as its use in special populations and home-based wet-wrap therapy.

【Abstract】 Cyclosporine, a kind of calcineurin inhibitor, is a potent non-cytotoxic immunosuppressant. It mainly acts on T lymphocytes and exerts an immunosuppressive effect by inhibiting T lymphocyte proliferation and cytokine transcription. Cyclosporine is commonly used in the treatment of psoriasis and atopic dermatitis in dermatology, and has also been reported for the treatment of systemic lupus erythematosus, dermatomyositis, vasculitis and other diseases. Based on Chinese and international literature （mainly including randomized controlled clinical trials, expert consensus or proposals）on cyclosporine in the treatment of immune-related skin diseases, relevant Chinese experts developed a proposal on cyclosporine in the treatment of immune-related skin diseases after repeated discussions.

【Abstract】 Cutaneous adverse reactions are common during anti-tumor therapy, which not only greatly affect patients′ quality of life, but may also cause discontinuation and dose reduction of anti-tumor therapy. With the increasing diversity of anti-tumor drugs, cutaneous adverse reactions have become more complex and challenging for clinicians. In view of this, the Shanghai Society of Dermatology and Venereology and Shanghai Society of Target Molecular Oncology, Shanghai Medical Association organized experts to discuss and sort out existing relevant clinical evidence to develop an expert consensus. This consensus summarizes cutaneous adverse reactions to anti-tumor drugs, such as cytotoxic chemotherapy drugs, molecular targeted drugs, and immune checkpoint inhibitors, and proposes prevention and management measures for common cutaneous adverse reactions, aiming to provide standardized guidance for clinicians and nurses in the fields of oncology and dermatology in clinical practice.

Syphilis, gonorrhea and genital Chlamydia trachomatis infection are main sexually transmitted diseases which need focused prevention and treatment in China. Clinical manifestations of syphilis are complicated. According to its duration of onset, clinical features, and transmission routes, syphilis can be classified as primary syphilis, secondary syphilis, tertiary syphilis, neurosyphilis, latent syphilis and congenital syphilis. Gonorrhea and genital Chlamydia trachomatis infection mainly affect genitourinary tract, and their clinical manifestations markedly vary from asymptomatic types to complicated types. Diagnosis of the 3 diseases should be based on their epidemiological history, clinical manifestations and laboratory examination results. Treatment should be started according to recommended regimens as early as possible. Appropriate follow-up should be performed after treatment. The antimicrobial resistance in gonorrhea has become a clinical concern.

【Abstract】 At present, exact pathogenesis of melasma remains unclear, genetics, sunlight exposure, sex hormones, etc., are considered as the main causative factors. Its pathogenesis involves excessive melanin synthesis, vascular hyperplasia in skin lesions, inflammation and skin barrier impairment. The diagnosis of melasma mainly relies on clinical manifestations and non-invasive detection techniques. Based on research progress in recent years, this consensus comprehensively elaborates the etiology, pathogenesis, clinical manifestations, staging and classification, diagnosis and treatment of melasma, aiming to improve the diagnosis and treatment of melasma by Chinese dermatologists.

【Abstract】 Psoriasis is an immune-mediated chronic, recurrent, inflammatory, systemic disease induced by the interaction between the individual and environment. Psoriasis is a non-communicable disease, its typical clinical manifestations are locally or widely distributed scaly erythema or plaques. The etiology of psoriasis involves heredity, immunity, environment, and other factors. Until now, psoriasis is still an incurable disease. Choosing appropriate drugs and regimens is very important for patients with psoriasis to control the condition, reduce comorbidities, maintain long-term efficacy, and comprehensively improve the quality of life. To standardize the diagnosis and treatment procedure of psoriasis, improve treatment effectiveness, and minimize adverse reactions, the Committee on Psoriasis of Chinese Society of Dermatology formulated this guideline based on the "Guideline for the diagnosis and treatment of psoriasis in China （2018 complete edition）" and according to the current situation in China, with some contents supplemented and revised in this guideline. Because latest research achievements in traditional Chinese medicine for the diagnosis and treatment of psoriasis were combined, this guideline was also an integrated Chinese and Western medicine guideline for the diagnosis and treatment of psoriasis. Considering the complexity of psoriasis, the treatment regimens should be decided according to patients′ individual situation. Topical treatment is commonly recommended for patients with mild psoriasis, systemic treatment can be chosen for those with moderate to severe psoriasis, and biological agents or small-molecule drugs can be selected for those with poor response to traditional systemic treatment.

Health professions preventing and controlling coronavirus disease 2019 are prone to skin and mucous membrane injuries, which may cause acute and chronic dermatitis, secondary infections and aggravation of underlying skin diseases. This is a consensus of Chinese experts on measures and advice on hand cleaning? and medical glove?related hand protection, mask?and goggles?related face protection, ultraviolet?related protection, as well as eye, nasal and oral mucosa, outer ear and hair protection. It is necessary to strictly follow standards on wearing protective equipments and specifications on sterilizing and cleaning. Both insufficient and excessive protection will adversely affect the skin and mucous membrane barrier. At the same time, using moisturizing products is highly recommended to achieve better protection.

【Abstract】 Psoriasis is an immune-mediated chronic, recurrent, inflammatory, systemic disease induced by the combination of heredity and environment. Psoriasis is a non-communicable disease, its typical clinical manifestations are limited or widely distributed scaly erythema or plaques. Its treatment is difficult, and patients usually need lifelong treatment. The etiology of psoriasis involves heredity, immunity, environment and other factors, which may induce excessive proliferation of keratinocytes or inflammation of joint synovial cells and chondrocytes via the immune response mainly mediated by T lymphocytes and various immune cells. In the theory of traditional Chinese medicine （TCM）, it is believed that psoriasis is mostly caused by hot toxic blood, loss of nutritional ingredient in blood, blood perfusion stasis, dry wicked wind in the body and skin system imbalance. Psoriasis is an incurable disease, and many drugs and regimens are available for its treatment at present. Choosing appropriate drugs and regimens is very important for patients with psoriasis to control disease progression and maintain long-term efficacy. The purpose of guidelines is to gradually standardize treatment, improve treatment effectiveness, and to minimize adverse effects as far as possible. Treatment protocols of psoriasis should be determined based on patient′s symptoms. Patients with mild psoriasis can be mainly treated with externally applied agents, those with moderate to severe psoriasis can be treated with systemic medications, and targeted biological agents can be appropriately chosen for those resistant to traditional systemic treatment. The main aim of psoriasis treatment is to control symptoms and improve the quality of life. With continuing development of novel drugs and regimens for psoriasis, we update guidelines to timely introduce new international and national achievements to domestic physicians, so as to keep pace with global progress in this field. Compared with the previous two editions of guidelines for diagnosis and treatment of psoriasis in China, some contents are supplemented and revised in this edition, which will further facilitate standardization of diagnosis and treatment of psoriasis in China, increase the efficiency of diagnosis and treatment, and improve the quality of life of patients.

【Abstract】 Vitiligo is a common depigmented skin disease， which seriously affects the physical and mental health of patients. According to clinical experience of experts as well as research progress in vitiligo in the past 3 years, the Pigmentary Disorder Group, Combination of Traditional and Western Medicine Dermatology revised the statement "Diagnosis and treatment of vitiligo: an expert consensus statement （2018）" in terms of maintenance treatment of vitiligo and application of glucocorticoids, discussed the prospect for Janus kinase （JAK） inhibitors, and finally established this consensus.

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